{"id":2027,"date":"2013-06-03T02:54:43","date_gmt":"2013-06-02T19:54:43","guid":{"rendered":"http:\/\/antoansinhhoc.vn\/?p=2027"},"modified":"2013-06-03T02:54:43","modified_gmt":"2013-06-02T19:54:43","slug":"ban-do-gen-3d-cua-ruoi-giam-drosophila","status":"publish","type":"post","link":"https:\/\/nbca.gov.vn\/ban-do-gen-3d-cua-ruoi-giam-drosophila\/","title":{"rendered":"B\u1ea3n \u0111\u1ed3 gen 3D c\u1ee7a ru\u1ed3i gi\u1ea5m Drosophila"},"content":{"rendered":"
\n

Sinh h\u1ecdc ph\u00e2n t\u1eed: C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 c\u00f3 nh\u1eefng hi\u1ec3u bi\u1ebft s\u00e2u h\u01a1n v\u1ec1 c\u00e1c y\u1ebfu t\u1ed1 quy\u1ebft \u0111\u1ecbnh s\u1ef1 bi\u1ec3u hi\u1ec7n gen b\u1eb1ng c\u00e1ch gi\u1ea3i m\u00e3 c\u1ea5u tr\u00fac gen 3D c\u1ee7a ru\u1ed3i gi\u1ea5m Drosophila.<\/p>\n

\u0110\u0103ng ng\u00e0y\u00a003-06-2013\u00a0trong chuy\u00ean m\u1ee5c\u00a0Tin th\u1ebf gi\u1edbi<\/a><\/p>\n

Trong khi t\u1ea5t c\u1ea3 c\u00e1c t\u1ebf b\u00e0o c\u1ee7a m\u1ed9t sinh v\u1eadt x\u00e1c \u0111\u1ecbnh c\u00f3 b\u1ed9 gen gi\u1ed1ng nhau, th\u00ec c\u00e1c ki\u1ec3u bi\u1ec3u hi\u1ec7n gen kh\u00e1c nhau h\u00ecnh th\u00e0nh protein l\u1ea1i quy\u1ebft \u0111\u1ecbnh \u0111\u1eb7c \u0111i\u1ec3m ch\u00ednh c\u1ee7a c\u00e1c ki\u1ec3u h\u00ecnh t\u1ebf b\u00e0o, v\u00ed d\u1ee5 nh\u01b0 ch\u1ee9c n\u0103ng ho\u1ea1t \u0111\u1ed9ng hay t\u1eadp t\u00ednh c\u1ee7a t\u1ebf b\u00e0o. V\u00ec v\u1eady tr\u00ecnh t\u1ef1 to\u00e0n b\u1ed9 b\u1ed9 gen kh\u00f4ng \u0111\u1ee7 \u0111\u1ec3 gi\u1ea3i th\u00edch v\u1ec1 t\u00ednh \u0111\u1ed3ng nh\u1ea5t t\u1ebf b\u00e0o, v\u00e0 ng\u00e0y c\u00e0ng c\u00f3 nhi\u1ec1u b\u1eb1ng ch\u1ee9ng ch\u1ec9 ra r\u1eb1ng c\u1ea5u tr\u00fac 3D c\u1ee7a b\u1ed9 gen c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn s\u1ef1 bi\u1ec3u hi\u1ec7n gen.<\/p>\n

H\u1ea7u h\u1ebft b\u1eb1ng ch\u1ee9ng t\u1eeb nh\u1eefng quan s\u00e1t b\u1eb1ng k\u00ednh hi\u1ec3n vi \u0111\u1ec1u ch\u1ec9 ra r\u1eb1ng nh\u1eefng gen \u0111\u01b0\u1ee3c ho\u1ea1t h\u00f3a c\u00f3 v\u1ecb tr\u00ed x\u00e1c \u0111\u1ecbnh trong nh\u00e2n t\u1ebf b\u00e0o. Nh\u00e0 nghi\u00ean c\u1ee9u Giacomo Cavalli \u0111\u1ebfn t\u1eeb IGH2<\/sup>\u00a0\u1edf Montpellier, th\u00e0nh vi\u00ean trong nh\u00f3m nghi\u00ean c\u1ee9u h\u1ee3p t\u00e1c v\u1edbi Vi\u1ec7n Khoa h\u1ecdc Weizmann \u1edf Israel cho bi\u1ebft:\u00a0\u201cNghi\u00ean c<\/em>\u1ee9<\/em>u m<\/em>\u1edb<\/em>i1<\/sup>\u00a0c<\/em>\u1ee7<\/em>a ch<\/em>\u00fa<\/em>ng t<\/em>\u00f4<\/em>i <\/em>\u0111<\/em>\u01b0<\/em>a ra b<\/em>\u1ea3<\/em>n <\/em>\u0111<\/em>\u1ed3<\/em> 3D c<\/em>\u00f3<\/em> \u0111<\/em>\u1ed9<\/em> ph<\/em>\u00e2<\/em>n gi<\/em>\u1ea3<\/em>i cao v<\/em>\u1ec1<\/em> c<\/em>\u1ea5<\/em>u tr<\/em>\u00fa<\/em>c kh<\/em>\u00f4<\/em>ng gian c<\/em>\u1ee7<\/em>a b<\/em>\u1ed9<\/em> gen, gi<\/em>\u1ea3<\/em>i th<\/em>\u00ed<\/em>ch chi ti<\/em>\u1ebf<\/em>t l<\/em>\u00e0<\/em>m th<\/em>\u1ebf<\/em> n<\/em>\u00e0<\/em>o gen <\/em>\u0111<\/em>\u01b0\u1ee3<\/em>c <\/em>\u0111<\/em>\u1ecb<\/em>nh v<\/em>\u1ecb<\/em> kh<\/em>\u00f4<\/em>ng gian c<\/em>\u00f3<\/em> li<\/em>\u00ea<\/em>n quan t<\/em>\u1edb<\/em>i t<\/em>\u00ec<\/em>nh tr<\/em>\u1ea1<\/em>ng ho<\/em>\u1ea1<\/em>t h<\/em>\u00f3<\/em>a c<\/em>\u1ee7<\/em>a ch<\/em>\u00fa<\/em>ng<\/em>\u201d<\/em>.<\/p>\n

