{"id":6610,"date":"2013-05-02T03:05:29","date_gmt":"2013-05-01T20:05:29","guid":{"rendered":"http:\/\/antoansinhhoc.vn\/?p=2068"},"modified":"2013-05-02T03:05:29","modified_gmt":"2013-05-01T20:05:29","slug":"fda-gia-han-thoi-gian-lay-y-kien-cho-ca-hoi-bien-doi-gen","status":"publish","type":"post","link":"https:\/\/nbca.gov.vn\/fda-gia-han-thoi-gian-lay-y-kien-cho-ca-hoi-bien-doi-gen\/","title":{"rendered":"FDA gia h\u1ea1n th\u1eddi gian l\u1ea5y \u00fd ki\u1ebfn cho c\u00e1 h\u1ed3i bi\u1ebfn \u0111\u1ed5i gen"},"content":{"rendered":"
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H\u00e0ng ng\u00e0n nh\u00e0 nghi\u00ean c\u1ee9u tr\u00ean to\u00e0n th\u1ebf gi\u1edbi l\u00e0m vi\u1ec7c 8 n\u0103m li\u00ean t\u1ee5c, ti\u00eau t\u1ed1n h\u01a1n 1 t\u1ef7 USD, v\u00e0 cu\u1ed1i c\u00f9ng ng\u00e0y 14\/4\/2003, h\u1ecd th\u00f4ng b\u00e1o \u0111\u00e3 ho\u00e0n th\u00e0nh nhi\u1ec7m v\u1ee5 gi\u1ea3i m\u00e3 b\u1ed9 gene ng\u01b0\u1eddi (Human Genome), l\u1eadp ra danh s\u00e1ch ba t\u1ef7 k\u00fd t\u1ef1 c\u1ee7a m\u00e3 di truy\u1ec1n t\u1ea1o n\u00ean nh\u1eefng DNA c\u1ee7a con ng\u01b0\u1eddi.<\/p>\n

\u0110\u1ec3 k\u1ef7 ni\u1ec7m 10 n\u0103m s\u1ef1 ki\u1ec7n n\u00e0y, xin t\u00f3m l\u01b0\u1ee3c nh\u1eefng \u00fd ki\u1ebfn c\u1ee7a Eric D. Green, Vi\u1ec7n tr\u01b0\u1edfng Vi\u1ec7n nghi\u00ean c\u1ee9u qu\u1ed1c gia v\u1ec1 gene ng\u01b0\u1eddi (NHGRI), M\u1ef9, v\u1ec1 nh\u1eefng g\u00ec \u0111\u00e3 \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n, \u00fd ngh\u0129a c\u1ee7a n\u00f3 v\u00e0 nh\u1eefng g\u00ec ch\u1edd \u0111\u1ee3i s\u1eafp t\u1edbi.<\/p>\n

\u0110\u0103ng ng\u00e0y\u00a002-05-2013\u00a0trong chuy\u00ean m\u1ee5c\u00a0Tin th\u1ebf gi\u1edbi<\/a><\/p>\n

Xin h\u00e3y tr\u1edf l\u1ea1i ng\u00e0y n\u00e0y c\u00e1ch \u0111\u00e2y 10 n\u0103m. Gene c\u1ee7a nh\u1eefng ai \u0111\u00e3 \u0111\u01b0\u1ee3c gi\u1ea3i m\u00e3? V\u00e0 t\u1ea1i sao ng\u01b0\u1eddi ta mu\u1ed1n bi\u1ebft tr\u00ecnh t\u1ef1 b\u1ed9 gene c\u1ee7a m\u1ed9t s\u1ed1 ng\u01b0\u1eddi ch\u1ecdn l\u1ef1a m\u1ed9t c\u00e1ch ng\u1eabu nhi\u00ean? Ph\u1ea3i ch\u0103ng t\u1ea5t c\u1ea3 ch\u00fang ta \u0111\u1ec1u gi\u1ed1ng nhau?<\/em><\/p>\n

\u00dd t\u01b0\u1edfng xuy\u00ean su\u1ed1t c\u1ea3 qu\u00e1 tr\u00ecnh kh\u00f4ng ph\u1ea3i l\u00e0 gi\u1ea3i m\u00e3 s\u1eafp x\u1ebfp gene c\u1ee7a m\u1ed9t con ng\u01b0\u1eddi c\u1ee5 th\u1ec3 n\u00e0o m\u00e0 l\u00e0 \u0111\u1ec3 t\u1ea1o l\u1eadp m\u1ed9t ngu\u1ed3n t\u00e0i nguy\u00ean. \u0110\u00f3 l\u00e0 tr\u00ecnh t\u1ef1 s\u1eafp x\u1ebfp m\u1ed9t b\u1ed9 gene gi\u1ea3 thi\u1ebft, m\u1ed9t b\u1ed9 gene m\u1eabu chu\u1ea9n (reference). N\u00f3 mang \u00fd ngh\u0129a b\u1ed9 gene \u0111\u1ea1i di\u1ec7n cho nh\u00e2n lo\u1ea1i.<\/p>\n

