{"id":6647,"date":"2014-02-13T01:42:25","date_gmt":"2014-02-12T18:42:25","guid":{"rendered":"http:\/\/antoansinhhoc.vn\/?p=1877"},"modified":"2014-02-13T01:42:25","modified_gmt":"2014-02-12T18:42:25","slug":"nghien-cuu-ve-gen-gh-growth-hormone-tren-bo","status":"publish","type":"post","link":"https:\/\/nbca.gov.vn\/nghien-cuu-ve-gen-gh-growth-hormone-tren-bo\/","title":{"rendered":"Nghi\u00ean c\u1ee9u v\u1ec1 gen GH (Growth hormone) tr\u00ean b\u00f2"},"content":{"rendered":"
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Qu\u00e1 tr\u00ecnh t\u0103ng tr\u01b0\u1edfng \u1edf \u0111\u1ed9ng v\u1eadt \u0111\u01b0\u1ee3c \u0111i\u1ec1u khi\u1ec3n b\u1edfi m\u1ed9t h\u1ec7 th\u1ed1ng ph\u1ee9c t\u1ea1p, trong \u0111\u00f3 tr\u1ee5c somatotropic \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng. C\u00e1c gen ho\u1ea1t \u0111\u1ed9ng tr\u00ean tr\u1ee5c somatotropic\u00a0ch\u1ecbu tr\u00e1ch nhi\u1ec7m t\u0103ng tr\u01b0\u1edfng, m\u00e0 ch\u1ee7 y\u1ebfu l\u00e0 GH \u0111\u00e3 t\u00e1c \u0111\u1ed9ng l\u00ean s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a x\u01b0\u01a1ng v\u00e0 c\u01a1, \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh l\u00e0 c\u00e1c gen ch\u1ee7 y\u1ebfu trong qu\u00e1 tr\u00ecnh sinh h\u1ecdc v\u00e0 \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong vi\u1ec7c \u0111i\u1ec1u h\u00f2a s\u1ef1 t\u0103ng tr\u01b0\u1edfng v\u00e0 ph\u00e1t tri\u1ec3n.<\/span>\u0110\u0103ng ng\u00e0y 13-02-2014<\/span> trong chuy\u00ean m\u1ee5c Tin th\u1ebf gi\u1edbi<\/a><\/p>\n<\/div>\n

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H\u01a1n n\u1eefa s\u1ef1 thay th\u1ebf leucine \/valine t\u1ea1i v\u1ecb tr\u00ed axit amin 127 c\u1ee7a gen GH c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn t\u1ed1c \u0111\u1ed9 t\u0103ng tr\u01b0\u1edfng, chuy\u1ec3n \u0111\u1ed5i th\u1ee9c \u0103n ti\u00eau th\u1ee5\/ th\u1ee9c \u0103n c\u0169ng nh\u01b0 nh\u1eefng \u0111\u1eb7c \u0111i\u1ec3m th\u00e2n th\u1ecbt \u1edf b\u00f2 s\u1eefa v\u00e0 b\u00f2 th\u1ecbt. Gen GH<\/span>\u00a0l\u00e0 m\u1ed9t peptide \u0111\u01b0\u1ee3c m\u00e3 h\u00f3a b\u1edfi m\u1ed9t gen duy nh\u1ea5t c\u00f3\u00a0 tr\u1ecdng l\u01b0\u1ee3ng\u00a0 ph\u00e2n t\u1eed kho\u1ea3ng 22 KDa, n\u1eb1m tr\u00ean nhi\u1ec5m s\u1eafc th\u1ec3 s\u1ed1 19, d\u00e0i 2.5kb bao g\u1ed3m n\u0103m exon v\u00e0 b\u1ed1n intron (Wallis 1973; Woychick v\u00e0 cs., 1982; Gordon v\u00e0 cs., 1983; Hediger v\u00e0 cs., 1990). M\u1ed9t s\u1ed1 \u0111a h\u00ecnh \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh \u1edf gen GH d\u1ef1a v\u00e0o enzyme gi\u1edbi h\u1ea1n MspI (Cowan v\u00e0 cs., 1989; Hilbert v\u00e0 cs., 1989), theo \u0111\u00f3 Zhang v\u00e0 cs (1993) \u0111\u00e3 x\u00e1c \u0111\u1ecbnh \u0111\u01b0\u1ee3c\u00a0 \u0111a h\u00ecnh trong intron 3 \u1edf v\u1ecb tr\u00ed 1547.