{"id":16367,"date":"2025-12-26T10:09:02","date_gmt":"2025-12-26T10:09:02","guid":{"rendered":"https:\/\/nafosted.gov.vn\/?p=16367"},"modified":"2026-01-14T10:17:36","modified_gmt":"2026-01-14T10:17:36","slug":"nghiem-thu-nhiem-vu-khcn-theo-nghi-dinh-thu-ma-so-ndt-cn-21-24","status":"publish","type":"post","link":"https:\/\/nafosted.gov.vn\/nghiem-thu-nhiem-vu-khcn-theo-nghi-dinh-thu-ma-so-ndt-cn-21-24\/","title":{"rendered":"Nghi\u1ec7m thu nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0, m\u00e3 s\u1ed1 N\u0110T\/CN\/21\/24"},"content":{"rendered":"

Chi\u1ec1u ng\u00e0y 23\/12\/2025, B\u1ed9 Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 \u0111\u00e3 t\u1ed5 ch\u1ee9c phi\u00ean h\u1ecdp H\u1ed9i \u0111\u1ed3ng \u0111\u00e1nh gi\u00e1, nghi\u1ec7m thu k\u1ebft qu\u1ea3 th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0 \u201cNghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn gi\u1ed1ng l\u00faa v\u1ec1 vi ch\u1ea5t dinh d\u01b0\u1ee1ng b\u1eb1ng c\u00f4ng ngh\u1ec7 sinh h\u1ecdc\u201d – m\u00e3 s\u1ed1 N\u0110T\/CN\/21\/24.<\/strong><\/p>\n

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H\u1ed9i \u0111\u1ed3ng \u0111\u00e1nh gi\u00e1, nghi\u1ec7m thu nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0 \u201cNghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn gi\u1ed1ng l\u00faa v\u1ec1 vi ch\u1ea5t dinh d\u01b0\u1ee1ng b\u1eb1ng c\u00f4ng ngh\u1ec7 sinh h\u1ecdc\u201d – m\u00e3 s\u1ed1 N\u0110T\/CN\/21\/24<\/em><\/p>\n

H\u1ed9i \u0111\u1ed3ng nghi\u1ec7m thu nhi\u1ec7m v\u1ee5 g\u1ed3m c\u00f3\u00a009\u00a0th\u00e0nh vi\u00ean do\u00a0GS.TS. Nguy\u1ec5n Huy Ho\u00e0ng, Vi\u1ec7n Sinh h\u1ecdc, Vi\u1ec7n H\u00e0n l\u00e2m Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 Vi\u1ec7t Nam l\u00e0m Ch\u1ee7 t\u1ecbch H\u1ed9i\u00a0\u0111\u1ed3ng v\u00e0 GS.TS. Tr\u1ea7n \u0110\u00ecnh Long, H\u1ed9i Gi\u1ed1ng c\u00e2y tr\u1ed3ng Vi\u1ec7t Nam l\u00e0m Ph\u00f3 ch\u1ee7 t\u1ecbch H\u1ed9i \u0111\u1ed3ng.<\/p>\n

Nhi\u1ec7m v\u1ee5 \u201cNghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn gi\u1ed1ng l\u00faa v\u1ec1 vi ch\u1ea5t dinh d\u01b0\u1ee1ng b\u1eb1ng c\u00f4ng ngh\u1ec7 sinh h\u1ecdc\u201d \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n t\u1eeb ng\u00e0y 02 th\u00e1ng 07 n\u0103m 2021 tr\u00ean c\u01a1 s\u1edf Quy\u1ebft \u0111\u1ecbnh s\u1ed1 959\/Q\u0110- BKHCN ng\u00e0y 26\/04\/2021 c\u1ee7a B\u1ed9 tr\u01b0\u1edfng B\u1ed9 Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 ph\u00ea duy\u1ec7t t\u1ed5 ch\u1ee9c ch\u1ee7 tr\u00ec, c\u00e1 nh\u00e2n ch\u1ee7 nhi\u1ec7m, kinh ph\u00ed, th\u1eddi gian th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0. Theo \u0111\u00f3, nhi\u1ec7m v\u1ee5 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n d\u01b0\u1edbi s\u1ef1 ch\u1ee7 tr\u00ec c\u1ee7a Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc T\u1ef1 nhi\u00ean, \u0110\u1ea1i h\u1ecdc Qu\u1ed1c gia H\u00e0 N\u1ed9i, do TS. L\u00ea Qu\u1ef3nh Mai l\u00e0 ch\u1ee7 nhi\u1ec7m nhi\u1ec7m v\u1ee5 v\u1edbi m\u1ee5c ti\u00eau ch\u00ednh l\u00e0: C\u1ea3i ti\u1ebfn \u0111\u01b0\u1ee3c h\u00e0m l\u01b0\u1ee3ng vi ch\u1ea5t dinh d\u01b0\u1ee1ng (t\u0103ng h\u00e0m l\u01b0\u1ee3ng Fe\/Zn) v\u00e0 gi\u1ea3m h\u00e0m l\u01b0\u1ee3ng Cd b\u1eb1ng c\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda h\u1ec7 gen, nh\u1eb1m n\u00e2ng cao gi\u00e1 tr\u1ecb c\u1ee7a l\u00faa g\u1ea1o. Nhi\u1ec7m v\u1ee5 \u0111\u00e3 \u00e1p d\u1ee5ng c\u00f4ng ngh\u1ec7 CRISPR\/Cas9 v\u1edbi c\u00e1c \u01b0u \u0111i\u1ec3m ch\u00ednh l\u00e0 can thi\u1ec7p ch\u00ednh x\u00e1c t\u1edbi v\u1ecb tr\u00ed mong mu\u1ed1n tr\u00ean h\u1ec7 gene, \u0111\u1ed9 \u0111\u1eb7c hi\u1ec7u cao v\u00e0 h\u1ea1n ch\u1ebf l\u01b0\u1ee3ng DNA ngo\u1ea1i lai t\u1ed3n t\u1ea1i trong c\u00e1c d\u00f2ng ch\u1ec9nh s\u1eeda.<\/p>\n

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Th\u00e0nh vi\u00ean H\u1ed9i \u0111\u1ed3ng nh\u1eadn x\u00e9t nhi\u1ec7m v\u1ee5<\/em><\/p>\n

Sau 48 th\u00e1ng tri\u1ec3n khai, nhi\u1ec7m v\u1ee5 \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng k\u1ebft qu\u1ea3 \u0111\u00e1ng ghi nh\u1eadn:<\/p>\n

– Thi\u1ebft k\u1ebf \u0111\u01b0\u1ee3c 04 c\u1ea5u tr\u00fac CRISPR\/Cas9 mang y\u1ebfu t\u1ed1 ch\u1ec9nh s\u1eeda h\u1ec7 gen li\u00ean quan \u0111\u1ebfn t\u0103ng kh\u1ea3 n\u0103ng t\u00edch l\u0169y vi ch\u1ea5t dinh d\u01b0\u1ee1ng (Fe\/Zn) v\u00e0 gi\u1ea3m h\u1ea5p thu c\u00e1c kim lo\u1ea1i n\u1eb7ng (Cd) ph\u00f9 h\u1ee3p \u0111\u1ec3 ch\u1ec9nh s\u1eeda h\u1ec7 gen v\u1edbi gi\u1ed1ng l\u00faa m\u1ee5c ti\u00eau \u0111\u01b0\u1ee3c ch\u1ecdn l\u00e0 TBR225. Trong \u0111\u00f3 c, c\u00e1c c\u1ea5u tr\u00fac ch\u1ec9nh s\u1eeda v\u1edbi c\u00e1c gen \u0111\u00edch OsNRAMP2, OsNRAMP5 \u0111\u00e3 \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf v\u1edbi m\u1ee5c ti\u00eau g\u00e2y \u0111\u1ed9t bi\u1ebfn gen; C\u1ea5u tr\u00fac s\u1eed d\u1ee5ng h\u1ec7 th\u1ed1ng s\u1eeda ch\u1eefa t\u01b0\u01a1ng \u0111\u1ed3ng c\u1ee7a CRISPR \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng bi\u1ec3u hi\u1ec7n gen OsNRAMP7 v\u00e0 C\u1ea5u tr\u00fac s\u1eed d\u1ee5ng ho\u1ea1t t\u00ednh b\u00e1m m\u00e0 kh\u00f4ng s\u1eed d\u1ee5ng ho\u1ea1t t\u00ednh c\u1eaft c\u1ee7a Cas9 v\u1edbi gen \u0111\u00edch OsYSL2<\/p>\n

– Thi\u1ebft l\u1eadp \u0111\u01b0\u1ee3c Quy tr\u00ecnh ch\u1ec9nh s\u1eeda h\u1ec7 gen li\u00ean quan \u0111\u1ebfn vi ch\u1ea5t dinh d\u01b0\u1ee1ng \u1edf l\u00faa tr\u00ean c\u01a1 s\u1edf nghi\u00ean c\u1ee9u quy tr\u00ecnh ch\u1ec9nh s\u1eeda gen OsNRAMP5 \u1edf gi\u1ed1ng l\u00faa TBR225. Quy tr\u00ecnh \u0111\u1ea1t hi\u1ec7u su\u1ea5t t\u00e1i sinh 16,51% (t\u00ednh tr\u00ean t\u1ed5ng s\u1ed1 m\u00f4 s\u1eb9o), hi\u1ec7u su\u1ea5t chuy\u1ec3n gen 38,46% (t\u00ednh tr\u00ean t\u1ed5ng s\u1ed1 c\u00e2y t\u00e1i sinh) v\u00e0 hi\u1ec7u su\u1ea5t ch\u1ec9nh s\u1eeda gen \u0111\u00edch 30% (t\u00ednh tr\u00ean t\u1ed5ng s\u1ed1 c\u00e2y mang gen chuy\u1ec3n).<\/p>\n

