{"id":1698,"date":"2014-08-25T10:02:01","date_gmt":"2014-08-25T03:02:01","guid":{"rendered":"http:\/\/antoansinhhoc.vn\/?p=1698"},"modified":"2014-08-25T10:02:01","modified_gmt":"2014-08-25T03:02:01","slug":"co-so-cau-truc-cua-noi-virus-gay-benh-kham-ca-chua-va-su-dap-ung-voi-gen-khang-tm-1","status":"publish","type":"post","link":"https:\/\/nbca.gov.vn\/co-so-cau-truc-cua-noi-virus-gay-benh-kham-ca-chua-va-su-dap-ung-voi-gen-khang-tm-1\/","title":{"rendered":"C\u01a1 s\u1edf c\u1ea5u tr\u00fac c\u1ee7a n\u00f2i virus g\u00e2y b\u1ec7nh kh\u1ea3m c\u00e0 chua v\u00e0 s\u1ef1 \u0111\u00e1p \u1ee9ng v\u1edbi gen kh\u00e1ng Tm-1"},"content":{"rendered":"<div class=\"TomTat clearfix\">\n<p><span id=\"ArticalDetail1_lblTeaser\" class=\"OverollContentDesc\">Kazuhiro\u00a0Ishibashi v\u00e0 ctv. (2014) \u0111\u00e3 c\u00f4ng b\u1ed1 k\u1ebf qu\u1ea3 c\u00f4ng tr\u00ecnh n\u00e0y tr\u00ean t\u1ea1p ch\u00ed PNAS, August 19, 2014; Vol.111; No.33 E3486-E3495. Gi\u1ea3 thuy\u1ebft Red Queen cho r\u1eb1ng c\u00e1c gen c\u00f3 ch\u1ee9c n\u0103ng trong ph\u1ea3n \u1ee9ng t\u1ef1 v\u1ec7 c\u1ee7a c\u00e2y ch\u1ee7 \u0111\u00e3 ti\u1ebfn h\u00f3a \u0111\u1ec3 ch\u1ed1ng l\u1ea1i c\u00e1c \u1ea3nh h\u01b0\u1edfng b\u1ea5t l\u1ee3i c\u1ee7a virus g\u00e2y b\u1ec7nh, v\u00ec ch\u00fang c\u0169ng \u0111ang trong qu\u00e1 tr\u00ecnh ti\u1ebfn h\u00f3a nhanh ch\u00f3ng.\u00a0<\/span>\u0110\u0103ng ng\u00e0y <span id=\"ArticalDetail1_lblDate\">25-08-2014<\/span> trong chuy\u00ean m\u1ee5c <a id=\"ArticalDetail1_lnkChuyenmuc\" href=\"http:\/\/antoansinhhoc.vn\/Chuyen-muc\/Tin-the-gioi\/260\/1\">Tin th\u1ebf gi\u1edbi<\/a><\/p>\n<\/div>\n<div class=\"NoiDungBai\">\n<p>Cho d\u00f9 c\u1ea5u tr\u00fac 3D c\u1ee7a c\u00e1c ph\u1ee9c protein gi\u1eefa c\u00e2y ch\u1ee7 v\u00e0 virus \u0111\u00e3 cung c\u1ea5p cho ch\u00fang ta nh\u1eefng hi\u1ec3u bi\u1ebft v\u00f4 c\u00f9ng to l\u1edbn v\u1ec1 c\u00e1c xung \u0111\u1ed9t \u1edf m\u1ee9c \u0111\u1ed9 ph\u00e2n t\u1eed gi\u1eefa ch\u00fang, nh\u01b0ng th\u1eadt ra ch\u1ec9 c\u00f3 m\u1ed9t c\u1ea5u tr\u00fac \u0111\u01a1n bi\u1ec3u tr\u01b0ng cho m\u1ed9t\u00a0<strong>snapshot<\/strong>\u00a0(ki\u1ec3u c\u1ea5u tr\u00fac b\u1ea5t ch\u1ee3t n\u00e0o \u0111\u00f3) c\u00f3 t\u00ednh ch\u1ea5t ti\u1ebfn h\u00f3a. T\u00e1c