{"id":6639,"date":"2014-03-18T01:18:08","date_gmt":"2014-03-17T18:18:08","guid":{"rendered":"http:\/\/antoansinhhoc.vn\/?p=1807"},"modified":"2014-03-18T01:18:08","modified_gmt":"2014-03-17T18:18:08","slug":"cac-nha-khoa-hoc-bao-cao-ve-mot-buoc-dai-nhay-vot-trong-viec-hieu-biet-cach-thuc-enzyme-pp1-tuong-tac-voi-cac-protein-khac","status":"publish","type":"post","link":"https:\/\/nbca.gov.vn\/cac-nha-khoa-hoc-bao-cao-ve-mot-buoc-dai-nhay-vot-trong-viec-hieu-biet-cach-thuc-enzyme-pp1-tuong-tac-voi-cac-protein-khac\/","title":{"rendered":"C\u00e1c nh\u00e0 khoa h\u1ecdc b\u00e1o c\u00e1o v\u1ec1 m\u1ed9t b\u01b0\u1edbc \u0111\u1ea1i nh\u1ea3y v\u1ecdt trong vi\u1ec7c hi\u1ec3u bi\u1ebft c\u00e1ch th\u1ee9c enzyme PP1 t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c protein kh\u00e1c"},"content":{"rendered":"
\n

Trong m\u1ed9t nghi\u00ean c\u1ee9u m\u1edbi \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Brown b\u00e1o c\u00e1o m\u1ed9t b\u01b0\u1edbc \u0111\u1ea1i nh\u1ea3y v\u1ecdt trong vi\u1ec7c hi\u1ec3u bi\u1ebft c\u00e1ch th\u1ee9c PP1 t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c protein kh\u00e1c \u0111\u1ec3 h\u00e0nh x\u1eed kh\u00e1c nhau trong c\u00e1c t\u00ecnh hu\u1ed1ng nh\u1ea5t \u0111\u1ecbnh.<\/span>\u0110\u0103ng ng\u00e0y 18-03-2014<\/span> trong chuy\u00ean m\u1ee5c Tin th\u1ebf gi\u1edbi<\/a><\/p>\n<\/div>\n

\n\n\n\n
\n\n\n\n
\"\"
\nEnzyme PP1, kh\u1ed1i m\u00e0u n\u00e2u v\u00e0ng \u1edf tr\u00ean, hi\u1ec7n di\u1ec7n \u1edf kh\u1eafp m\u1ecdi n\u01a1i trong c\u01a1 th\u1ec3 v\u00e0 \u0111\u00f3ng m\u1ed9t vai tr\u00f2 trong g\u1ea7n nh\u01b0 t\u1ea5t c\u1ea3 c\u00e1c qu\u00e1 tr\u00ecnh sinh h\u1ecdc. Vai tr\u00f2 \u0111\u00f3 h\u00ecnh th\u00e0nh h\u01a1n 200 protein \u0111i\u1ec1u h\u00f2a li\u00ean k\u1ebft v\u1edbi PP1, trong \u0111\u00f3 c\u00f3 m\u1ed9t lo\u1ea1i protein \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 PNUTS, m\u00e0u xanh v\u00e0 m\u00e0u h\u1ed3ng \u1edf tr\u00ean. \u1ea2nh: Ph\u00f2ng th\u00ed nghi\u1ec7n tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Brown.<\/em><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Trong K\u1ef7 y\u1ebfu c\u1ee7a Vi\u1ec7n h\u00e0n l\u00e2m Khoa h\u1ecdc Qu\u1ed1c gia Hoa K\u1ef3, m\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 khoa h\u1ecdc t\u1eeb Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Brown b\u00e1o c\u00e1o m\u1ed9t b\u01b0\u1edbc ti\u1ebfn quan tr\u1ecdng trong vi\u1ec7c x\u00e1c \u0111\u1ecbnh h\u00e0nh vi ri\u00eang bi\u1ec7t c\u1ee7a enzyme PP1 c\u00f3 m\u1eb7t \u1edf kh\u1eafp n\u01a1i li\u00ean quan \u0111\u1ebfn m\u1ed9t lo\u1ea1t b\u1ec7nh, bao g\u1ed3m c\u1ea3 b\u1ec7nh ung th\u01b0.<\/p>\n