– Thu \u0111\u01b0\u1ee3c 03 d\u00f2ng l\u00faa \u0111\u1ed9t bi\u1ebfn gen OsNRAMP5 c\u00f3 h\u00e0m l\u01b0\u1ee3ng Cd gi\u1ea3m v\u00e0 01 d\u00f2ng l\u00faa t\u0103ng c\u01b0\u1eddng bi\u1ec3u hi\u1ec7n gen OsNRAMP7 c\u00f3 h\u00e0m l\u01b0\u1ee3ng Fe, Zn t\u0103ng v\u00e0 h\u00e0m l\u01b0\u1ee3ng Cd gi\u1ea3m.<\/p>\n

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C\u00e1c m\u1eabu h\u1ea1t c\u1ee7a c\u00e1c d\u00f2ng l\u00faa ch\u1ec9nh s\u1eeda gen – s\u1ea3n ph\u1ea9m c\u1ee7a \u0111\u1ec1 t\u00e0i<\/em><\/p>\n

Trong qu\u00e1 tr\u00ecnh th\u1ef1c hi\u1ec7n, Nhi\u1ec7m v\u1ee5 \u0111\u00e3 c\u00f4ng b\u1ed1 04 b\u00e0i b\u00e1o tr\u00ean t\u1ea1p ch\u00ed qu\u1ed1c t\u1ebf thu\u1ed9c danh m\u1ee5c Scopus, 03b\u00e0i b\u00e1o tr\u00ean t\u1ea1p ch\u00ed khoa h\u1ecdc trong n\u01b0\u1edbc v\u00e0 01 b\u00e0i to\u00e0n v\u0103n tr\u00ean K\u1ef7 y\u1ebfu h\u1ed9i ngh\u1ecb C\u00f4ng ngh\u1ec7 sinh h\u1ecdc to\u00e0n qu\u1ed1c; \u0111\u1ed3ng th\u1eddi \u0111\u00e0o t\u1ea1o th\u00e0nh c\u00f4ng 03 th\u1ea1c s\u0129. V\u1edbi vai tr\u00f2 l\u00e0 m\u1ed9t nhi\u1ec7m v\u1ee5 theo ngh\u1ecb \u0111\u1ecbnh th\u01b0, nhi\u1ec7m v\u1ee5 \u0111\u00e3 th\u00fac \u0111\u1ea9y t\u0103ng c\u01b0\u1eddng h\u1ee3p t\u00e1c qu\u1ed1c t\u1ebf, \u0111\u1eb7c bi\u1ec7t v\u1edbi \u0111\u1ed1i t\u00e1c l\u00e0 Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc N\u00f4ng nghi\u1ec7p Nam Kinh, Giang T\u00f4, Trung Qu\u1ed1c. Ph\u00eda \u0111\u1ed1i t\u00e1c \u0111\u00e3 h\u1ed7 tr\u1ee3 v\u1eadt li\u1ec7u v\u00e0 ph\u1ed5 bi\u1ebfn k\u1ef9 thu\u1eadt \u0111\u1ec3 nh\u00f3m nghi\u00ean c\u1ee9u b\u01b0\u1edbc \u0111\u1ea7u tri\u1ec3n khai ch\u1ec9nh s\u1eeda \u0111a gen, m\u1ed9t h\u01b0\u1edbng nghi\u00ean c\u1ee9u ti\u1ec1m n\u0103ng trong l\u0129nh v\u1ef1c ph\u00e1t tri\u1ec3n ch\u1ecdn t\u1ea1o gi\u1ed1ng c\u00e2y tr\u1ed3ng.<\/p>\n

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Ch\u1ee7 nhi\u1ec7m nhi\u1ec7m v\u1ee5 ph\u00eda Vi\u1ec7t Nam – TS. L\u00ea Qu\u1ef3nh Mai v\u00e0 PGS.TS. Chen Xi, Vice-Dean of College of Life Science, \u0110\u1ea1i h\u1ecdc N\u00f4ng nghi\u1ec7p Nam Kinh.<\/em><\/p>\n

C\u00e1c th\u00e0nh vi\u00ean H\u1ed9i \u0111\u1ed3ng nghi\u1ec7m thu \u0111\u00e1nh gi\u00e1 cao c\u00e1c k\u1ebft qu\u1ea3 m\u00e0 nh\u00f3m th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5 \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c, ghi nh\u1eadn c\u00e1c s\u1ea3n ph\u1ea9m \u0111\u00e3 \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 ch\u1ee7ng lo\u1ea1i, s\u1ed1 l\u01b0\u1ee3ng, ch\u1ea5t l\u01b0\u1ee3ng so v\u1edbi \u0111\u1eb7t h\u00e0ng, s\u1ea3n ph\u1ea9m c\u00f4ng b\u1ed1 khoa h\u1ecdc v\u00e0 \u0111\u00e0o t\u1ea1o \u0111\u1ec1u v\u01b0\u1ee3t y\u00eau c\u1ea7u. Tr\u00ean c\u01a1 s\u1edf \u0111\u00f3, to\u00e0n th\u1ec3 9\/9 th\u00e0nh vi\u00ean h\u1ed9i \u0111\u1ed3ng \u0111\u1ec1u nh\u1ea5t tr\u00ed nghi\u1ec7m thu \u0111\u1ec1 t\u00e0i v\u1edbi m\u1ee9c “\u0110\u1ea1t”.<\/strong>\u00a0C\u00e1c th\u00e0nh vi\u00ean h\u1ed9i \u0111\u1ed3ng c\u0169ng \u0111\u00e3 g\u00f3p c\u00e1c \u00fd ki\u1ebfn x\u00e1c \u0111\u00e1ng \u0111\u1ec3 nh\u00f3m nghi\u00ean c\u1ee9u ch\u1ec9nh s\u1eeda, ho\u00e0n thi\u1ec7n h\u1ed3 s\u01a1 tr\u00ecnh B\u1ed9 Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 ra quy\u1ebft \u0111\u1ecbnh c\u00f4ng nh\u1eadn k\u1ebft qu\u1ea3 c\u1ee7a nhi\u1ec7m v\u1ee5.\/.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Chi\u1ec1u ng\u00e0y 23\/12\/2025, B\u1ed9 Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 \u0111\u00e3 t\u1ed5 ch\u1ee9c phi\u00ean h\u1ecdp H\u1ed9i \u0111\u1ed3ng \u0111\u00e1nh gi\u00e1, nghi\u1ec7m thu k\u1ebft qu\u1ea3 th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0 \u201cNghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn gi\u1ed1ng l\u00faa v\u1ec1 vi ch\u1ea5t dinh d\u01b0\u1ee1ng b\u1eb1ng c\u00f4ng ngh\u1ec7 sinh h\u1ecdc\u201d – m\u00e3 s\u1ed1 N\u0110T\/CN\/21\/24. H\u1ed9i \u0111\u1ed3ng \u0111\u00e1nh gi\u00e1, nghi\u1ec7m thu nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0 \u201cNghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn gi\u1ed1ng l\u00faa v\u1ec1 vi ch\u1ea5t dinh d\u01b0\u1ee1ng b\u1eb1ng c\u00f4ng ngh\u1ec7 sinh h\u1ecdc\u201d – m\u00e3 s\u1ed1 N\u0110T\/CN\/21\/24 H\u1ed9i \u0111\u1ed3ng nghi\u1ec7m thu nhi\u1ec7m v\u1ee5 g\u1ed3m c\u00f3\u00a009\u00a0th\u00e0nh vi\u00ean do\u00a0GS.TS. Nguy\u1ec5n Huy Ho\u00e0ng, Vi\u1ec7n Sinh h\u1ecdc, Vi\u1ec7n H\u00e0n l\u00e2m Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 Vi\u1ec7t Nam l\u00e0m Ch\u1ee7 t\u1ecbch H\u1ed9i\u00a0\u0111\u1ed3ng v\u00e0 GS.TS. Tr\u1ea7n \u0110\u00ecnh Long, H\u1ed9i Gi\u1ed1ng c\u00e2y tr\u1ed3ng Vi\u1ec7t Nam l\u00e0m Ph\u00f3 ch\u1ee7 t\u1ecbch H\u1ed9i \u0111\u1ed3ng. Nhi\u1ec7m v\u1ee5 \u201cNghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn gi\u1ed1ng l\u00faa v\u1ec1 vi ch\u1ea5t dinh d\u01b0\u1ee1ng b\u1eb1ng c\u00f4ng ngh\u1ec7 sinh h\u1ecdc\u201d \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n t\u1eeb ng\u00e0y 02 th\u00e1ng 07 n\u0103m 2021 tr\u00ean c\u01a1 s\u1edf Quy\u1ebft \u0111\u1ecbnh s\u1ed1 959\/Q\u0110- BKHCN ng\u00e0y 26\/04\/2021 c\u1ee7a B\u1ed9 tr\u01b0\u1edfng B\u1ed9 Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 ph\u00ea duy\u1ec7t t\u1ed5 ch\u1ee9c ch\u1ee7 tr\u00ec, c\u00e1 nh\u00e2n ch\u1ee7 nhi\u1ec7m, kinh ph\u00ed, th\u1eddi gian th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0. Theo \u0111\u00f3, nhi\u1ec7m v\u1ee5 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n d\u01b0\u1edbi s\u1ef1 ch\u1ee7 tr\u00ec c\u1ee7a Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc T\u1ef1 nhi\u00ean, \u0110\u1ea1i h\u1ecdc Qu\u1ed1c gia H\u00e0 N\u1ed9i, do TS. L\u00ea Qu\u1ef3nh Mai l\u00e0 ch\u1ee7 nhi\u1ec7m nhi\u1ec7m v\u1ee5 v\u1edbi m\u1ee5c ti\u00eau ch\u00ednh l\u00e0: C\u1ea3i ti\u1ebfn \u0111\u01b0\u1ee3c h\u00e0m l\u01b0\u1ee3ng vi ch\u1ea5t dinh