Th\u1ebf ngh\u0129a l\u00e0 sao? C\u00e1c \u00f4ng \u0111\u00e3 \u0111\u00e3 s\u1eed d\u1ee5ng DNA c\u1ee7a con ng\u01b0\u1eddi, ph\u1ea3i kh\u00f4ng? T\u1ea1i sao l\u1ea1i n\u00f3i \u0111\u00f3 l\u00e0 b\u1ed9 gene gi\u1ea3 thi\u1ebft?<\/em><\/p>\n

L\u00fac \u0111\u00f3 c\u00e1ch gi\u1ea3i m\u00e3 tr\u00ecnh t\u1ef1 gene \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n nh\u01b0 sau. T\u1ea1i m\u1ed7i m\u1ed9t th\u1eddi \u0111i\u1ec3m, ch\u00fang t\u00f4i l\u1ea7n l\u01b0\u1ee3t \u0111\u1ecdc c\u00e1c k\u00fd t\u1ef1 c\u1ee7a b\u1ed9 gene, m\u1ed7i l\u1ea7n m\u1ed9t trang t\u1ea1i m\u1ed9t th\u1eddi \u0111i\u1ec3m, v\u00e0 \u1edf cu\u1ed1i ng\u00e0y th\u00ec t\u1edbi l\u01b0\u1ee3t c\u00e1c trang ti\u1ebfp kh\u00e1c c\u1ee7a nh\u1eefng ng\u01b0\u1eddi kh\u00e1c nhau. M\u1ed7i trang l\u00e0 m\u1ed9t \u0111o\u1ea1n DNA, bao g\u1ed3m kho\u1ea3ng 100 ngh\u00ecn g\u1ed1c c\u01a1 b\u1ea3n (base) trong t\u1ed5ng c\u1ed9ng ba t\u1ef7 g\u1ed1c c\u01a1 b\u1ea3n (t\u1ee9c l\u00e0 b\u1ed1n h\u00f3a ch\u1ea5t t\u1ea1o n\u00ean DNA). B\u1ed9 gene c\u1ee7a m\u1ed9t ng\u01b0\u1eddi hi\u1ebfn m\u00e1u v\u00f4 danh \u1edf Buffalo chi\u1ebfm ph\u1ea7n l\u1edbn, b\u1edfi v\u00ec ch\u00e0ng ta l\u00e0 chuy\u00ean gia trong vi\u1ec7c t\u1ea1o ra m\u1ed9t th\u01b0 vi\u1ec7n l\u1edbn v\u1ec1 DNA – t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi c\u00e1c trang – \u0111ang l\u00e0m vi\u1ec7c t\u1ea1i Vi\u1ec7n Ung th\u01b0 Roswell Park, \u1edf Buffalo.<\/p>\n

Nh\u01b0ng n\u1ebfu \u0111\u00f3 ch\u1ec9 l\u00e0 m\u1ed9t gene gi\u1ea3 thi\u1ebft, \u0111\u01b0\u1ee3c t\u1ea1o th\u00e0nh t\u1eeb c\u00e1c m\u1ea3nh (bits) v\u00e0 mi\u1ebfng (pieces) c\u1ee7a chu\u1ed7i DNA t\u1eeb nhi\u1ec1u ng\u01b0\u1eddi kh\u00e1c nhau, th\u00ec sao l\u1ea1i t\u1ed1t h\u01a1n m\u1ed9t gene th\u1eadt \u0111\u01b0\u1ee3c?<\/em><\/p>\n