 <\/p>\n

PP1, c\u00f3 vai tr\u00f2 chuy\u1ec3n c\u00e1c th\u00f4ng \u0111i\u1ec7p ph\u00e2n t\u1eed gi\u1eefa c\u00e1c t\u1ebf b\u00e0o, \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y kh\u00e1 nhi\u1ec1u \u1edf kh\u1eafp m\u1ecdi n\u01a1i trong c\u01a1 th\u1ec3. Ph\u1ea1m vi tr\u00e1ch nhi\u1ec7m r\u1ed9ng l\u1edbn c\u1ee7a n\u00f3 c\u00f3 ngh\u0129a l\u00e0 n\u00f3 l\u00e0 y\u1ebfu t\u1ed1 c\u1ed1t y\u1ebfu \u0111\u1ed1i v\u1edbi nhi\u1ec1u ch\u1ee9c n\u0103ng c\u00f3 l\u1ee3i cho s\u1ee9c kh\u1ecfe, v\u00e0 l\u00e0 nguy\u00ean nh\u00e2n g\u00e2y ra b\u1ec7nh khi sai h\u1ecfng x\u1ea3y ra. Nh\u01b0ng t\u00ednh r\u1ea5t kh\u00f4ng \u1ed5n \u0111\u1ecbnh c\u1ee7a n\u00f3 \u0111\u00e3 ng\u0103n n\u00f3 tr\u1edf th\u00e0nh m\u1ed9t m\u1ee5c ti\u00eau ph\u00e1t tri\u1ec3n d\u01b0\u1ee3c ph\u1ea9m, Rebecca Page, Ph\u00f3 Gi\u00e1o s\u01b0 sinh h\u1ecdc t\u1ea1i tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Brown v\u00e0 t\u00e1c gi\u1ea3 ch\u00ednh c\u1ee7a b\u00e0i b\u00e1o, cho bi\u1ebft.<\/p>\n

 <\/p>\n

\u201c\u0110i\u1ec1u tuy\u1ec7t v\u1eddi v\u1ec1 PP1 l\u00e0 kh\u00f4ng ai mu\u1ed1n s\u1eed d\u1ee5ng n\u00f3 cho m\u1ee5c ti\u00eau d\u01b0\u1ee3c ph\u1ea9m v\u00ec PP1 tham gia v\u00e0o h\u1ea7u h\u1ebft c\u00e1c qu\u00e1 tr\u00ecnh sinh h\u1ecdc,\u201d Page n\u00f3i. \u201cD\u01b0\u1eddng nh\u01b0 b\u1ea1n kh\u00f4ng th\u1ec3 ch\u1ec9 nh\u1eafm m\u1ee5c ti\u00eau v\u00e0o v\u1ecb tr\u00ed ho\u1ea1t h\u00f3a PP1, v\u00ed d\u1ee5 nh\u01b0 \u0111\u1ed1i v\u1edbi b\u1ec7nh ti\u1ec3u \u0111\u01b0\u1eddng, b\u1edfi v\u00ec sau \u0111\u00f3 b\u1ea1n s\u1ebd b\u1ecb t\u00e1c \u0111\u1ed9ng g\u00e2y nghi\u1ec7n, hay b\u1ec7nh Alzheimer v\u00e0 t\u1ea5t c\u1ea3 nh\u1eefng b\u1ec7nh kh\u00e1c c\u0169ng nh\u01b0 v\u1eady\u201d.<\/p>\n

N\u00f3i c\u00e1ch kh\u00e1c, \u0111i\u1ec1u ch\u1ebf ra m\u1ed9t lo\u1ea1i d\u01b0\u1ee3c ph\u1ea9m ng\u0103n ch\u1eb7n PP1 trong ph\u1ea1m vi c\u01a1 th\u1ec3 con ng\u01b0\u1eddi v\u00e0 b\u1ea1n s\u1ebd l\u00e0m h\u1ecfng n\u00f3 trong t\u1ea5t c\u1ea3 c\u00e1c ph\u1ea1m vi kh\u00e1c. Do \u0111\u00f3, c\u00e1c nh\u00e0 sinh h\u1ecdc c\u1ea5u tr\u00fac nh\u01b0 Page v\u00e0 \u0111\u1ed3ng t\u00e1c gi\u1ea3 Wolfgang Peti c\u1ee7a Tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Brown \u0111\u00e3 mong mu\u1ed1n t\u00ecm hi\u1ec3u nh\u1eefng g\u00ec l\u00e0m PP1 c\u01b0 x\u1eed theo nh\u1eefng c\u00e1ch ri\u00eang bi\u1ec7t trong c\u00e1c t\u00ecnh hu\u1ed1ng c\u1ee5 th\u1ec3.<\/p>\n