d\u01b0\u1ee1ng (t\u0103ng h\u00e0m l\u01b0\u1ee3ng Fe\/Zn) v\u00e0 gi\u1ea3m h\u00e0m l\u01b0\u1ee3ng Cd b\u1eb1ng c\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda h\u1ec7 gen, nh\u1eb1m n\u00e2ng cao gi\u00e1 tr\u1ecb c\u1ee7a l\u00faa g\u1ea1o. Nhi\u1ec7m v\u1ee5 \u0111\u00e3 \u00e1p d\u1ee5ng c\u00f4ng ngh\u1ec7 CRISPR\/Cas9 v\u1edbi c\u00e1c \u01b0u \u0111i\u1ec3m ch\u00ednh l\u00e0 can thi\u1ec7p ch\u00ednh x\u00e1c t\u1edbi v\u1ecb tr\u00ed mong mu\u1ed1n tr\u00ean h\u1ec7 gene, \u0111\u1ed9 \u0111\u1eb7c hi\u1ec7u cao v\u00e0 h\u1ea1n ch\u1ebf l\u01b0\u1ee3ng DNA ngo\u1ea1i lai t\u1ed3n t\u1ea1i trong c\u00e1c d\u00f2ng ch\u1ec9nh s\u1eeda. Th\u00e0nh vi\u00ean H\u1ed9i \u0111\u1ed3ng nh\u1eadn x\u00e9t nhi\u1ec7m v\u1ee5 Sau 48 th\u00e1ng tri\u1ec3n khai, nhi\u1ec7m v\u1ee5 \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng k\u1ebft qu\u1ea3 \u0111\u00e1ng ghi nh\u1eadn: – Thi\u1ebft k\u1ebf \u0111\u01b0\u1ee3c 04 c\u1ea5u tr\u00fac CRISPR\/Cas9 mang y\u1ebfu t\u1ed1 ch\u1ec9nh s\u1eeda h\u1ec7 gen li\u00ean quan \u0111\u1ebfn t\u0103ng kh\u1ea3 n\u0103ng t\u00edch l\u0169y vi ch\u1ea5t dinh d\u01b0\u1ee1ng (Fe\/Zn) v\u00e0 gi\u1ea3m h\u1ea5p thu c\u00e1c kim lo\u1ea1i n\u1eb7ng (Cd) ph\u00f9 h\u1ee3p \u0111\u1ec3 ch\u1ec9nh s\u1eeda h\u1ec7 gen v\u1edbi gi\u1ed1ng l\u00faa m\u1ee5c ti\u00eau \u0111\u01b0\u1ee3c ch\u1ecdn l\u00e0 TBR225. Trong \u0111\u00f3 c, c\u00e1c c\u1ea5u tr\u00fac ch\u1ec9nh s\u1eeda v\u1edbi c\u00e1c gen \u0111\u00edch OsNRAMP2, OsNRAMP5 \u0111\u00e3 \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf v\u1edbi m\u1ee5c ti\u00eau g\u00e2y \u0111\u1ed9t bi\u1ebfn gen; C\u1ea5u tr\u00fac s\u1eed d\u1ee5ng h\u1ec7 th\u1ed1ng s\u1eeda ch\u1eefa t\u01b0\u01a1ng \u0111\u1ed3ng c\u1ee7a CRISPR \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng bi\u1ec3u hi\u1ec7n gen OsNRAMP7 v\u00e0 C\u1ea5u tr\u00fac s\u1eed d\u1ee5ng ho\u1ea1t t\u00ednh b\u00e1m m\u00e0 kh\u00f4ng s\u1eed d\u1ee5ng ho\u1ea1t t\u00ednh c\u1eaft c\u1ee7a Cas9 v\u1edbi gen \u0111\u00edch OsYSL2 – Thi\u1ebft l\u1eadp \u0111\u01b0\u1ee3c Quy tr\u00ecnh ch\u1ec9nh s\u1eeda h\u1ec7 gen li\u00ean quan \u0111\u1ebfn vi ch\u1ea5t dinh d\u01b0\u1ee1ng \u1edf l\u00faa tr\u00ean c\u01a1 s\u1edf nghi\u00ean c\u1ee9u quy tr\u00ecnh ch\u1ec9nh s\u1eeda gen OsNRAMP5 \u1edf gi\u1ed1ng l\u00faa TBR225. Quy tr\u00ecnh \u0111\u1ea1t hi\u1ec7u su\u1ea5t t\u00e1i sinh 16,51% (t\u00ednh tr\u00ean t\u1ed5ng s\u1ed1 m\u00f4 s\u1eb9o), hi\u1ec7u su\u1ea5t chuy\u1ec3n gen 38,46% (t\u00ednh tr\u00ean t\u1ed5ng s\u1ed1 c\u00e2y t\u00e1i sinh) v\u00e0 hi\u1ec7u su\u1ea5t ch\u1ec9nh s\u1eeda gen \u0111\u00edch 30% (t\u00ednh tr\u00ean t\u1ed5ng s\u1ed1 c\u00e2y mang gen chuy\u1ec3n). – Thu \u0111\u01b0\u1ee3c 03 d\u00f2ng l\u00faa \u0111\u1ed9t bi\u1ebfn gen OsNRAMP5 c\u00f3 h\u00e0m l\u01b0\u1ee3ng Cd gi\u1ea3m v\u00e0 01 d\u00f2ng l\u00faa t\u0103ng c\u01b0\u1eddng bi\u1ec3u hi\u1ec7n gen OsNRAMP7 c\u00f3 h\u00e0m l\u01b0\u1ee3ng Fe, Zn t\u0103ng v\u00e0 h\u00e0m l\u01b0\u1ee3ng Cd gi\u1ea3m. C\u00e1c m\u1eabu h\u1ea1t c\u1ee7a c\u00e1c d\u00f2ng l\u00faa ch\u1ec9nh s\u1eeda gen – s\u1ea3n ph\u1ea9m c\u1ee7a \u0111\u1ec1 t\u00e0i Trong qu\u00e1 tr\u00ecnh th\u1ef1c hi\u1ec7n, Nhi\u1ec7m v\u1ee5 \u0111\u00e3 c\u00f4ng b\u1ed1 04 b\u00e0i b\u00e1o tr\u00ean t\u1ea1p ch\u00ed qu\u1ed1c t\u1ebf thu\u1ed9c danh m\u1ee5c Scopus, 03b\u00e0i b\u00e1o tr\u00ean t\u1ea1p ch\u00ed khoa h\u1ecdc trong n\u01b0\u1edbc v\u00e0 01 b\u00e0i to\u00e0n v\u0103n tr\u00ean K\u1ef7 y\u1ebfu h\u1ed9i ngh\u1ecb C\u00f4ng ngh\u1ec7 sinh h\u1ecdc to\u00e0n qu\u1ed1c; \u0111\u1ed3ng th\u1eddi \u0111\u00e0o t\u1ea1o th\u00e0nh c\u00f4ng 03 th\u1ea1c s\u0129. V\u1edbi vai tr\u00f2 l\u00e0 m\u1ed9t nhi\u1ec7m v\u1ee5 theo ngh\u1ecb \u0111\u1ecbnh th\u01b0, nhi\u1ec7m v\u1ee5 \u0111\u00e3 th\u00fac \u0111\u1ea9y t\u0103ng c\u01b0\u1eddng h\u1ee3p t\u00e1c qu\u1ed1c t\u1ebf, \u0111\u1eb7c bi\u1ec7t v\u1edbi \u0111\u1ed1i t\u00e1c l\u00e0 Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc N\u00f4ng nghi\u1ec7p Nam Kinh, Giang T\u00f4, Trung Qu\u1ed1c. Ph\u00eda \u0111\u1ed1i t\u00e1c \u0111\u00e3 h\u1ed7 tr\u1ee3 v\u1eadt li\u1ec7u v\u00e0 ph\u1ed5 bi\u1ebfn k\u1ef9 thu\u1eadt \u0111\u1ec3 nh\u00f3m nghi\u00ean c\u1ee9u b\u01b0\u1edbc \u0111\u1ea7u tri\u1ec3n khai ch\u1ec9nh s\u1eeda \u0111a gen, m\u1ed9t h\u01b0\u1edbng nghi\u00ean c\u1ee9u ti\u1ec1m n\u0103ng trong l\u0129nh v\u1ef1c ph\u00e1t tri\u1ec3n ch\u1ecdn t\u1ea1o gi\u1ed1ng c\u00e2y tr\u1ed3ng. Ch\u1ee7 nhi\u1ec7m nhi\u1ec7m v\u1ee5 ph\u00eda Vi\u1ec7t Nam – TS. L\u00ea Qu\u1ef3nh Mai v\u00e0 PGS.TS. Chen Xi, Vice-Dean of College of Life Science, \u0110\u1ea1i h\u1ecdc N\u00f4ng nghi\u1ec7p Nam Kinh. C\u00e1c th\u00e0nh vi\u00ean H\u1ed9i \u0111\u1ed3ng nghi\u1ec7m thu \u0111\u00e1nh gi\u00e1 cao c\u00e1c k\u1ebft qu\u1ea3 m\u00e0 nh\u00f3m th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5 \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c, ghi nh\u1eadn c\u00e1c s\u1ea3n ph\u1ea9m \u0111\u00e3 \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 ch\u1ee7ng lo\u1ea1i, s\u1ed1 l\u01b0\u1ee3ng, ch\u1ea5t l\u01b0\u1ee3ng so v\u1edbi \u0111\u1eb7t h\u00e0ng, s\u1ea3n ph\u1ea9m c\u00f4ng b\u1ed1 khoa h\u1ecdc v\u00e0 \u0111\u00e0o t\u1ea1o \u0111\u1ec1u v\u01b0\u1ee3t y\u00eau c\u1ea7u. Tr\u00ean c\u01a1 s\u1edf \u0111\u00f3, to\u00e0n th\u1ec3 9\/9 th\u00e0nh vi\u00ean h\u1ed9i \u0111\u1ed3ng \u0111\u1ec1u nh\u1ea5t tr\u00ed nghi\u1ec7m thu \u0111\u1ec1 t\u00e0i v\u1edbi m\u1ee9c “\u0110\u1ea1t”.\u00a0C\u00e1c th\u00e0nh vi\u00ean h\u1ed9i \u0111\u1ed3ng c\u0169ng \u0111\u00e3 g\u00f3p c\u00e1c \u00fd ki\u1ebfn x\u00e1c \u0111\u00e1ng \u0111\u1ec3 nh\u00f3m nghi\u00ean c\u1ee9u ch\u1ec9nh s\u1eeda, ho\u00e0n thi\u1ec7n h\u1ed3 s\u01a1 tr\u00ecnh B\u1ed9 Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 ra quy\u1ebft \u0111\u1ecbnh c\u00f4ng nh\u1eadn k\u1ebft qu\u1ea3 c\u1ee7a nhi\u1ec7m v\u1ee5.\/. 