 <\/p>\n<\/div>\n

\n\n\n\n\n
\"\"<\/td>\n<\/tr>\n
M\u00f4 t\u1ea3 b\u1ea3n \u0111\u1ed3 gen 3D c\u1ee7a 15 tri\u1ec7u c\u1eb7p v\u00f9ng c\u01a1 s\u1edf c\u1ee7a nhi\u1ec5m s\u1eafc th\u1ec3 2R. C\u00e1c v\u00f2ng tr\u00f2n ch\u1ec9 v\u00f9ng c\u00f3 c\u00e1c li\u00ean l\u1ea1c m\u1ea1nh m\u1ebd v\u1edbi t\u1ebf b\u00e0o d\u00f9 r\u1ea5t xa nhi\u1ec5m s\u1eafc th\u1ec3 tuy\u1ebfn t\u00ednh.<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

B\u1ea3n \u0111\u1ed3 3D cho th\u1ea5y r\u1eb1ng b\u1ed9 gen c\u1ee7a ru\u1ed3i gi\u1ea5m Drosophila \u0111\u01b0\u1ee3c s\u1eafp x\u1ebfp th\u00e0nh nh\u1eefng v\u00f9ng c\u1ea5u tr\u00fac t\u1eadp h\u1ee3p v\u00e0i ki\u1ec3u gen, m\u00e0 c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c t\u00e1ch ra b\u1edfi h\u00e0ng tri\u1ec7u c\u00e1c nucleotit trong tr\u00ecnh t\u1ef1 tuy\u1ebfn t\u00ednh c\u1ee7a b\u1ed9 gen. Th\u00fa v\u1ecb h\u01a1n l\u00e0 t\u1ea5t c\u1ea3 gen trong c\u00f9ng m\u1ed9t v\u00f9ng \u0111\u1ec1u n\u1eb1m trong m\u1ed9t tr\u1ea1ng th\u00e1i k\u00edch ho\u1ea1t, c\u1ea3 bi\u1ec3u hi\u1ec7n hay kh\u00f4ng bi\u1ec3u hi\u1ec7n v\u00e0 c\u1ea5u tr\u00fac 3D c\u1ee7a ch\u00fang cho ph\u00e9p thi\u1ebft l\u1eadp nhi\u1ec1u m\u1ed1i li\u00ean l\u1ea1c gi\u1eefa ch\u00fang. \u0110i\u1ec1u \u0111\u00f3 cho th\u1ea5y r\u1eb1ng c\u1ea5u tr\u00fac trong v\u00f9ng h\u1ea1t nh\u00e2n l\u00e0 y\u1ebfu t\u1ed1 quy\u1ebft \u0111\u1ecbnh \u0111\u1ebfn s\u1ef1 quy \u0111\u1ecbnh bi\u1ec3u hi\u1ec7n gen.<\/p>\n