gi\u1ea3 \u0111\u00e3 gi\u1edbi thi\u1ec7u nh\u1eefng chi ti\u1ebft c\u1edf m\u1ee9c \u0111\u1ed9 nguy\u00ean t\u1eed c\u1ee7a c\u00e1i g\u1ecdi l\u00e0 \u201c<strong>step-by-step arms race<\/strong>\u201d (n\u00f2i virus x\u1ebfp theo c\u00e2y ph\u00e2n nh\u00e1nh t\u1eebng b\u01b0\u1edbc m\u1ed9t) gi\u1eefa protein c\u00f3 t\u00ednh ch\u1ea5t t\u1ef1 t\u00e1i b\u1ea3n c\u1ee7a virus g\u00e2y b\u1ec7nh kh\u1ea3m v\u00e0 protein c\u00f3 t\u00ednh ch\u1ea5t \u1ee9c ch\u1ebf c\u1ee7a c\u00e2y ch\u1ee7\u00a0<strong>Tm-1<\/strong>, trong \u0111\u00f3, s\u1ef1 ph\u00e1t hi\u1ec7n c\u1ee7a c\u00e2y ch\u1ee7\u00a0 \u0111\u1ed1i v\u1edbi m\u1ed9t ph\u00e2n t\u1eed virus (viral molecule), \u0111\u1ed1i v\u1edbi s\u1ef1 x\u00e2m nhi\u1ec5m c\u00f3 t\u00ednh ch\u1ea5t t\u01b0\u01a1ng h\u1ee3p c\u1ee7a virus (viral adaptive evasion), s\u1ef1 ph\u1ea3n \u1ee9ng ch\u1ed1ng l\u1ea1i c\u00f3 t\u00ednh ch\u1ea5t t\u01b0\u01a1ng h\u1ee3p c\u1ee7a c\u00e2y ch\u1ee7, v\u00e0 ph\u1ea3n \u1ee9ng ch\u1ed1ng l\u1ea1i c\u1ee7a virus \u0111\u00e3 \u0111\u01b0\u1ee3c mi\u00eau t\u1ea3 kh\u00e1 k\u1ef9 th\u00f4ng qua vi\u1ec7c x\u00e1c \u0111\u1ecbnh nh\u1eefng c\u1ea5u tr\u00fac v\u00f4 c\u00f9ng ph\u1ee9c t\u1ea1p \u1ea5y c\u1ee7a nh\u1eefng bi\u1ebfn th\u1ec3 Tm-1 (<strong>Tm-1 variants<\/strong>) v\u00e0 protein c\u1ee7a virus. Ng\u01b0\u1eddi ta c\u00f2n th\u00f4ng qua c\u00e1c ph\u00e2n t\u00edch sinh h\u00f3a v\u00e0 ph\u01b0\u01a1ng ph\u00e1p m\u00f4 ph\u1ecfng \u0111\u1ed9ng th\u00e1i \u1edf m\u1ee9c \u0111\u1ed9 ph\u00e2n t\u1eed c\u1ee7a c\u00e1c t\u01b0\u01a1ng t\u00e1c gi\u1eefa nh\u1eefng protein nh\u01b0 v\u1eady.<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" title=\"Tu\u1ea7n tin khoa h\u1ecdc 394 (25 - 31\/08\/2014)\" src=\"http:\/\/iasvn.org\/Images_upload\/images\/New%20Picture%20(40)(11).png\" alt=\"\" \/><\/p>\n<p><u>H\u00ecnh 1<\/u>. C\u1ea5u tr\u00fac c\u1ee7a domain\u00a0<strong>N-terminal inhibitory<\/strong>\u00a0\u201c<strong>Tm-1<\/strong>\u201d.