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ng\u00e0y 23\/12\/2025, B\u1ed9 Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 \u0111\u00e3 t\u1ed5 ch\u1ee9c phi\u00ean h\u1ecdp H\u1ed9i \u0111\u1ed3ng \u0111\u00e1nh gi\u00e1, nghi\u1ec7m thu k\u1ebft qu\u1ea3 th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0 \u201cNghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn gi\u1ed1ng l\u00faa v\u1ec1 vi ch\u1ea5t dinh d\u01b0\u1ee1ng b\u1eb1ng c\u00f4ng ngh\u1ec7 sinh h\u1ecdc\u201d – m\u00e3 s\u1ed1 N\u0110T\/CN\/21\/24. H\u1ed9i \u0111\u1ed3ng \u0111\u00e1nh gi\u00e1, nghi\u1ec7m thu nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0 \u201cNghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn gi\u1ed1ng l\u00faa v\u1ec1 vi ch\u1ea5t dinh d\u01b0\u1ee1ng b\u1eb1ng c\u00f4ng ngh\u1ec7 sinh h\u1ecdc\u201d – m\u00e3 s\u1ed1 N\u0110T\/CN\/21\/24 H\u1ed9i \u0111\u1ed3ng nghi\u1ec7m thu nhi\u1ec7m v\u1ee5 g\u1ed3m c\u00f3\u00a009\u00a0th\u00e0nh vi\u00ean do\u00a0GS.TS. Nguy\u1ec5n Huy Ho\u00e0ng, Vi\u1ec7n Sinh h\u1ecdc, Vi\u1ec7n H\u00e0n l\u00e2m Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 Vi\u1ec7t Nam l\u00e0m Ch\u1ee7 t\u1ecbch H\u1ed9i\u00a0\u0111\u1ed3ng v\u00e0 GS.TS. Tr\u1ea7n \u0110\u00ecnh Long, H\u1ed9i Gi\u1ed1ng c\u00e2y tr\u1ed3ng Vi\u1ec7t Nam l\u00e0m Ph\u00f3 ch\u1ee7 t\u1ecbch H\u1ed9i \u0111\u1ed3ng. Nhi\u1ec7m v\u1ee5 \u201cNghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn gi\u1ed1ng l\u00faa v\u1ec1 vi ch\u1ea5t dinh d\u01b0\u1ee1ng b\u1eb1ng c\u00f4ng ngh\u1ec7 sinh h\u1ecdc\u201d \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n t\u1eeb ng\u00e0y 02 th\u00e1ng 07 n\u0103m 2021 tr\u00ean c\u01a1 s\u1edf Quy\u1ebft \u0111\u1ecbnh s\u1ed1 959\/Q\u0110- BKHCN ng\u00e0y 26\/04\/2021 c\u1ee7a B\u1ed9 tr\u01b0\u1edfng B\u1ed9 Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 ph\u00ea duy\u1ec7t t\u1ed5 ch\u1ee9c ch\u1ee7 tr\u00ec, c\u00e1 nh\u00e2n ch\u1ee7 nhi\u1ec7m, kinh ph\u00ed, th\u1eddi gian th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0. Theo \u0111\u00f3, nhi\u1ec7m v\u1ee5 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n d\u01b0\u1edbi s\u1ef1 ch\u1ee7 tr\u00ec c\u1ee7a Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc T\u1ef1 nhi\u00ean, \u0110\u1ea1i h\u1ecdc Qu\u1ed1c gia H\u00e0 N\u1ed9i, do TS. L\u00ea Qu\u1ef3nh Mai l\u00e0 ch\u1ee7 nhi\u1ec7m nhi\u1ec7m v\u1ee5 v\u1edbi m\u1ee5c ti\u00eau ch\u00ednh l\u00e0: C\u1ea3i ti\u1ebfn \u0111\u01b0\u1ee3c h\u00e0m l\u01b0\u1ee3ng vi ch\u1ea5t dinh d\u01b0\u1ee1ng (t\u0103ng h\u00e0m l\u01b0\u1ee3ng Fe\/Zn) v\u00e0 gi\u1ea3m h\u00e0m l\u01b0\u1ee3ng Cd b\u1eb1ng c\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda h\u1ec7 gen, nh\u1eb1m n\u00e2ng cao gi\u00e1 tr\u1ecb c\u1ee7a l\u00faa g\u1ea1o. Nhi\u1ec7m v\u1ee5 \u0111\u00e3 \u00e1p d\u1ee5ng c\u00f4ng ngh\u1ec7 CRISPR\/Cas9 v\u1edbi c\u00e1c \u01b0u \u0111i\u1ec3m ch\u00ednh l\u00e0 can thi\u1ec7p ch\u00ednh x\u00e1c t\u1edbi v\u1ecb tr\u00ed mong mu\u1ed1n tr\u00ean h\u1ec7 gene, \u0111\u1ed9 \u0111\u1eb7c hi\u1ec7u cao v\u00e0 h\u1ea1n ch\u1ebf l\u01b0\u1ee3ng DNA ngo\u1ea1i lai t\u1ed3n t\u1ea1i trong c\u00e1c d\u00f2ng ch\u1ec9nh s\u1eeda. Th\u00e0nh vi\u00ean H\u1ed9i \u0111\u1ed3ng nh\u1eadn x\u00e9t nhi\u1ec7m v\u1ee5 Sau 48 th\u00e1ng tri\u1ec3n khai, nhi\u1ec7m v\u1ee5 \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng k\u1ebft qu\u1ea3 \u0111\u00e1ng ghi nh\u1eadn: – Thi\u1ebft k\u1ebf \u0111\u01b0\u1ee3c 04 c\u1ea5u tr\u00fac CRISPR\/Cas9 mang y\u1ebfu t\u1ed1 ch\u1ec9nh s\u1eeda h\u1ec7 gen li\u00ean quan \u0111\u1ebfn t\u0103ng kh\u1ea3 n\u0103ng t\u00edch l\u0169y vi ch\u1ea5t dinh d\u01b0\u1ee1ng (Fe\/Zn) v\u00e0 gi\u1ea3m h\u1ea5p thu c\u00e1c kim lo\u1ea1i n\u1eb7ng (Cd) ph\u00f9 h\u1ee3p \u0111\u1ec3 ch\u1ec9nh s\u1eeda h\u1ec7 gen v\u1edbi gi\u1ed1ng l\u00faa m\u1ee5c ti\u00eau \u0111\u01b0\u1ee3c ch\u1ecdn l\u00e0 TBR225. Trong \u0111\u00f3 c, c\u00e1c c\u1ea5u tr\u00fac ch\u1ec9nh s\u1eeda v\u1edbi c\u00e1c gen \u0111\u00edch OsNRAMP2, OsNRAMP5 \u0111\u00e3 \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf v\u1edbi m\u1ee5c ti\u00eau g\u00e2y \u0111\u1ed9t bi\u1ebfn gen; C\u1ea5u tr\u00fac s\u1eed d\u1ee5ng h\u1ec7 th\u1ed1ng s\u1eeda ch\u1eefa t\u01b0\u01a1ng \u0111\u1ed3ng c\u1ee7a CRISPR \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng bi\u1ec3u hi\u1ec7n gen OsNRAMP7 v\u00e0 C\u1ea5u tr\u00fac s\u1eed d\u1ee5ng ho\u1ea1t t\u00ednh b\u00e1m m\u00e0 kh\u00f4ng s\u1eed d\u1ee5ng ho\u1ea1t t\u00ednh c\u1eaft c\u1ee7a Cas9 v\u1edbi gen \u0111\u00edch OsYSL2 – Thi\u1ebft l\u1eadp \u0111\u01b0\u1ee3c Quy tr\u00ecnh ch\u1ec9nh s\u1eeda h\u1ec7 gen li\u00ean quan \u0111\u1ebfn vi ch\u1ea5t dinh d\u01b0\u1ee1ng \u1edf l\u00faa tr\u00ean c\u01a1 s\u1edf nghi\u00ean c\u1ee9u quy tr\u00ecnh ch\u1ec9nh s\u1eeda gen OsNRAMP5 \u1edf gi\u1ed1ng l\u00faa TBR225. Quy tr\u00ecnh \u0111\u1ea1t hi\u1ec7u su\u1ea5t t\u00e1i sinh 16,51% (t\u00ednh tr\u00ean t\u1ed5ng s\u1ed1 m\u00f4 s\u1eb9o), hi\u1ec7u su\u1ea5t chuy\u1ec3n gen 38,46% (t\u00ednh tr\u00ean t\u1ed5ng s\u1ed1 c\u00e2y t\u00e1i sinh) v\u00e0 hi\u1ec7u su\u1ea5t ch\u1ec9nh s\u1eeda gen \u0111\u00edch 30% (t\u00ednh tr\u00ean t\u1ed5ng s\u1ed1 c\u00e2y mang gen chuy\u1ec3n). – Thu \u0111\u01b0\u1ee3c 03 d\u00f2ng l\u00faa \u0111\u1ed9t bi\u1ebfn gen OsNRAMP5 c\u00f3 h\u00e0m l\u01b0\u1ee3ng Cd gi\u1ea3m v\u00e0 01 d\u00f2ng l\u00faa t\u0103ng c\u01b0\u1eddng bi\u1ec3u hi\u1ec7n gen OsNRAMP7 c\u00f3 h\u00e0m l\u01b0\u1ee3ng Fe, Zn t\u0103ng v\u00e0 h\u00e0m l\u01b0\u1ee3ng Cd gi\u1ea3m. C\u00e1c m\u1eabu h\u1ea1t c\u1ee7a c\u00e1c d\u00f2ng l\u00faa ch\u1ec9nh s\u1eeda gen – s\u1ea3n ph\u1ea9m c\u1ee7a \u0111\u1ec1 t\u00e0i Trong qu\u00e1 tr\u00ecnh th\u1ef1c hi\u1ec7n, Nhi\u1ec7m v\u1ee5 \u0111\u00e3 c\u00f4ng b\u1ed1 04 b\u00e0i b\u00e1o tr\u00ean t\u1ea1p ch\u00ed qu\u1ed1c t\u1ebf thu\u1ed9c danh m\u1ee5c Scopus, 03b\u00e0i b\u00e1o tr\u00ean t\u1ea1p ch\u00ed