\u0110i\u1ec1u quan tr\u1ecdng l\u00e0 c\u00e1ch th\u1ee9c PP1 li\u00ean k\u1ebft v\u1edbi h\u01a1n 200 protein \u0111i\u1ec1u h\u00f2a kh\u00e1c nhau. C\u00e1c nh\u00e0 khoa h\u1ecdc bi\u1ebft r\u00f5 v\u1ec1 nh\u1eefng protein n\u00e0y v\u00e0 bi\u1ebft r\u00f5 v\u1ec1 c\u00e1c tr\u00ecnh t\u1ef1 axit amin t\u1ea1o n\u00ean ch\u00fang, nh\u01b0ng h\u1ecd kh\u00f4ng bi\u1ebft c\u1ea5u tr\u00fac c\u1ee7a ch\u00fang ho\u1eb7c tr\u00ean th\u1ef1c t\u1ebf ch\u00fang d\u1eabn d\u1eaft PP1 nh\u01b0 th\u1ebf n\u00e0o.<\/p>\n

\u201cKh\u1ea3 n\u0103ng d\u1ef1 \u0111o\u00e1n PP1 t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c protein r\u00e0ng bu\u1ed9c PP1 nh\u01b0 th\u1ebf n\u00e0o t\u1eeb m\u1ed9t tr\u00ecnh t\u1ef1 \u0111\u01a1n \u0111\u1ed9c v\u1eabn ch\u01b0a \u0111\u01b0\u1ee3c n\u1eafm b\u1eaft,\u201d Page v\u00e0 \u0111\u1ed3ng nghi\u1ec7p c\u1ee7a c\u00f4 cho bi\u1ebft.<\/p>\n

Hi\u1ec7n nay, qua c\u00e1c th\u00ed nghi\u1ec7m \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n k\u1ebft h\u1ee3p m\u00e1y quang ph\u1ed5 NMR, tinh th\u1ec3 h\u1ecdc tia X v\u00e0 c\u00e1c k\u1ef9 thu\u1eadt sinh h\u00f3a, c\u00f4 \u0111\u00e3 t\u00ecm ra \u0111\u01b0\u1ee3c c\u00e1ch th\u1ee9c PP1 li\u00ean k\u1ebft v\u1edbi m\u1ed9t protein m\u1ee5c ti\u00eau \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 PNUTS, h\u00ecnh th\u00e0nh \u201cm\u00f4-t\u00edp r\u00e0ng bu\u1ed9c\u201d. Ki\u1ebfn th\u1ee9c n\u00e0y, k\u1ebft h\u1ee3p v\u1edbi nh\u1eefng g\u00ec c\u00f4 \u0111\u00e3 bi\u1ebft \u00a0trong c\u00e1c nghi\u00ean c\u1ee9u tr\u01b0\u1edbc \u0111\u00e2y v\u1ec1 hai lo\u1ea1i protein m\u1ee5c ti\u00eau kh\u00e1c – NIPP1 v\u00e0 spinophilin – cho ph\u00e9p nh\u00f3m nghi\u00ean c\u1ee9u d\u1ef1 \u0111o\u00e1n c\u00e1ch PP1 li\u00ean k\u1ebft v\u1edbi 43 trong s\u1ed1 200 protein \u0111i\u1ec1u h\u00f2a \u0111em l\u1ea1i cho n\u00f3 h\u00e0nh vi c\u1ee5 th\u1ec3.<\/p>\n