\u0110\u1ec3 c\u00f3 \u0111\u01b0\u1ee3c k\u1ebft qu\u1ea3 n\u00e0y, Cavalli v\u00e0 c\u00e1c c\u1ed9ng s\u1ef1 \u0111\u00e3 s\u1eed d\u1ee5ng m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n v\u00e0o n\u0103m 2009 b\u1edfi c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u M\u1ef9. Ph\u01b0\u01a1ng ph\u00e1p n\u00e0y bao g\u1ed3m ba b\u01b0\u1edbc ch\u00ednh: \u0111\u1ea7u ti\u00ean l\u00e0 s\u1eeda ch\u1eefa n\u1ed9i b\u1ed9 v\u00e0 t\u01b0\u01a1ng t\u00e1c gi\u1eefa c\u00e1c nhi\u1ec5m s\u1eafc th\u1ec3 v\u1edbi focman\u0111\u00eahit; ti\u1ebfp theo l\u00e0 g\u1eafn k\u1ebft c\u00e1c \u0111i\u1ec3m cu\u1ed1i c\u1ee7a hai v\u00f9ng li\u00ean l\u1ea1c b\u1eb1ng enzym DNA ligase c\u00f3 ngu\u1ed3n g\u1ed1c t\u1eeb vi khu\u1ea9n v\u00e0 cu\u1ed1i c\u00f9ng l\u00e0 x\u00e1c \u0111\u1ecbnh tr\u00ecnh t\u1ef1 c\u1ee7a hai v\u00f9ng li\u00ean l\u1ea1c n\u00e0y. Nh\u1eefng c\u1ea3i ti\u1ebfn m\u00e0 nh\u00f3m nghi\u00ean c\u1ee9u c\u1ee7a Cavalli t\u00ecm ra \u0111\u00e3 cho ph\u00e9p li\u00ean l\u1ea1c \u0111\u01b0\u1ee3c ph\u1ea3n \u00e1nh \u1edf m\u1ed9t quy m\u00f4 t\u1ed1t h\u01a1n, gi\u1ea3m m\u1ee9c \u0111\u1ed9 gen \u0111\u01a1n nh\u1ea5t. D\u1ef1a tr\u00ean h\u00e0ng tri\u1ec7u \u0111\u1ecba ch\u1ec9 li\u00ean l\u1ea1c, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 v\u1ebd th\u00e0nh c\u00f4ng b\u1ea3n \u0111\u1ed3 3D c\u00f3 \u0111\u1ed9 ph\u00e2n gi\u1ea3i cao c\u1ee7a c\u00e1c t\u01b0\u01a1ng t\u00e1c gen.<\/p>\n

Ch\u00fang ta c\u00f3 th\u1ec3 theo d\u00f5i nh\u1eefng thay \u0111\u1ed5i trong c\u1ea5u tr\u00fac c\u1ee7a nhi\u1ec5m s\u1eafc th\u1ec3, \u0111\u1eb7c bi\u1ec7t l\u00e0 nh\u1eefng thay \u0111\u1ed5i li\u00ean quan \u0111\u1ebfn s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a b\u1ec7nh ung th\u01b0 d\u1ef1a v\u00e0o b\u1ea3n \u0111\u1ed3 3D. \u201cL<\/em>\u1ead<\/em>p b<\/em>\u1ea3<\/em>n <\/em>\u0111<\/em>\u1ed3<\/em> nh<\/em>\u1eef<\/em>ng kh<\/em>\u00e1<\/em>c th<\/em>\u01b0\u1edd<\/em>ng trong nhi<\/em>\u1ec5<\/em>m s<\/em>\u1eaf<\/em>c th<\/em>\u1ec3<\/em> c<\/em>\u00f3<\/em> th<\/em>\u1ec3<\/em> gi<\/em>\u00fa<\/em>p d<\/em>\u1ef1<\/em> \u0111<\/em>o<\/em>\u00e1<\/em>n s<\/em>\u1ef1<\/em> ph<\/em>\u00e1<\/em>t tri<\/em>\u1ec3<\/em>n c<\/em>\u1ee7<\/em>a b<\/em>\u1ec7<\/em>nh t<\/em>\u1ead<\/em>t nh<\/em>\u01b0<\/em> b<\/em>\u1ec7<\/em>nh b<\/em>\u1ea1<\/em>ch c<\/em>\u1ea7<\/em>u<\/em>\u201d, Cavalli k\u1ebft lu\u1eadn.<\/p>\n

    \n
  1. t .Sexton, et al., \u201cthree-dimensional folding and functional organization principles of the Drosophila genome,\u201d Cell,\u00a0 2012. 148: 1-15.<\/em>
    \n02. Institut de g\u00e9n\u00e9tique humaine (CNRS).<\/em><\/li>\n<\/ol>\n

     <\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Sinh h\u1ecdc ph\u00e2n t\u1eed: C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 c\u00f3 nh\u1eefng hi\u1ec3u bi\u1ebft s\u00e2u h\u01a1n v\u1ec1 c\u00e1c y\u1ebfu t\u1ed1 quy\u1ebft \u0111\u1ecbnh s\u1ef1 bi\u1ec3u hi\u1ec7n gen b\u1eb1ng c\u00e1ch gi\u1ea3i m\u00e3 c\u1ea5u tr\u00fac gen 3D c\u1ee7a ru\u1ed3i gi\u1ea5m Drosophila. \u0110\u0103ng ng\u00e0y\u00a003-06-2013\u00a0trong chuy\u00ean m\u1ee5c\u00a0Tin th\u1ebf gi\u1edbi Trong khi t\u1ea5t c\u1ea3 c\u00e1c t\u1ebf b\u00e0o c\u1ee7a m\u1ed9t sinh v\u1eadt x\u00e1c […]\n","protected":false},"author":1,"featured_media":6429,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[87],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/2027"}],"collection":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/comments?post=2027"}],"version-history":[{"count":0,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/2027\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media\/6429"}],"wp:attachment":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media?parent=2027"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/categories?post=2027"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/tags?post=2027"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}