khoa h\u1ecdc trong n\u01b0\u1edbc v\u00e0 01 b\u00e0i to\u00e0n v\u0103n tr\u00ean K\u1ef7 y\u1ebfu h\u1ed9i ngh\u1ecb C\u00f4ng ngh\u1ec7 sinh h\u1ecdc to\u00e0n qu\u1ed1c; \u0111\u1ed3ng th\u1eddi \u0111\u00e0o t\u1ea1o th\u00e0nh c\u00f4ng 03 th\u1ea1c s\u0129. V\u1edbi vai tr\u00f2 l\u00e0 m\u1ed9t nhi\u1ec7m v\u1ee5 theo ngh\u1ecb \u0111\u1ecbnh th\u01b0, nhi\u1ec7m v\u1ee5 \u0111\u00e3 th\u00fac \u0111\u1ea9y t\u0103ng c\u01b0\u1eddng h\u1ee3p t\u00e1c qu\u1ed1c t\u1ebf, \u0111\u1eb7c bi\u1ec7t v\u1edbi \u0111\u1ed1i t\u00e1c l\u00e0 Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc N\u00f4ng nghi\u1ec7p Nam Kinh, Giang T\u00f4, Trung Qu\u1ed1c. Ph\u00eda \u0111\u1ed1i t\u00e1c \u0111\u00e3 h\u1ed7 tr\u1ee3 v\u1eadt li\u1ec7u v\u00e0 ph\u1ed5 bi\u1ebfn k\u1ef9 thu\u1eadt \u0111\u1ec3 nh\u00f3m nghi\u00ean c\u1ee9u b\u01b0\u1edbc \u0111\u1ea7u tri\u1ec3n khai ch\u1ec9nh s\u1eeda \u0111a gen, m\u1ed9t h\u01b0\u1edbng nghi\u00ean c\u1ee9u ti\u1ec1m n\u0103ng trong l\u0129nh v\u1ef1c ph\u00e1t tri\u1ec3n ch\u1ecdn t\u1ea1o gi\u1ed1ng c\u00e2y tr\u1ed3ng. Ch\u1ee7 nhi\u1ec7m nhi\u1ec7m v\u1ee5 ph\u00eda Vi\u1ec7t Nam – TS. L\u00ea Qu\u1ef3nh Mai v\u00e0 PGS.TS. Chen Xi, Vice-Dean of College of Life Science, \u0110\u1ea1i h\u1ecdc N\u00f4ng nghi\u1ec7p Nam Kinh. C\u00e1c th\u00e0nh vi\u00ean H\u1ed9i \u0111\u1ed3ng nghi\u1ec7m thu \u0111\u00e1nh gi\u00e1 cao c\u00e1c k\u1ebft qu\u1ea3 m\u00e0 nh\u00f3m th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5 \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c, ghi nh\u1eadn c\u00e1c s\u1ea3n ph\u1ea9m \u0111\u00e3 \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 ch\u1ee7ng lo\u1ea1i, s\u1ed1 l\u01b0\u1ee3ng, ch\u1ea5t l\u01b0\u1ee3ng so v\u1edbi \u0111\u1eb7t h\u00e0ng, s\u1ea3n ph\u1ea9m c\u00f4ng b\u1ed1 khoa h\u1ecdc v\u00e0 \u0111\u00e0o t\u1ea1o \u0111\u1ec1u v\u01b0\u1ee3t y\u00eau c\u1ea7u. Tr\u00ean c\u01a1 s\u1edf \u0111\u00f3, to\u00e0n th\u1ec3 9\/9 th\u00e0nh vi\u00ean h\u1ed9i \u0111\u1ed3ng \u0111\u1ec1u nh\u1ea5t tr\u00ed nghi\u1ec7m thu \u0111\u1ec1 t\u00e0i v\u1edbi m\u1ee9c “\u0110\u1ea1t”.\u00a0C\u00e1c th\u00e0nh vi\u00ean h\u1ed9i \u0111\u1ed3ng c\u0169ng \u0111\u00e3 g\u00f3p c\u00e1c \u00fd ki\u1ebfn x\u00e1c \u0111\u00e1ng \u0111\u1ec3 nh\u00f3m nghi\u00ean c\u1ee9u ch\u1ec9nh s\u1eeda, ho\u00e0n thi\u1ec7n h\u1ed3 s\u01a1 tr\u00ecnh B\u1ed9 Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 ra quy\u1ebft \u0111\u1ecbnh c\u00f4ng nh\u1eadn k\u1ebft qu\u1ea3 c\u1ee7a nhi\u1ec7m v\u1ee5.\/.  ","magazineBlocksPostCategories":["Th\u00f4ng tin k\u1ebft qu\u1ea3 th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5","Tin t\u1ee9c"],"magazineBlocksPostViewCount":1397,"magazineBlocksPostReadTime":8,"magazine_blocks_featured_image_url":{"full":["https:\/\/nafosted.gov.vn\/wp-content\/uploads\/2026\/01\/01-1.jpg",1267,950,false],"medium":["https:\/\/nafosted.gov.vn\/wp-content\/uploads\/2026\/01\/01-1-507x380.jpg",507,380,true],"thumbnail":["https:\/\/nafosted.gov.vn\/wp-content\/uploads\/2026\/01\/01-1-278x190.jpg",278,190,true]},"magazine_blocks_author":{"display_name":"admin","author_link":"https:\/\/nafosted.gov.vn\/author\/admin\/"},"magazine_blocks_comment":2,"magazine_blocks_author_image":"https:\/\/secure.gravatar.com\/avatar\/01be2b7eaa21fe4e25b709d19349c0fb?s=96&d=mm&r=g","magazine_blocks_category":"Th\u00f4ng tin k\u1ebft qu\u1ea3 th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5<\/a> Tin t\u1ee9c<\/a>","yoast_head":"\r\nNghi\u1ec7m thu nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0, m\u00e3 s\u1ed1 N\u0110T\/CN\/21\/24 - Qu\u1ef9 Ph\u00e1t tri\u1ec3n khoa h\u1ecdc v\u00e0 c\u00f4ng ngh\u1ec7 Qu\u1ed1c gia<\/title>\r\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\r\n<link rel=\"canonical\" href=\"https:\/\/nafosted.gov.vn\/nghiem-thu-nhiem-vu-khcn-theo-nghi-dinh-thu-ma-so-ndt-cn-21-24\/\" \/>\r\n<meta property=\"og:locale\" content=\"vi_VN\" \/>\r\n<meta property=\"og:type\" content=\"article\" \/>\r\n<meta property=\"og:title\" content=\"Nghi\u1ec7m thu nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0, m\u00e3 s\u1ed1 N\u0110T\/CN\/21\/24 - Qu\u1ef9 Ph\u00e1t tri\u1ec3n khoa h\u1ecdc v\u00e0 c\u00f4ng ngh\u1ec7 Qu\u1ed1c gia\" \/>\r\n<meta property=\"og:description\" content=\"Chi\u1ec1u ng\u00e0y 23\/12\/2025, B\u1ed9 Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 \u0111\u00e3 t\u1ed5 ch\u1ee9c phi\u00ean h\u1ecdp H\u1ed9i \u0111\u1ed3ng \u0111\u00e1nh gi\u00e1, nghi\u1ec7m thu k\u1ebft qu\u1ea3 th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0 \u201cNghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn gi\u1ed1ng l\u00faa v\u1ec1 vi ch\u1ea5t dinh d\u01b0\u1ee1ng b\u1eb1ng c\u00f4ng ngh\u1ec7 sinh h\u1ecdc\u201d – m\u00e3 s\u1ed1 N\u0110T\/CN\/21\/24. H\u1ed9i \u0111\u1ed3ng \u0111\u00e1nh gi\u00e1, nghi\u1ec7m thu nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0 \u201cNghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn gi\u1ed1ng l\u00faa v\u1ec1 vi ch\u1ea5t dinh d\u01b0\u1ee1ng b\u1eb1ng c\u00f4ng ngh\u1ec7 sinh h\u1ecdc\u201d – m\u00e3 s\u1ed1 N\u0110T\/CN\/21\/24 H\u1ed9i \u0111\u1ed3ng nghi\u1ec7m thu nhi\u1ec7m v\u1ee5 g\u1ed3m c\u00f3\u00a009\u00a0th\u00e0nh vi\u00ean do\u00a0GS.TS. Nguy\u1ec5n Huy Ho\u00e0ng, Vi\u1ec7n Sinh h\u1ecdc, Vi\u1ec7n H\u00e0n l\u00e2m Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 Vi\u1ec7t Nam l\u00e0m Ch\u1ee7 t\u1ecbch H\u1ed9i\u00a0\u0111\u1ed3ng v\u00e0 GS.TS. Tr\u1ea7n \u0110\u00ecnh Long, H\u1ed9i Gi\u1ed1ng c\u00e2y tr\u1ed3ng Vi\u1ec7t Nam l\u00e0m Ph\u00f3 ch\u1ee7 t\u1ecbch H\u1ed9i \u0111\u1ed3ng. Nhi\u1ec7m v\u1ee5 \u201cNghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn gi\u1ed1ng l\u00faa v\u1ec1 vi ch\u1ea5t dinh d\u01b0\u1ee1ng b\u1eb1ng c\u00f4ng ngh\u1ec7 sinh h\u1ecdc\u201d \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n t\u1eeb ng\u00e0y 02 th\u00e1ng 07 n\u0103m 2021 tr\u00ean c\u01a1 s\u1edf Quy\u1ebft \u0111\u1ecbnh s\u1ed1 959\/Q\u0110- BKHCN ng\u00e0y 26\/04\/2021 c\u1ee7a B\u1ed9 tr\u01b0\u1edfng B\u1ed9 Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 ph\u00ea duy\u1ec7t t\u1ed5 ch\u1ee9c ch\u1ee7 tr\u00ec, c\u00e1 nh\u00e2n ch\u1ee7 nhi\u1ec7m, kinh ph\u00ed, th\u1eddi gian th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0. Theo \u0111\u00f3, nhi\u1ec7m v\u1ee5 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n d\u01b0\u1edbi s\u1ef1 ch\u1ee7 tr\u00ec c\u1ee7a Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc T\u1ef1 nhi\u00ean, \u0110\u1ea1i h\u1ecdc Qu\u1ed1c gia H\u00e0 N\u1ed9i, do TS. L\u00ea Qu\u1ef3nh Mai l\u00e0 ch\u1ee7 nhi\u1ec7m nhi\u1ec7m v\u1ee5 v\u1edbi m\u1ee5c ti\u00eau ch\u00ednh l\u00e0: C\u1ea3i ti\u1ebfn \u0111\u01b0\u1ee3c h\u00e0m l\u01b0\u1ee3ng vi ch\u1ea5t dinh d\u01b0\u1ee1ng (t\u0103ng h\u00e0m l\u01b0\u1ee3ng Fe\/Zn) v\u00e0 gi\u1ea3m h\u00e0m l\u01b0\u1ee3ng Cd b\u1eb1ng c\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda h\u1ec7 gen, nh\u1eb1m n\u00e2ng cao gi\u00e1 tr\u1ecb c\u1ee7a l\u00faa g\u1ea1o. Nhi\u1ec7m v\u1ee5 \u0111\u00e3 \u00e1p d\u1ee5ng c\u00f4ng ngh\u1ec7 CRISPR\/Cas9 v\u1edbi c\u00e1c \u01b0u \u0111i\u1ec3m ch\u00ednh l\u00e0 can thi\u1ec7p ch\u00ednh x\u00e1c t\u1edbi v\u1ecb tr\u00ed mong mu\u1ed1n tr\u00ean h\u1ec7 gene, \u0111\u1ed9 \u0111\u1eb7c hi\u1ec7u cao v\u00e0 h\u1ea1n ch\u1ebf l\u01b0\u1ee3ng DNA ngo\u1ea1i lai t\u1ed3n t\u1ea1i trong c\u00e1c d\u00f2ng ch\u1ec9nh s\u1eeda. Th\u00e0nh vi\u00ean H\u1ed9i \u0111\u1ed3ng nh\u1eadn x\u00e9t nhi\u1ec7m v\u1ee5 Sau 48 th\u00e1ng tri\u1ec3n khai, nhi\u1ec7m v\u1ee5 \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng k\u1ebft qu\u1ea3 \u0111\u00e1ng ghi nh\u1eadn: – Thi\u1ebft k\u1ebf \u0111\u01b0\u1ee3c 04 c\u1ea5u tr\u00fac CRISPR\/Cas9 mang y\u1ebfu t\u1ed1 ch\u1ec9nh s\u1eeda h\u1ec7 gen li\u00ean quan \u0111\u1ebfn t\u0103ng kh\u1ea3 n\u0103ng t\u00edch l\u0169y vi ch\u1ea5t dinh d\u01b0\u1ee1ng (Fe\/Zn) v\u00e0 gi\u1ea3m h\u1ea5p thu c\u00e1c kim lo\u1ea1i n\u1eb7ng (Cd) ph\u00f9 h\u1ee3p \u0111\u1ec3 ch\u1ec9nh s\u1eeda h\u1ec7 gen v\u1edbi gi\u1ed1ng l\u00faa m\u1ee5c ti\u00eau \u0111\u01b0\u1ee3c ch\u1ecdn l\u00e0 TBR225. Trong \u0111\u00f3 c, c\u00e1c c\u1ea5u tr\u00fac ch\u1ec9nh s\u1eeda v\u1edbi c\u00e1c gen \u0111\u00edch OsNRAMP2, OsNRAMP5 \u0111\u00e3 \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf v\u1edbi m\u1ee5c ti\u00eau g\u00e2y \u0111\u1ed9t bi\u1ebfn gen; C\u1ea5u tr\u00fac s\u1eed d\u1ee5ng h\u1ec7 th\u1ed1ng s\u1eeda ch\u1eefa t\u01b0\u01a1ng \u0111\u1ed3ng c\u1ee7a CRISPR \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng bi\u1ec3u hi\u1ec7n gen OsNRAMP7 v\u00e0 C\u1ea5u tr\u00fac s\u1eed d\u1ee5ng ho\u1ea1t t\u00ednh b\u00e1m m\u00e0 kh\u00f4ng s\u1eed d\u1ee5ng ho\u1ea1t t\u00ednh c\u1eaft c\u1ee7a Cas9 v\u1edbi gen \u0111\u00edch OsYSL2 – Thi\u1ebft l\u1eadp \u0111\u01b0\u1ee3c Quy tr\u00ecnh ch\u1ec9nh s\u1eeda h\u1ec7 gen li\u00ean quan \u0111\u1ebfn vi ch\u1ea5t dinh d\u01b0\u1ee1ng \u1edf l\u00faa tr\u00ean c\u01a1 s\u1edf nghi\u00ean c\u1ee9u quy tr\u00ecnh ch\u1ec9nh s\u1eeda gen OsNRAMP5 \u1edf gi\u1ed1ng l\u00faa TBR225. Quy tr\u00ecnh \u0111\u1ea1t hi\u1ec7u su\u1ea5t t\u00e1i sinh 16,51% (t\u00ednh tr\u00ean t\u1ed5ng s\u1ed1 m\u00f4 s\u1eb9o), hi\u1ec7u su\u1ea5t chuy\u1ec3n gen 38,46% (t\u00ednh tr\u00ean t\u1ed5ng s\u1ed1 c\u00e2y t\u00e1i sinh) v\u00e0 hi\u1ec7u su\u1ea5t ch\u1ec9nh s\u1eeda gen \u0111\u00edch 30% (t\u00ednh tr\u00ean t\u1ed5ng s\u1ed1 c\u00e2y mang gen chuy\u1ec3n). – Thu \u0111\u01b0\u1ee3c 03 d\u00f2ng l\u00faa \u0111\u1ed9t bi\u1ebfn gen OsNRAMP5 c\u00f3 h\u00e0m l\u01b0\u1ee3ng Cd gi\u1ea3m v\u00e0 01 d\u00f2ng l\u00faa t\u0103ng c\u01b0\u1eddng bi\u1ec3u hi\u1ec7n gen OsNRAMP7 c\u00f3 h\u00e0m l\u01b0\u1ee3ng Fe, Zn t\u0103ng v\u00e0 h\u00e0m l\u01b0\u1ee3ng Cd gi\u1ea3m. C\u00e1c m\u1eabu h\u1ea1t c\u1ee7a c\u00e1c d\u00f2ng l\u00faa ch\u1ec9nh s\u1eeda gen – s\u1ea3n ph\u1ea9m c\u1ee7a \u0111\u1ec1 t\u00e0i Trong qu\u00e1 tr\u00ecnh th\u1ef1c hi\u1ec7n, Nhi\u1ec7m v\u1ee5 \u0111\u00e3 c\u00f4ng b\u1ed1 04 b\u00e0i b\u00e1o tr\u00ean t\u1ea1p ch\u00ed qu\u1ed1c t\u1ebf thu\u1ed9c danh m\u1ee5c Scopus, 03b\u00e0i b\u00e1o tr\u00ean t\u1ea1p ch\u00ed khoa h\u1ecdc trong n\u01b0\u1edbc v\u00e0 01 b\u00e0i to\u00e0n v\u0103n tr\u00ean K\u1ef7 y\u1ebfu h\u1ed9i ngh\u1ecb C\u00f4ng ngh\u1ec7 sinh h\u1ecdc to\u00e0n qu\u1ed1c; \u0111\u1ed3ng th\u1eddi \u0111\u00e0o t\u1ea1o th\u00e0nh c\u00f4ng 03 th\u1ea1c s\u0129. V\u1edbi vai tr\u00f2 l\u00e0 m\u1ed9t nhi\u1ec7m v\u1ee5 theo ngh\u1ecb \u0111\u1ecbnh th\u01b0, nhi\u1ec7m v\u1ee5 \u0111\u00e3 th\u00fac \u0111\u1ea9y t\u0103ng c\u01b0\u1eddng h\u1ee3p t\u00e1c qu\u1ed1c t\u1ebf, \u0111\u1eb7c bi\u1ec7t v\u1edbi \u0111\u1ed1i t\u00e1c l\u00e0 Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc N\u00f4ng nghi\u1ec7p Nam Kinh, Giang T\u00f4, Trung Qu\u1ed1c. Ph\u00eda \u0111\u1ed1i t\u00e1c \u0111\u00e3 h\u1ed7 tr\u1ee3 v\u1eadt li\u1ec7u v\u00e0 ph\u1ed5 bi\u1ebfn k\u1ef9 thu\u1eadt \u0111\u1ec3 nh\u00f3m nghi\u00ean c\u1ee9u b\u01b0\u1edbc \u0111\u1ea7u tri\u1ec3n khai ch\u1ec9nh s\u1eeda \u0111a gen, m\u1ed9t h\u01b0\u1edbng nghi\u00ean c\u1ee9u ti\u1ec1m n\u0103ng trong l\u0129nh v\u1ef1c ph\u00e1t tri\u1ec3n ch\u1ecdn t\u1ea1o gi\u1ed1ng c\u00e2y tr\u1ed3ng. Ch\u1ee7 nhi\u1ec7m nhi\u1ec7m v\u1ee5 ph\u00eda Vi\u1ec7t Nam – TS. L\u00ea Qu\u1ef3nh Mai v\u00e0 PGS.TS. Chen Xi, Vice-Dean of College of Life Science, \u0110\u1ea1i h\u1ecdc N\u00f4ng nghi\u1ec7p Nam Kinh. C\u00e1c th\u00e0nh vi\u00ean H\u1ed9i \u0111\u1ed3ng nghi\u1ec7m thu \u0111\u00e1nh gi\u00e1 cao c\u00e1c k\u1ebft qu\u1ea3 m\u00e0 nh\u00f3m th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5 \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c, ghi nh\u1eadn c\u00e1c s\u1ea3n ph\u1ea9m \u0111\u00e3 \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 ch\u1ee7ng lo\u1ea1i, s\u1ed1 l\u01b0\u1ee3ng, ch\u1ea5t l\u01b0\u1ee3ng so v\u1edbi \u0111\u1eb7t h\u00e0ng, s\u1ea3n ph\u1ea9m c\u00f4ng b\u1ed1 khoa h\u1ecdc v\u00e0 \u0111\u00e0o t\u1ea1o \u0111\u1ec1u v\u01b0\u1ee3t y\u00eau c\u1ea7u. Tr\u00ean c\u01a1 s\u1edf \u0111\u00f3, to\u00e0n th\u1ec3 9\/9 th\u00e0nh vi\u00ean h\u1ed9i \u0111\u1ed3ng \u0111\u1ec1u nh\u1ea5t tr\u00ed nghi\u1ec7m thu \u0111\u1ec1 t\u00e0i v\u1edbi m\u1ee9c “\u0110\u1ea1t”.