<\/p>\n<p>A) T\u1ed5 ch\u1ee9c c\u1ee7a domain Tm-1 v\u1edbi c\u00e1c domains\u00a0<strong>NN<\/strong>\u00a0v\u00e0\u00a0<strong>NC<\/strong>\u00a0c\u00f3 m\u00e0u xanh d\u01b0\u01a1ng. Domuain\u00a0<strong>C-terminal<\/strong>\u00a0c\u00f3 m\u00e0u xanh l\u1ee5c. C\u00e1c v\u1ecb tr\u00ed c\u1ee7a g\u1ed1c (residue positions) m\u00e0 v\u1ecb tr\u00ed n\u00e0y x\u00e1c \u0111\u1ecbnh ranh gi\u1edbi c\u1ee7a domain c\u0169ng \u0111\u01b0\u1ee3c ghi nh\u1eadn. \u0111\u01b0\u1eddng m\u00e0u \u0111\u1ecf bi\u1ec3u th\u1ecb sequence c\u00f3 k\u1ebft qu\u1ea3 ch\u1ecdn l\u1ecdc t\u00edch c\u1ef1c.<\/p>\n<p>(B) C\u1ea5u tr\u00fac 3D c\u1ee7a Tm-1(431) bi\u1ec3u th\u1ecb \u201cribbon diagram\u201d. Ph\u00e2n bi\u1ec7t gi\u1eefa hai chu\u1ed7i polypeptide c\u1ee7a\u00a0<strong>Tm-1 homodimer<\/strong>\u00a0c\u0103n c\u1ee9 tr\u00ean m\u00e0u xanh d\u01b0\u01a1ng, v\u00e0 m\u00e0u l\u1ee5c lam (cyan). C\u00e1c g\u1ed1c\u00a0<strong>T79\u2013D112<\/strong>, v\u1edbi k\u1ebft qu\u1ea3 ch\u1ecdn l\u1ecdc t\u00edch c\u1ef1c, c\u00f3 m\u00e0u \u0111\u1ecf. C\u00e1c sequences kh\u00f4ng c\u00f3 m\u1eadt \u0111\u1ed9 electron mang t\u00ednh ch\u1ea5t gi\u1ea3i th\u00edch \u0111\u01b0\u1ee3c (interpretable) (S39\u2013K45, L80\u2013A89, v\u00e0 S202\u2013G210) \u0111\u01b0\u1ee3c bi\u1ec3u th\u1ecb b\u1eb1ng \u0111\u01b0\u1eddng ch\u1ea5m ch\u1ea5m. T\u1ea5t c\u1ea3 c\u1ea5u tr\u00fac trong h\u00ecnh n\u00e0y \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1eb1ng\u00a0<strong>PyMol<\/strong>\u00a0(32).<\/p>\n<p>(C) H\u00ecnh h\u1ecdc t\u00f4 p\u00f4 (topology) c\u1ee7a Tm-1(431): \u03b1-Helices bi\u1ec3u th\u1ecb b\u1eb1ng h\u00ecnh tr\u1ee5 c\u00f3 m\u00e0u \u0111\u1ecf t\u01b0\u01a1i (magenta) v\u00e0 \u03b2-sheets l\u00e0 m\u0169i t\u00ean c\u00f3 m\u00e0u l\u1ee5c lam (cyan). Diagram n\u00e0y \u0111\u01b0\u1ee3c v\u1ebd b\u1eb1ng\u00a0<strong>TopDraw<\/strong>\u00a0(33).<\/p>\n<p>(D) Ho\u1ea1t \u0111\u1ed9ng \u1ee9c ch\u1ebf c\u1ee7a Tm-1(431), Tm-1(201), v\u00e0 th\u1ec3 \u0111\u1ed9t bi\u1ebfn c\u1ee7a ch\u00fang I91T tr\u00ean s\u1ef1 t\u1ef1 t\u00e1i b\u1ea3n ToMV RNA\u00a0<em>in vitro<\/em>. Ph\u00e2n t\u1eed RNAs c\u1ee7a WT ToMV, LT1, v\u00e0 c\u00e1c ch\u1ee7ng n\u00f2i (strains) LT1 (E979K) \u0111\u01b0\u1ee3c gi\u1ea3i m\u00e3 v\u00e0 t\u1ef1 t\u00e1i b\u1ea3n\u00a0<em>in vitro<\/em>\u00a0khi bi\u1ec3u hi\u1ec7n c\u00e1c d\u1eabn xu\u1ea5t\u00a0<strong>Tm-1<\/strong>. S\u1ef1 tr\u1ed9n v\u00e0o c\u1ee7a [\u03b1-32 P] CTP trong ph\u00e2n t\u1eed RNA (G) t\u1ed5ng h\u1ee3p v\u00e0 d\u1ea1ng t\u00e1i t\u1ed5 h\u1ee3p RNA (RF) \u0111\u01b0\u1ee3c bi\u1ec3u hi\u1ec7n qua k\u1ebft qu\u1ea3 \u0111i\u1ec7n di.