\u0110\u00f3 l\u00e0 m\u1ed9t b\u1ed9 chu\u1ea9n \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 l\u00e0m c\u00e1c nghi\u00ean c\u1ee9u kh\u00e1c. Hai ng\u01b0\u1eddi kh\u00e1c nhau th\u00ec c\u1ee9 1.000 g\u1ed1c c\u01a1 b\u1ea3n m\u1edbi c\u00f3 m\u1ed9t g\u1ed1c c\u01a1 b\u1ea3n kh\u00e1c nhau th\u00f4i, th\u1ebf ngh\u0129a l\u00e0 99,9% b\u1ed9 gene c\u1ee7a b\u1ea5t k\u1ef3 ng\u01b0\u1eddi n\u00e0o c\u0169ng gi\u1ed1ng nh\u01b0 nhau. Ch\u00fang t\u00f4i s\u1eed d\u1ee5ng c\u00f4ng c\u1ee5 \u0111\u00f3 \u0111\u1ec3 x\u00e2y d\u1ef1ng ki\u1ec3u nh\u01b0 v\u1ebd m\u1ed9t b\u1ea3n \u0111\u1ed3 \u0111\u01b0\u1eddng cao t\u1ed1c. Ch\u00fang ta c\u00f3 th\u1ec3 \u0111i theo b\u1ea3n \u0111\u1ed3 \u0111\u00f3 v\u00e0 b\u1ed5 sung nh\u1eefng th\u00f4ng tin n\u00e0o l\u00e0 quan tr\u1ecdng cho m\u1ed7i con \u0111\u01b0\u1eddng. So s\u00e1nh d\u1ec5 hi\u1ec3u nh\u1ea5t l\u00e0 gi\u1ed1ng nh\u01b0 khi b\u1ea1n s\u1eed d\u1ee5ng b\u1ea3n \u0111\u1ed3 GPS trong xe h\u01a1i. Th\u1eadt tuy\u1ec7t l\u00e0 b\u1ea1n c\u00f3 m\u1ed9t b\u1ea3n \u0111\u1ed3 \u0111\u01b0\u1eddng cao t\u1ed1c, nh\u01b0ng b\u1ea1n th\u1ef1c s\u1ef1 c\u00f2n mu\u1ed1n bi\u1ebft \u0111\u00e2u l\u00e0 trung t\u00e2m mua s\u1eafm, \u0111\u00e2u l\u00e0 tr\u1ea1m x\u0103ng, n\u01a1i \u0111\u1ed7 xe s\u1eafp t\u1edbi, qu\u00e1n c\u01a1m… Ch\u00fang t\u00f4i mu\u1ed1n bi\u1ebft \u0111\u00e2u l\u00e0 c\u00e1c gene, l\u00e0 b\u1ed9 ph\u1eadn c\u1ee7a b\u1ed9 gene ch\u1ecbu tr\u00e1ch nhi\u1ec7m m\u00e3 h\u00f3a protein. \u0110\u00e2u l\u00e0 nh\u1eefng n\u01a1i tr\u00ean b\u1ed9 gene l\u00e0m cho ng\u01b0\u1eddi n\u00e0y kh\u00e1c ng\u01b0\u1eddi kia? \u0110\u00e2u l\u00e0 nh\u1eefng gene m\u00e3 h\u00f3a cho c\u00e1c b\u1ec7nh t\u1eadt?
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\n<\/em>Hi\u1ec7n nay \u0111\u1ec3 gi\u1ea3i tr\u00ecnh t\u1ef1 b\u1ed9 gene c\u1ee7a m\u1ed9t ng\u01b0\u1eddi c\u00f3 kh\u00f3 l\u1eafm kh\u00f4ng?<\/em><\/p>\n

Ch\u00fang ta hi\u1ec7n nay c\u00f3 th\u1ec3 gi\u1ea3i tr\u00ecnh t\u1ef1 h\u1ec7 gene ng\u01b0\u1eddi nh\u01b0 tr\u01b0\u1edbc \u0111\u00e2y ch\u1ec9 trong m\u1ed9t v\u00e0i ng\u00e0y v\u00e0 v\u1edbi gi\u00e1 d\u01b0\u1edbi 10 ngh\u00ecn USD, c\u00f3 th\u1ec3 ch\u1ec9 b\u1ed1n hay n\u0103m ngh\u00ecn USD th\u00f4i. V\u00e0 ch\u00fang t\u00f4i gi\u1ea3i tr\u00ecnh t\u1ef1 h\u1ec7 gene cho b\u1ea1n g\u1ed3m m\u1ed9t b\u1ea3n nh\u1eadn \u0111\u01b0\u1ee3c t\u1eeb cha v\u00e0 m\u1ed9t b\u1ea3n tr\u00ecnh t\u1ef1 gene m\u00e0 b\u1ea1n nh\u1eadn \u0111\u01b0\u1ee3c t\u1eeb m\u1eb9 c\u1ee7a b\u1ea1n, t\u1ed5ng c\u1ed9ng s\u00e1u t\u1ef7 c\u1eb7p \u0111\u1ea5y, m\u00e0 chi ph\u00ed ch\u1ec9 t\u01b0\u01a1ng \u0111\u01b0\u01a1ng nh\u01b0 ch\u1ee5p c\u1ed9ng h\u01b0\u1edfng t\u1eeb (MRI). Xin nh\u1edb r\u1eb1ng ch\u01b0\u01a1ng tr\u00ecnh gi\u1ea3i m\u00e3 b\u1ed9 gene ng\u01b0\u1eddi ng\u00e0y tr\u01b0\u1edbc ch\u1ec9 gi\u1ea3i c\u00f3 3 t\u1ef7 g\u1ed1c c\u01a1 b\u1ea3n th\u00f4i nh\u00e9!
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\n<\/em>L\u00e0m th\u1ebf n\u00e0o m\u00e0 l\u1ea1i c\u00f3 \u0111\u01b0\u1ee3c gi\u00e1 r\u1ebb nh\u01b0 v\u1eady?<\/em><\/p>\n