\u00a0C\u00e1c th\u00e0nh vi\u00ean h\u1ed9i \u0111\u1ed3ng c\u0169ng \u0111\u00e3 g\u00f3p c\u00e1c \u00fd ki\u1ebfn x\u00e1c \u0111\u00e1ng \u0111\u1ec3 nh\u00f3m nghi\u00ean c\u1ee9u ch\u1ec9nh s\u1eeda, ho\u00e0n thi\u1ec7n h\u1ed3 s\u01a1 tr\u00ecnh B\u1ed9 Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 ra quy\u1ebft \u0111\u1ecbnh c\u00f4ng nh\u1eadn k\u1ebft qu\u1ea3 c\u1ee7a nhi\u1ec7m v\u1ee5.\/.  \" \/>\r\n<meta property=\"og:url\" content=\"https:\/\/nafosted.gov.vn\/nghiem-thu-nhiem-vu-khcn-theo-nghi-dinh-thu-ma-so-ndt-cn-21-24\/\" \/>\r\n<meta property=\"og:site_name\" content=\"Qu\u1ef9 Ph\u00e1t tri\u1ec3n khoa h\u1ecdc v\u00e0 c\u00f4ng ngh\u1ec7 Qu\u1ed1c gia\" \/>\r\n<meta property=\"article:published_time\" content=\"2025-12-26T10:09:02+00:00\" \/>\r\n<meta property=\"article:modified_time\" content=\"2026-01-14T10:17:36+00:00\" \/>\r\n<meta property=\"og:image\" content=\"https:\/\/nafosted.gov.vn\/wp-content\/uploads\/2026\/01\/01-1.jpg\" \/>\r\n\t<meta property=\"og:image:width\" content=\"1267\" \/>\r\n\t<meta property=\"og:image:height\" content=\"950\" \/>\r\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\r\n<meta name=\"author\" content=\"admin\" \/>\r\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\r\n<meta name=\"twitter:label1\" content=\"\u0110\u01b0\u1ee3c vi\u1ebft b\u1edfi\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u01af\u1edbc t\u00ednh th\u1eddi gian \u0111\u1ecdc\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 ph\u00fat\" \/>\r\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/nafosted.gov.vn\/nghiem-thu-nhiem-vu-khcn-theo-nghi-dinh-thu-ma-so-ndt-cn-21-24\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/nafosted.gov.vn\/nghiem-thu-nhiem-vu-khcn-theo-nghi-dinh-thu-ma-so-ndt-cn-21-24\/\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/nafosted.gov.vn\/#\/schema\/person\/0f3609cce95c0e113635c69e9cf26dbb\"},\"headline\":\"Nghi\u1ec7m thu nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0, m\u00e3 s\u1ed1 N\u0110T\/CN\/21\/24\",\"datePublished\":\"2025-12-26T10:09:02+00:00\",\"dateModified\":\"2026-01-14T10:17:36+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/nafosted.gov.vn\/nghiem-thu-nhiem-vu-khcn-theo-nghi-dinh-thu-ma-so-ndt-cn-21-24\/\"},\"wordCount\":1511,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/nafosted.gov.vn\/#organization\"},\"image\":{\"@id\":\"https:\/\/nafosted.gov.vn\/nghiem-thu-nhiem-vu-khcn-theo-nghi-dinh-thu-ma-so-ndt-cn-21-24\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/nafosted.gov.vn\/wp-content\/uploads\/2026\/01\/01-1.jpg\",\"articleSection\":[\"Th\u00f4ng tin k\u1ebft qu\u1ea3 th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5\",\"Tin t\u1ee9c\"],\"inLanguage\":\"vi\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/nafosted.gov.vn\/nghiem-thu-nhiem-vu-khcn-theo-nghi-dinh-thu-ma-so-ndt-cn-21-24\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/nafosted.gov.vn\/nghiem-thu-nhiem-vu-khcn-theo-nghi-dinh-thu-ma-so-ndt-cn-21-24\/\",\"url\":\"https:\/\/nafosted.gov.vn\/nghiem-thu-nhiem-vu-khcn-theo-nghi-dinh-thu-ma-so-ndt-cn-21-24\/\",\"name\":\"Nghi\u1ec7m thu nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0, m\u00e3 s\u1ed1 N\u0110T\/CN\/21\/24 - 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H\u1ed9i \u0111\u1ed3ng \u0111\u00e1nh gi\u00e1, nghi\u1ec7m thu nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0 \u201cNghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn gi\u1ed1ng l\u00faa v\u1ec1 vi ch\u1ea5t dinh d\u01b0\u1ee1ng b\u1eb1ng c\u00f4ng ngh\u1ec7 sinh h\u1ecdc\u201d – m\u00e3 s\u1ed1 N\u0110T\/CN\/21\/24 H\u1ed9i \u0111\u1ed3ng nghi\u1ec7m thu nhi\u1ec7m v\u1ee5 g\u1ed3m c\u00f3\u00a009\u00a0th\u00e0nh vi\u00ean do\u00a0GS.TS. Nguy\u1ec5n Huy Ho\u00e0ng, Vi\u1ec7n Sinh h\u1ecdc, Vi\u1ec7n H\u00e0n l\u00e2m Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 Vi\u1ec7t Nam l\u00e0m Ch\u1ee7 t\u1ecbch H\u1ed9i\u00a0\u0111\u1ed3ng v\u00e0 GS.TS. Tr\u1ea7n \u0110\u00ecnh Long, H\u1ed9i Gi\u1ed1ng c\u00e2y tr\u1ed3ng Vi\u1ec7t Nam l\u00e0m Ph\u00f3 ch\u1ee7 t\u1ecbch H\u1ed9i \u0111\u1ed3ng. Nhi\u1ec7m v\u1ee5 \u201cNghi\u00ean c\u1ee9u c\u1ea3i ti\u1ebfn gi\u1ed1ng l\u00faa v\u1ec1 vi ch\u1ea5t dinh d\u01b0\u1ee1ng b\u1eb1ng c\u00f4ng ngh\u1ec7 sinh h\u1ecdc\u201d \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n t\u1eeb ng\u00e0y 02 th\u00e1ng 07 n\u0103m 2021 tr\u00ean c\u01a1 s\u1edf Quy\u1ebft \u0111\u1ecbnh s\u1ed1 959\/Q\u0110- BKHCN ng\u00e0y 26\/04\/2021 c\u1ee7a B\u1ed9 tr\u01b0\u1edfng B\u1ed9 Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 ph\u00ea duy\u1ec7t t\u1ed5 ch\u1ee9c ch\u1ee7 tr\u00ec, c\u00e1 nh\u00e2n ch\u1ee7 nhi\u1ec7m, kinh ph\u00ed, th\u1eddi gian th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5 KH&CN theo Ngh\u1ecb \u0111\u1ecbnh th\u01b0. Theo \u0111\u00f3, nhi\u1ec7m v\u1ee5 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n d\u01b0\u1edbi s\u1ef1 ch\u1ee7 tr\u00ec c\u1ee7a Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Khoa h\u1ecdc T\u1ef1 nhi\u00ean, \u0110\u1ea1i h\u1ecdc Qu\u1ed1c gia H\u00e0 N\u1ed9i, do TS. L\u00ea Qu\u1ef3nh Mai l\u00e0 ch\u1ee7 nhi\u1ec7m nhi\u1ec7m v\u1ee5 v\u1edbi m\u1ee5c ti\u00eau ch\u00ednh l\u00e0: C\u1ea3i ti\u1ebfn \u0111\u01b0\u1ee3c h\u00e0m l\u01b0\u1ee3ng vi ch\u1ea5t dinh d\u01b0\u1ee1ng (t\u0103ng h\u00e0m l\u01b0\u1ee3ng Fe\/Zn) v\u00e0 gi\u1ea3m h\u00e0m l\u01b0\u1ee3ng Cd b\u1eb1ng c\u00f4ng ngh\u1ec7 ch\u1ec9nh s\u1eeda h\u1ec7 gen, nh\u1eb1m n\u00e2ng cao gi\u00e1 tr\u1ecb