<\/p>\n<p>&nbsp;<\/p>\n<p>Gen kh\u00e1ng virus g\u00e2y b\u1ec7nh kh\u1ea3m c\u00e0 chua\u00a0<em><strong>Tm-1<\/strong><\/em>\u00a0\u00a0(tomato mosaic virus: vi\u1ebft t\u1eaft l\u00e0\u00a0<strong>ToMV<\/strong>) m\u00e3 h\u00f3a m\u1ed9t protein bi\u1ec3u th\u1ecb kh\u00f4ng \u0111\u1ed3ng d\u1ea1ng v\u1ec1 tr\u00ecnh t\u1ef1 DNA c\u1ee7a n\u00f3 \u0111\u1ec3 kh\u1eb3ng \u0111\u1ecbnh nh\u1eefng protein c\u00f3 ch\u1ee9c n\u0103ng kh\u00e1c nhau.\u00a0<strong>Tm-1 binds ToMV replication proteins<\/strong>\u00a0(nh\u1eefng protein t\u1ef1 t\u00e1i b\u1ea3n Tm-1 g\u1eafn v\u1edbi ToMV) t\u1ea1o ra s\u1ef1 ki\u1ec7n \u1ee9c ch\u1ebf s\u1ef1 h\u00ecnh th\u00e0nh ph\u1ee9c protein c\u00f3 t\u00ednh ch\u1ea5t t\u1ef1 t\u00e1i b\u1ea3n. Nh\u1eefng th\u1ec3 \u0111\u1ed9t bi\u1ebfn c\u1ee7a ToMV \u0111\u00e3 kh\u1eafc ph\u1ee5c \u0111\u01b0\u1ee3c t\u00ednh kh\u00e1ng n\u00e0y, ch\u00fang c\u00f3 s\u1ef1 thay th\u1ebf c\u00e1c amino acidtrong domain c\u1ee7a enzyme \u201c<strong>helicase<\/strong>\u201d c\u1ee7a protein t\u1ef1 t\u00e1i b\u1ea3n (<strong>ToMV-Hel<\/strong>). M\u1ed9t v\u00f9ng r\u1ea5t nh\u1ecf n\u01a1i gen\u00a0<em><strong>Tm-1<\/strong><\/em>\u00a0\u0111\u1ecbnh v\u1ecb trong genome c\u1ee7a lo\u00e0i c\u00e0 chua hoang d\u1ea1i\u00a0<em><strong>Solanum habrochaites<\/strong><\/em>\u00a0\u0111\u00e3 bi\u1ec7u hi\u1ec7n \u0111\u01b0\u1ee3c k\u1ebft qu\u1ea3 ch\u1ecdn l\u1ecdc t\u00edch c\u1ef1c (positive selection) trong qu\u00e1 tr\u00ecnh ph\u1ea3n kh\u00e1ng c\u1ee7a n\u00f3 (antagonistic) \u0111\u1ed3ng ti\u1ebfn h\u00f3a v\u1edbi\u00a0<strong>ToMV<\/strong>. C\u00e1c t\u00e1c gi\u1ea3 \u0111\u00e3 ghi nh\u1eadn nh\u1eefng c\u1ea5u tr\u00fac c\u00f3 d\u1ea1ng tinh th\u1ec3 (crystal) \u0111\u1ed1i v\u1edbi c\u00e1c domains c\u00f3 t\u00ednh ch\u1ea5t \u1ee9c ch\u1ebf \u1edf \u0111\u1ea7u N \u0111\u1ed1i v\u1edbi\u00a0<strong>Tm-1\u00a0<\/strong>v\u00e0 m\u1ed9t th\u1ec3 \u0111\u1ed9t bi\u1ebfn Tm-1 t\u1ef1 nhi\u00ean, c\u00f3<strong>I91<\/strong>\u00a0\u0111\u01b0\u1ee3c thay v\u00e0o b\u1edfi\u00a0<strong>T<\/strong>. \u0110i\u1ec1u \u1ea5y t\u1ea1o ra m\u1ed9t kh\u1ea3 n\u0103ng to l\u1edbn \u0111\u1ec3 \u1ee9c ch\u1ebf s\u1ef1 t\u1ef1 t\u00e1i b\u1ea3n c\u1ee7a\u00a0<strong>ToMV RNA<\/strong>\u00a0v\u00e0 c\u00e1c ph\u1ee9c protein c\u1ee7a ch\u00fang v\u1edbi\u00a0<strong>ToMV-Hel<\/strong>. M\u1ed7i ph\u1ee9c c\u00f3 m\u1ed9t\u00a0<strong>Tm-1 dimer<\/strong>\u00a0v\u00e0 hai\u00a0<strong>ToMV-Hel monomers<\/strong>\u00a0giao di\u1ec7n nhau gi\u1eefa c\u1ea7u n\u1ed1i\u00a0<strong>Tm-1<\/strong>\u00a0v\u00e0\u00a0<strong>ToMV-Hel<\/strong>\u00a0nh\u1edd ph\u00e2n t\u1eed\u00a0<strong>ATP<\/strong>. C\u00e1c ph\u1ea7n c\u00f2n l\u1ea1i c\u1ee7a\u00a0<strong>ToMV-Hel<\/strong>\u00a0v\u00e0\u00a0<strong>Tm-1<\/strong>\u00a0bao g\u1ed3m k\u1ebft qu\u1ea3 \u0111\u1ed3ng ti\u1ebfn h\u00f3a c\u00f3 t\u00ednh ch\u1ea5t \u0111\u1ed1i kh\u00e1ng (antagonistic coevolution) \u0111\u01b0\u1ee3c ng\u01b0\u1eddi ta t\u00ecm th\u1ea5y trong giao di\u1ec7n n\u00e0y. S\u1ef1 kh\u00e1c nhau v\u1ec1 c\u1ea5u tr\u00fac nh\u01b0 v\u1eady gi\u1eefa\u00a0<strong>ToMV-Hel<\/strong>\u00a0trong c\u1ea5u h\u00ecnh t\u1ef1 do c\u1ee7a n\u00f3 v\u00e0 trong ph\u1ee9c c\u00f3<strong>\u00a0Tm-1<\/strong>\u00a0cho th\u1ea5y r\u1eb1ng\u00a0<strong>Tm-1<\/strong>\u00a0\u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ho\u1ea1t t\u00ednh c\u1ee7a men\u00a0<strong>nucleoside triphosphatase<\/strong>\u00a0\u0111\u1ed1i v\u1edbi\u00a0<strong>ToMV-Hel<\/strong>. \u1ea2nh h\u01b0\u1edfng n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c ng\u01b0\u1eddi ta x\u00e1c \u0111\u1ecbnh trong th\u00ed nghi\u1ec7m. C\u00e1c m\u00f4 ph\u1ecfng \u0111\u1ed9ng th\u00e1i h\u1ecdc \u1edf m\u1ee9c \u0111\u1ed9 ph\u00e2n t\u1eed c\u1ee7a c\u00e1c ph\u1ee9c \u0111u\u1ed9c h\u00ecnh th\u00e0nh b\u1edfi<strong>\u00a0Tm-1\u00a0<\/strong>v\u1edbi th\u1ec3 \u0111\u1ed9t bi\u1ebfn c\u1ee7a\u00a0<strong>ToMV-Hel<\/strong>\u00a0cho th\u1ea5y: l\u00e0m th\u1ebf n\u00e0o amino acid thay \u0111\u1ed5i \u0111\u01b0\u1ee3c\u00a0<strong>ToMV-Hel<\/strong>\u00a0\u0111\u1ec3 l\u00e0m t\u1ed5n h\u1ea1i \u0111\u1ebfn s\u1ef1 t\u01b0\u01a1ng t\u00e1c v\u1edbi\u00a0<strong>Tm-1,<\/strong>\u00a0nh\u1eb1m ph\u00e1 h\u1ecfng t\u00ednh kh\u00e1ng b\u1ec7nh. Theo k\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u, c\u00f9ng v\u1edbi \u0111\u1eb7c \u0111i\u1ec3m sinh h\u00f3a c\u1ee7a