\u201cNh\u1eefng g\u00ec nghi\u00ean c\u1ee9u n\u00e0y k\u1ebft h\u1ee3p v\u1edbi hai nghi\u00ean c\u1ee9u c\u1ea5u tr\u00fac tr\u01b0\u1edbc \u0111\u00f3 c\u1ee7a ch\u00fang t\u00f4i cho ph\u00e9p ch\u00fang t\u00f4i x\u00e1c \u0111\u1ecbnh hai m\u00f4-t\u00edp ho\u00e0n to\u00e0n m\u1edbi\u201d, c\u00f4 n\u00f3i. \u201cT\u1eeb \u0111\u00f3, so s\u00e1nh c\u00e1c tr\u00ecnh t\u1ef1 n\u00e0y v\u1edbi c\u00e1c protein \u0111\u00e3 \u0111\u01b0\u1ee3c bi\u1ebft t\u01b0\u01a1ng t\u00e1c v\u1edbi PP1 c\u00f3 c\u1ea5u tr\u00fac m\u00e0 ch\u00fang t\u00f4i ch\u01b0a n\u1eafm \u0111\u01b0\u1ee3c, ch\u00fang t\u00f4i c\u00f3 th\u1ec3 d\u1ef1 \u0111o\u00e1n r\u1eb1ng 20% trong s\u1ed1 ch\u00fang c\u00f3 th\u1ec3 t\u01b0\u01a1ng t\u00e1c theo m\u1ed9t c\u00e1ch t\u01b0\u01a1ng t\u1ef1 nh\u01b0 ba protein n\u00e0y\u201d.<\/p>\n

V\u00ec v\u1eady, b\u1eb1ng c\u00e1ch gi\u1ea3i quy\u1ebft c\u1ea5u tr\u00fac c\u1ee7a ch\u1ec9 ba protein t\u01b0\u01a1ng t\u00e1c v\u1edbi PP1, Page hi\u1ec7n c\u00f3 ph\u01b0\u01a1ng ti\u1ec7n \u0111\u1ec3 hi\u1ec3u \u0111\u01b0\u1ee3c s\u1ef1 r\u00e0ng bu\u1ed9c c\u1ee7a nhi\u1ec1u protein m\u00e0 kh\u00f4ng c\u1ea7n gi\u1ea3i quy\u1ebft c\u1ea5u tr\u00fac c\u1ee7a ch\u00fang. Thay v\u00e0o \u0111\u00f3, c\u00f4 ch\u1ec9 c\u1ea7n bi\u1ebft m\u1ed9t v\u00e0i m\u00f4-t\u00edp v\u00e0 c\u00e1c tr\u00ecnh t\u1ef1 c\u1ee7a protein.<\/p>\n

C\u00e1c t\u01b0\u01a1ng t\u00e1c c\u1ee7a PP1 v\u1edbi kho\u1ea3ng 80% protein \u0111i\u1ec1u h\u00f2a kh\u00e1c v\u1eabn c\u00f2n l\u00e0 m\u1ed9t b\u00ed \u1ea9n. Nh\u01b0ng Page cho bi\u1ebft th\u00e0nh c\u00f4ng m\u00e0 nh\u00f3m c\u1ee7a c\u00f4 c\u00f3 \u0111\u01b0\u1ee3c trong ph\u00f2ng th\u00ed nghi\u1ec7m nghi\u00ean c\u1ee9u PP1 v\u00e0 gi\u1ea3i quy\u1ebft c\u00e1c m\u00f4-t\u00edp quan tr\u1ecdng l\u00e0m cho c\u00f4 l\u1ea1c quan r\u1eb1ng nh\u1eefng t\u01b0\u01a1ng t\u00e1c n\u00e0y c\u0169ng c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c gi\u1ea3i quy\u1ebft.<\/p>\n

Theo SciTechDaily.<\/em><\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Trong m\u1ed9t nghi\u00ean c\u1ee9u m\u1edbi \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Brown b\u00e1o c\u00e1o m\u1ed9t b\u01b0\u1edbc \u0111\u1ea1i nh\u1ea3y v\u1ecdt trong vi\u1ec7c hi\u1ec3u bi\u1ebft c\u00e1ch th\u1ee9c PP1 t\u01b0\u01a1ng t\u00e1c v\u1edbi c\u00e1c protein kh\u00e1c \u0111\u1ec3 h\u00e0nh x\u1eed kh\u00e1c nhau trong c\u00e1c t\u00ecnh hu\u1ed1ng nh\u1ea5t \u0111\u1ecbnh.\u0110\u0103ng ng\u00e0y 18-03-2014 trong chuy\u00ean m\u1ee5c Tin th\u1ebf […]\n","protected":false},"author":1,"featured_media":6376,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[87],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6639"}],"collection":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/comments?post=6639"}],"version-history":[{"count":0,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6639\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media\/6376"}],"wp:attachment":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media?parent=6639"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/categories?post=6639"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/tags?post=6639"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}