\u00a0 Nhi\u1ec1u nghi\u00ean c\u1ee9u kh\u00e1c c\u0169ng nh\u1eadn \u0111\u1ecbnh gen GH \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong s\u1ef1 t\u0103ng tr\u01b0\u1edfng v\u00e0 ph\u00e1t tri\u1ec3n c\u1ee7a \u0111\u1ed9ng v\u1eadt v\u00e0 \u0111\u01b0\u1ee3c xem l\u00e0 m\u1ed9t \u1ee9ng c\u1eed vi\u00ean cho c\u00e1c \u0111\u1eb7c \u0111i\u1ec3m kinh t\u1ebf trong c\u00e1c lo\u00e0i v\u1eadt nu\u00f4i. Theo \u0111\u00f3 c\u00e1c \u0111\u1ed9t bi\u1ebfn c\u1ee7a gen n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c m\u00f4 t\u1ea3 \u1edf b\u00f2 s\u1eefa (Lagziel v\u00e0 cs., 1996; Yao v\u00e0 cs., 1996), b\u00f2 th\u1ecbt (Taylor v\u00e0 cs., 1998;\u00a0 Barendse v\u00e0 cs, 2006), C\u1eebu (Marques MDO v\u00e0 cs., 2006), d\u00ea (Malveiro\u00a0 v\u00e0 cs., 2001), heo (Knorr v\u00e0 cs., 1998), gia c\u1ea7m (Feng v\u00e0 cs., 1997; Kuhnlein v\u00e0 cs., 1997).<\/p>\n

\u00a0K\u1ebft qu\u1ea3\u00a0 nghi\u00ean c\u1ee9u c\u1ee7a Pilla v\u00e0 cs (1994) cho r\u1eb1ng\u00a0 \u1edf gia s\u00fac mang ki\u1ec3u gen BB c\u00f3 chu vi ng\u1ef1c cao nh\u1ea5t v\u00e0 chi\u1ec1u d\u00e0i ng\u1ef1c th\u1ea5p nh\u1ea5t, theo \u0111\u00f3 Chreneck v\u00e0 cs (1998) nh\u1eadn \u0111\u1ecbnh gia s\u00fac mang ki\u1ec3u gen BB c\u00f3 tr\u1ecdng l\u01b0\u1ee3ng c\u01a1 th\u1ec3 th\u1ea5p h\u01a1n c\u00e1c gia s\u00fac mang ki\u1ec3u gen AB, BB \u1edf c\u00e1c l\u1ee9a tu\u1ed5i kh\u00e1c nhau (d\u1eabn li\u1ec7u c\u1ee7a Di Stasio v\u00e0 cs., 2002).<\/span>\u00a0Di Stasio v\u00e0 cs (2002) ti\u1ebfn h\u00e0nh kh\u1ea3o s\u00e1t nghi\u00ean c\u1ee9u gen GH v\u00e0 PIT1 tr\u00ean 287 c\u00e1 th\u1ec3 b\u00ea \u0111\u1ef1c \u1edf \u00dd v\u1edbi c\u00e1c t\u00ednh tr\u1ea1ng li\u00ean qua \u0111\u1ebfn n\u0103ng su\u1ea5t tr\u1ecdng l\u01b0\u1ee3ng l\u00fac 5, 7 v\u00e0 11 th\u00e1ng tu\u1ed5i, t\u0103ng tr\u1ecdng h\u00e0ng ng\u00e0y, k\u00edch th\u01b0\u1edbc vai chi\u1ec1u cao (WH), chi\u1ec1u d\u00e0i th\u00e2n (TL), chu vi ng\u1ef1c (CG) l\u00fac 12 th\u00e1ng tu\u1ed5i v\u00e0 c\u1ea5u t\u1ea1o th\u00e2n th\u1ecbt chi\u1ec1u r\u1ed9ng vai (WW), c\u01a1 b\u1eafp vai (SM), chi\u1ec1u r\u1ed9ng th\u1ecbt th\u0103n (LW), \u0111\u1ed9 d\u00e0y th\u0103n (LT), c\u01a1 b\u1eafp \u0111\u00f9i (TM), x\u01b0\u01a1ng m\u1ecfng (BT), k\u1ebft qu\u1ea3 ch\u01b0a t\u00ecm th\u1ea5y s\u1ef1 li\u00ean k\u1ebft gi\u1eefa gen v\u00e0 t\u00ednh tr\u1ea1ng n\u0103ng su\u1ea5t.<\/p>\n

Gill v\u00e0 cs., 2010. X\u00e1c \u0111\u1ecbnh m\u1ed1i t\u01b0\u01a1ng quan gi\u1eefa \u0111\u1ed9t bi\u1ebfn \u0111i\u1ec3m tr\u00ean nhi\u1ec1u gen ti\u1ebfn c\u1eed v\u00e0 t\u00ednh tr\u1ea1ng th\u1ecbt x\u1ebb v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng th\u1ecbt tr\u00ean qu\u1ea7n th\u1ec3 b\u00f2 lai Angus. K\u1ebft qu\u1ea3 cho th\u1ea5y gen GH c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u00ean m\u1eaft th\u1ecbt