c\u1ee7a l\u00faa g\u1ea1o. Nhi\u1ec7m v\u1ee5 \u0111\u00e3 \u00e1p d\u1ee5ng c\u00f4ng ngh\u1ec7 CRISPR\/Cas9 v\u1edbi c\u00e1c \u01b0u \u0111i\u1ec3m ch\u00ednh l\u00e0 can thi\u1ec7p ch\u00ednh x\u00e1c t\u1edbi v\u1ecb tr\u00ed mong mu\u1ed1n tr\u00ean h\u1ec7 gene, \u0111\u1ed9 \u0111\u1eb7c hi\u1ec7u cao v\u00e0 h\u1ea1n ch\u1ebf l\u01b0\u1ee3ng DNA ngo\u1ea1i lai t\u1ed3n t\u1ea1i trong c\u00e1c d\u00f2ng ch\u1ec9nh s\u1eeda. Th\u00e0nh vi\u00ean H\u1ed9i \u0111\u1ed3ng nh\u1eadn x\u00e9t nhi\u1ec7m v\u1ee5 Sau 48 th\u00e1ng tri\u1ec3n khai, nhi\u1ec7m v\u1ee5 \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c nh\u1eefng k\u1ebft qu\u1ea3 \u0111\u00e1ng ghi nh\u1eadn: – Thi\u1ebft k\u1ebf \u0111\u01b0\u1ee3c 04 c\u1ea5u tr\u00fac CRISPR\/Cas9 mang y\u1ebfu t\u1ed1 ch\u1ec9nh s\u1eeda h\u1ec7 gen li\u00ean quan \u0111\u1ebfn t\u0103ng kh\u1ea3 n\u0103ng t\u00edch l\u0169y vi ch\u1ea5t dinh d\u01b0\u1ee1ng (Fe\/Zn) v\u00e0 gi\u1ea3m h\u1ea5p thu c\u00e1c kim lo\u1ea1i n\u1eb7ng (Cd) ph\u00f9 h\u1ee3p \u0111\u1ec3 ch\u1ec9nh s\u1eeda h\u1ec7 gen v\u1edbi gi\u1ed1ng l\u00faa m\u1ee5c ti\u00eau \u0111\u01b0\u1ee3c ch\u1ecdn l\u00e0 TBR225. Trong \u0111\u00f3 c, c\u00e1c c\u1ea5u tr\u00fac ch\u1ec9nh s\u1eeda v\u1edbi c\u00e1c gen \u0111\u00edch OsNRAMP2, OsNRAMP5 \u0111\u00e3 \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf v\u1edbi m\u1ee5c ti\u00eau g\u00e2y \u0111\u1ed9t bi\u1ebfn gen; C\u1ea5u tr\u00fac s\u1eed d\u1ee5ng h\u1ec7 th\u1ed1ng s\u1eeda ch\u1eefa t\u01b0\u01a1ng \u0111\u1ed3ng c\u1ee7a CRISPR \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng bi\u1ec3u hi\u1ec7n gen OsNRAMP7 v\u00e0 C\u1ea5u tr\u00fac s\u1eed d\u1ee5ng ho\u1ea1t t\u00ednh b\u00e1m m\u00e0 kh\u00f4ng s\u1eed d\u1ee5ng ho\u1ea1t t\u00ednh c\u1eaft c\u1ee7a Cas9 v\u1edbi gen \u0111\u00edch OsYSL2 – Thi\u1ebft l\u1eadp \u0111\u01b0\u1ee3c Quy tr\u00ecnh ch\u1ec9nh s\u1eeda h\u1ec7 gen li\u00ean quan \u0111\u1ebfn vi ch\u1ea5t dinh d\u01b0\u1ee1ng \u1edf l\u00faa tr\u00ean c\u01a1 s\u1edf nghi\u00ean c\u1ee9u quy tr\u00ecnh ch\u1ec9nh s\u1eeda gen OsNRAMP5 \u1edf gi\u1ed1ng l\u00faa TBR225. Quy tr\u00ecnh \u0111\u1ea1t hi\u1ec7u su\u1ea5t t\u00e1i sinh 16,51% (t\u00ednh tr\u00ean t\u1ed5ng s\u1ed1 m\u00f4 s\u1eb9o), hi\u1ec7u su\u1ea5t chuy\u1ec3n gen 38,46% (t\u00ednh tr\u00ean t\u1ed5ng s\u1ed1 c\u00e2y t\u00e1i sinh) v\u00e0 hi\u1ec7u su\u1ea5t ch\u1ec9nh s\u1eeda gen \u0111\u00edch 30% (t\u00ednh tr\u00ean t\u1ed5ng s\u1ed1 c\u00e2y mang gen chuy\u1ec3n). – Thu \u0111\u01b0\u1ee3c 03 d\u00f2ng l\u00faa \u0111\u1ed9t bi\u1ebfn gen OsNRAMP5 c\u00f3 h\u00e0m l\u01b0\u1ee3ng Cd gi\u1ea3m v\u00e0 01 d\u00f2ng l\u00faa t\u0103ng c\u01b0\u1eddng bi\u1ec3u hi\u1ec7n gen OsNRAMP7 c\u00f3 h\u00e0m l\u01b0\u1ee3ng Fe, Zn t\u0103ng v\u00e0 h\u00e0m l\u01b0\u1ee3ng Cd gi\u1ea3m. C\u00e1c m\u1eabu h\u1ea1t c\u1ee7a c\u00e1c d\u00f2ng l\u00faa ch\u1ec9nh s\u1eeda gen – s\u1ea3n ph\u1ea9m c\u1ee7a \u0111\u1ec1 t\u00e0i Trong qu\u00e1 tr\u00ecnh th\u1ef1c hi\u1ec7n, Nhi\u1ec7m v\u1ee5 \u0111\u00e3 c\u00f4ng b\u1ed1 04 b\u00e0i b\u00e1o tr\u00ean t\u1ea1p ch\u00ed qu\u1ed1c t\u1ebf thu\u1ed9c danh m\u1ee5c Scopus, 03b\u00e0i b\u00e1o tr\u00ean t\u1ea1p ch\u00ed khoa h\u1ecdc trong n\u01b0\u1edbc v\u00e0 01 b\u00e0i to\u00e0n v\u0103n tr\u00ean K\u1ef7 y\u1ebfu h\u1ed9i ngh\u1ecb C\u00f4ng ngh\u1ec7 sinh h\u1ecdc to\u00e0n qu\u1ed1c; \u0111\u1ed3ng th\u1eddi \u0111\u00e0o t\u1ea1o th\u00e0nh c\u00f4ng 03 th\u1ea1c s\u0129. V\u1edbi vai tr\u00f2 l\u00e0 m\u1ed9t nhi\u1ec7m v\u1ee5 theo ngh\u1ecb \u0111\u1ecbnh th\u01b0, nhi\u1ec7m v\u1ee5 \u0111\u00e3 th\u00fac \u0111\u1ea9y t\u0103ng c\u01b0\u1eddng h\u1ee3p t\u00e1c qu\u1ed1c t\u1ebf, \u0111\u1eb7c bi\u1ec7t v\u1edbi \u0111\u1ed1i t\u00e1c l\u00e0 Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc N\u00f4ng nghi\u1ec7p Nam Kinh, Giang T\u00f4, Trung Qu\u1ed1c. Ph\u00eda \u0111\u1ed1i t\u00e1c \u0111\u00e3 h\u1ed7 tr\u1ee3 v\u1eadt li\u1ec7u v\u00e0 ph\u1ed5 bi\u1ebfn k\u1ef9 thu\u1eadt \u0111\u1ec3 nh\u00f3m nghi\u00ean c\u1ee9u b\u01b0\u1edbc \u0111\u1ea7u tri\u1ec3n khai ch\u1ec9nh s\u1eeda \u0111a gen, m\u1ed9t h\u01b0\u1edbng nghi\u00ean c\u1ee9u ti\u1ec1m n\u0103ng trong l\u0129nh v\u1ef1c ph\u00e1t tri\u1ec3n ch\u1ecdn t\u1ea1o gi\u1ed1ng c\u00e2y tr\u1ed3ng. Ch\u1ee7 nhi\u1ec7m nhi\u1ec7m v\u1ee5 ph\u00eda Vi\u1ec7t Nam – TS. L\u00ea Qu\u1ef3nh Mai v\u00e0 PGS.TS. Chen Xi, Vice-Dean of College of Life Science, \u0110\u1ea1i h\u1ecdc N\u00f4ng nghi\u1ec7p Nam Kinh. C\u00e1c th\u00e0nh vi\u00ean H\u1ed9i \u0111\u1ed3ng nghi\u1ec7m thu \u0111\u00e1nh gi\u00e1 cao c\u00e1c k\u1ebft qu\u1ea3 m\u00e0 nh\u00f3m th\u1ef1c hi\u1ec7n nhi\u1ec7m v\u1ee5 \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c, ghi nh\u1eadn c\u00e1c s\u1ea3n ph\u1ea9m \u0111\u00e3 \u0111\u1ea7y \u0111\u1ee7 v\u1ec1 ch\u1ee7ng lo\u1ea1i, s\u1ed1 l\u01b0\u1ee3ng, ch\u1ea5t l\u01b0\u1ee3ng so v\u1edbi \u0111\u1eb7t h\u00e0ng, s\u1ea3n ph\u1ea9m c\u00f4ng b\u1ed1 khoa h\u1ecdc v\u00e0 \u0111\u00e0o t\u1ea1o \u0111\u1ec1u v\u01b0\u1ee3t y\u00eau c\u1ea7u. Tr\u00ean c\u01a1 s\u1edf \u0111\u00f3, to\u00e0n th\u1ec3 9\/9 th\u00e0nh vi\u00ean h\u1ed9i \u0111\u1ed3ng \u0111\u1ec1u nh\u1ea5t tr\u00ed nghi\u1ec7m thu \u0111\u1ec1 t\u00e0i v\u1edbi m\u1ee9c “\u0110\u1ea1t”.\u00a0C\u00e1c th\u00e0nh vi\u00ean h\u1ed9i \u0111\u1ed3ng c\u0169ng \u0111\u00e3 g\u00f3p c\u00e1c \u00fd ki\u1ebfn x\u00e1c \u0111\u00e1ng \u0111\u1ec3 nh\u00f3m nghi\u00ean c\u1ee9u ch\u1ec9nh s\u1eeda, ho\u00e0n thi\u1ec7n h\u1ed3 s\u01a1 tr\u00ecnh B\u1ed9 Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 ra quy\u1ebft \u0111\u1ecbnh c\u00f4ng nh\u1eadn k\u1ebft qu\u1ea3 c\u1ee7a nhi\u1ec7m v\u1ee5.\/.  ","og_url":"https:\/\/nafosted.gov.vn\/nghiem-thu-nhiem-vu-khcn-theo-nghi-dinh-thu-ma-so-ndt-cn-21-24\/","og_site_name":"Qu\u1ef9 Ph\u00e1t tri\u1ec3n khoa h\u1ecdc v\u00e0 c\u00f4ng ngh\u1ec7 Qu\u1ed1c 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