Th\u00e1ng 4\/2003, ngay sau khi ho\u00e0n th\u00e0nh b\u1ed9 gene ng\u01b0\u1eddi, Vi\u1ec7n c\u1ee7a ch\u00fang t\u00f4i k\u00eau g\u1ecdi t\u00ecm c\u00f4ng ngh\u1ec7 \u0111\u1ec3 cung c\u1ea5p m\u1ed9t b\u1ea3n tr\u00ecnh t\u1ef1 b\u1ed9 gene c\u1ee7a m\u1ed9t ng\u01b0\u1eddi v\u1edbi gi\u00e1 1.000 USD. Vi\u1ec7c \u0111\u00f3 \u0111\u00e3 g\u00e2y n\u00ean cu\u1ed9c tranh c\u00e3i gh\u00ea g\u1edbm. T\u00f4i c\u00f2n nh\u1edb m\u00ecnh \u0111\u00e3 mong m\u1ecfi nh\u01b0 th\u1ebf n\u00e0o \u0111\u1ec3 m\u1ed9t ng\u00e0y n\u00e0o \u0111\u00f3 ch\u00fang t\u00f4i s\u1ebd th\u1ef1c hi\u1ec7n \u0111\u01b0\u1ee3c tr\u00ecnh t\u1ef1 m\u1ed9t b\u1ed9 gene v\u1edbi ch\u1ec9 1.000 USD. Gi\u1edd th\u00ec t\u00f4i ch\u1eb3ng c\u1ea7n lo l\u1eafng v\u1ec1 c\u00e1i gi\u00e1 1.000 USD n\u1eefa. Ch\u00fang t\u00f4i \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c ti\u1ebfn b\u1ed9 \u0111\u1ebfn 6 b\u1eadc (t\u1ee9c 1 tri\u1ec7u l\u1ea7n) trong m\u1ed9t th\u1eadp k\u1ef7.<\/p>\n

\u00d4ng ngh\u0129 sao \u0111\u1ed1i v\u1edbi c\u00e2u h\u1ecfi c\u1ee7a nh\u1eefng ng\u01b0\u1eddi lu\u00f4n ho\u00e0i nghi: \u201c\u0110\u00e2u l\u00e0 nh\u1eefng ph\u01b0\u01a1ng ph\u00e1p ch\u1eefa tr\u1ecb cho c\u00e1c b\u1ec7nh m\u00e0 c\u00e1c \u00f4ng \u0111\u00e3 h\u1ee9a h\u1eb9n cho ch\u00fang t\u00f4i?\u201d<\/em><\/p>\n

T\u00f4i tr\u1edf th\u00e0nh Vi\u1ec7n tr\u01b0\u1edfng c\u1ee7a vi\u1ec7n nghi\u00ean c\u1ee9u n\u00e0y ba n\u0103m r\u01b0\u1ee1i tr\u01b0\u1edbc \u0111\u00e2y, v\u00e0 t\u00f4i c\u00f2n nh\u1edb nh\u01b0 in khi l\u1ea7n \u0111\u1ea7u ti\u00ean t\u00f4i g\u1eb7p g\u1ee1 v\u00e0 tr\u00f2 chuy\u1ec7n v\u1edbi m\u1ecdi ng\u01b0\u1eddi. Th\u01b0\u1eddng xuy\u00ean t\u00f4i nghe:<\/p>\n