t\u01b0\u01a1ng t\u00e1c gi\u1eefa\u00a0<strong>ToMV-Hel<\/strong>\u00a0v\u00e0 \u0111\u1ed9t bi\u1ebfn\u00a0<strong>Tm-1,<\/strong>\u1ea3nh h\u01b0\u1edfng c\u1ee7a \u0111\u1ed9t bi\u1ebfn trong c\u00e1c g\u1ed1c c\u00f3 t\u00ednh ch\u1ea5t \u0111a h\u00ecnh (polymorphic residues) c\u1ee7a\u00a0<strong>Tm-1<\/strong>, ng\u01b0\u1eddi ta cho r\u1eb1ng c\u00f3 m\u1ed9t s\u1ef1 ki\u1ec7n \u1edf m\u1ee9c \u0111\u1ed9 nguy\u00ean t\u1eed (atomic view) v\u1edbi c\u00e1i g\u1ecdi l\u00e0 \u201c<strong>step-by-step coevolutionary arms race<\/strong>\u201d \u0111\u00e3 x\u1ea3y ra gi\u1eefa protein qui \u0111\u1ecbnh t\u00ednh kh\u00e1ng b\u1ec7nh c\u1ee7a c\u00e2y c\u00e0 chua v\u1edbi nh\u1eefng bi\u1ec3u hi\u1ec7n m\u1edbi c\u1ee7a proein virus g\u00e2y b\u1ec7nh.<\/p>\n<p>&nbsp;<\/p>\n<p>Xem\u00a0<a title=\"Tu\u1ea7n tin khoa h\u1ecdc 394 (25 - 31\/08\/2014)\" href=\"http:\/\/www.pnas.org\/content\/111\/33\/E3486.abstract.html?etoc\">http:\/\/www.pnas.org\/content\/111\/33\/E3486.abstract.html?etoc<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Kazuhiro\u00a0Ishibashi v\u00e0 ctv. (2014) \u0111\u00e3 c\u00f4ng b\u1ed1 k\u1ebf qu\u1ea3 c\u00f4ng tr\u00ecnh n\u00e0y tr\u00ean t\u1ea1p ch\u00ed PNAS, August 19, 2014; Vol.111; No.33 E3486-E3495. Gi\u1ea3 thuy\u1ebft Red Queen cho r\u1eb1ng c\u00e1c gen c\u00f3 ch\u1ee9c n\u0103ng trong ph\u1ea3n \u1ee9ng t\u1ef1 v\u1ec7 c\u1ee7a c\u00e2y ch\u1ee7 \u0111\u00e3 ti\u1ebfn h\u00f3a \u0111\u1ec3 ch\u1ed1ng l\u1ea1i c\u00e1c \u1ea3nh h\u01b0\u1edfng b\u1ea5t l\u1ee3i c\u1ee7a virus g\u00e2y [&#8230;]\n","protected":false},"author":1,"featured_media":1714,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[87],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/1698"}],"collection":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/comments?post=1698"}],"version-history":[{"count":0,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/1698\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media\/1714"}],"wp:attachment":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media?parent=1698"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/categories?post=1698"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/tags?post=1698"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}