v\u00e0 chi\u1ec1u d\u00e0i th\u0103n th\u1ecbt.TheoGrossi<\/em>\u00a0v\u00e0 cs (2010) \u0111a h\u00ecnh GH c\u00f3 \u1ea3nh h\u01b0\u1edfng tr\u1ecdng l\u01b0\u1ee3ng cai s\u1eefa, tr\u1ecdng l\u01b0\u1ee3ng b\u00ea l\u1ee9a \u0111\u1ea7u v\u1edbi \u01b0\u1edbc t\u00ednh ph\u01b0\u01a1ng sai ki\u1ec3u h\u00ecnh t\u01b0\u01a1ng \u1ee9ng 8 v\u00e0 33. T\u1ea7n s\u1ed1 alen c\u1ee7a ki\u1ec3u gen GH \u0111\u01b0\u1ee3c ghi nh\u1eadn c\u1ee7a L, V t\u01b0\u01a1ng \u1ee9ng l\u00e0 0.65 v\u00e0 0.35 cho GH .Tr\u1ecdng l\u01b0\u1ee3ng c\u01a1 th\u1ec3 v\u00e0 kh\u1ea3 n\u0103ng h\u1ea5p th\u1ee5 th\u1ee9c \u0103n ch\u0103n nu\u00f4i ph\u1ee5 thu\u1ed9c r\u1ea5t nhi\u1ec1u v\u00e0o ki\u1ec3u. Trong \u0111\u00f3 ki\u1ec3u gen d\u1ecb h\u1ee3p t\u1eed LV chi\u1ebfm nhi\u1ec1u nh\u1ea5t v\u00e0 c\u00f3 \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn l\u01b0\u1ee3ng th\u1ee9c \u0103n \u0103n. C\u00e1c ki\u1ec3u gen GH c\u0169ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ch\u1ec9 ti\u00eau s\u1ed1 l\u01b0\u1ee3ng (kg) th\u1ecbt trong th\u00e2n th\u1ecbt. Ki\u1ec3u gen \u0111\u1ed3ng h\u1ee3p t\u1eed LL v\u00e0 ki\u1ec3u gen d\u1ecb h\u1ee3p t\u1eed LV \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh c\u00f3 li\u00ean quan \u0111\u1ebfn l\u1eafng \u0111\u1ecdng th\u1ecbt cao h\u01a1n so v\u1edbi ki\u1ec3u gen VV, s\u1ef1 kh\u00e1c bi\u1ec7t \u0111\u1ea1t 3,20 kg (LL v\u00e0 VV) v\u00e0 2,56 kg (LV vs VV).<\/p>\n

Theo IAS<\/i><\/b><\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Qu\u00e1 tr\u00ecnh t\u0103ng tr\u01b0\u1edfng \u1edf \u0111\u1ed9ng v\u1eadt \u0111\u01b0\u1ee3c \u0111i\u1ec1u khi\u1ec3n b\u1edfi m\u1ed9t h\u1ec7 th\u1ed1ng ph\u1ee9c t\u1ea1p, trong \u0111\u00f3 tr\u1ee5c somatotropic \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng. C\u00e1c gen ho\u1ea1t \u0111\u1ed9ng tr\u00ean tr\u1ee5c somatotropic\u00a0ch\u1ecbu tr\u00e1ch nhi\u1ec7m t\u0103ng tr\u01b0\u1edfng, m\u00e0 ch\u1ee7 y\u1ebfu l\u00e0 GH \u0111\u00e3 t\u00e1c \u0111\u1ed9ng l\u00ean s\u1ef1 ph\u00e1t tri\u1ec3n c\u1ee7a x\u01b0\u01a1ng v\u00e0 c\u01a1, \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh […]\n","protected":false},"author":1,"featured_media":6388,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[87],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6647"}],"collection":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/comments?post=6647"}],"version-history":[{"count":0,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6647\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media\/6388"}],"wp:attachment":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media?parent=6647"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/categories?post=6647"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/tags?post=6647"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}