\u201cC\u00e1c \u00f4ng \u0111\u00e3 ho\u00e0n th\u00e0nh c\u00f4ng vi<\/em>\u1ec7<\/em>c n<\/em>\u00e0<\/em>y h<\/em>\u01a1<\/em>n b<\/em>\u1ea3<\/em>y n<\/em>\u0103<\/em>m r<\/em>\u1ed3<\/em>i. M<\/em>\u00e0<\/em> \u0111\u00e3<\/em> th<\/em>\u1eaf<\/em>ng l<\/em>\u1ee3<\/em>i ch<\/em>\u01b0<\/em>a <\/em>\u0111<\/em>\u1ea5<\/em>y? <\/em>\u0110\u00e2<\/em>u l<\/em>\u00e0<\/em> nh<\/em>\u1eef<\/em>ng th<\/em>\u00e0<\/em>nh c<\/em>\u00f4<\/em>ng?<\/em>\u201d<\/em><\/p>\n

Gi\u1edd th\u00ec t\u00f4i kh\u00f4ng c\u00f2n nghe nh\u01b0 th\u1ebf nhi\u1ec1u n\u1eefa. T\u00f4i ngh\u0129 r\u1eb1ng nh\u1eefng g\u00ec \u0111ang x\u1ea3y ra, v\u00e0 \u0111\u00e3 x\u1ea3y ra trong ba n\u0103m qua l\u00e0 ch\u1ec9 s\u1ed1 t\u1ed5ng h\u1ee3p tuy\u1ec7t \u0111\u1ed1i c\u1ee7a th\u00e0nh c\u00f4ng. Ti\u1ebfng tr\u1ed1ng th\u00e0nh c\u00f4ng cu\u1ed1i c\u00f9ng \u0111\u00e3 \u00e1t \u0111\u01b0\u1ee3c t\u1ea5t c\u1ea3.<\/p>\n

Ch\u00fang t\u00f4i \u0111ang hi\u1ec3u bi\u1ebft th\u00eam b\u1ec7nh ung th\u01b0 v\u00e0 c\u00e1c b\u1ec7nh di truy\u1ec1n hi\u1ebfm g\u1eb7p. C\u00f3 nh\u1eefng c\u00e2u chuy\u1ec7n kh\u00f4ng th\u1ec3 tin \u0111\u01b0\u1ee3c nh\u01b0 gi\u1edd \u0111\u00e2y ch\u00fang t\u00f4i c\u00f3 th\u1ec3 ch\u1ec9 l\u1ea5y m\u00e1u t\u1eeb m\u1ed9t thai ph\u1ee5 m\u00e0 ph\u00e2n t\u00edch \u0111\u01b0\u1ee3c DNA c\u1ee7a thai nhi.<\/p>\n

H\u01a1n n\u1eefa ch\u00fang ta ng\u00e0y c\u00e0ng c\u00f3 nhi\u1ec1u \u0111\u01b0\u1eddng th\u00f4ng tin h\u01a1n \u0111\u1ec3 k\u00ea \u0111\u01a1n ch\u1eefa b\u1ec7nh b\u1edfi v\u00ec tr\u01b0\u1edbc ti\u00ean ch\u00fang ta c\u00f3 th\u1ec3 l\u00e0m x\u00e9t nghi\u1ec7m di truy\u1ec1n. Ch\u00fang ta c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng DNA c\u1ee7a vi sinh v\u1eadt \u0111\u1ec3 theo d\u00f5i s\u1ef1 b\u00f9ng ph\u00e1t c\u1ee7a d\u1ecbch b\u1ec7nh trong m\u1ed9t v\u00e0i gi\u1edd.<\/p>\n

Cu\u1ed9c ch\u01a1i \u0111\u00e3 thay \u0111\u1ed5i r\u1ed3i. \u0110\u00f3 l\u00e0 c\u00e1c th\u00e0nh t\u1ef1u to l\u1edbn \u0111\u00e3 \u0111\u1ea1t \u0111\u01b0\u1ee3c, v\u00e0 \u0111\u00f3 ch\u00ednh l\u00e0 c\u00e2u chuy\u1ec7n h\u1ee3p logic nh\u1ea5t \u0111\u1ec3 k\u1ec3 v\u1edbi m\u1ecdi ng\u01b0\u1eddi.<\/p>\n

XH<\/strong>\u00a0l\u01b0\u1ee3c thu\u1eadt\u00a0theo
\nhttp:\/\/www.nytimes.com\/2013\/04\/16\/science\/the-human-genome-project-then-and-now.html?ref=science
\nTheo\u00a0http:\/\/www.tiasang.com.vn<\/a><\/p>\n

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