{"id":6660,"date":"2014-03-18T01:20:34","date_gmt":"2014-03-17T18:20:34","guid":{"rendered":"http:\/\/antoansinhhoc.vn\/?p=1811"},"modified":"2014-03-18T01:20:34","modified_gmt":"2014-03-17T18:20:34","slug":"tim-hieu-qua-trinh-tong-hop-dau-nho-gien-cua-vung","status":"publish","type":"post","link":"https:\/\/nbca.gov.vn\/tim-hieu-qua-trinh-tong-hop-dau-nho-gien-cua-vung\/","title":{"rendered":"T\u00ecm hi\u1ec3u qu\u00e1 tr\u00ecnh t\u1ed5ng h\u1ee3p d\u1ea7u nh\u1edd gien c\u1ee7a v\u1eebng"},"content":{"rendered":"
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C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1eeb Vi\u1ec7n Nghi\u00ean c\u1ee9u c\u00e2y c\u00f3 d\u1ea7u c\u1ee7a Vi\u1ec7n H\u00e0n l\u00e2m Khoa h\u1ecdc N\u00f4ng nghi\u1ec7p Trung Qu\u1ed1c (BGI), \u0110\u1ea1i h\u1ecdc Copenhagen v\u00e0 c\u00e1c vi\u1ec7n nghi\u00ean c\u1ee9u kh\u00e1c \u0111\u00e3 th\u00e0nh c\u00f4ng trong b\u1ebb m\u00e3 b\u1ed9 gen c\u1ee7a c\u00e2y v\u1eebng c\u00f3 h\u00e0m l\u01b0\u1ee3ng d\u1ea7u cao, mang l\u1ea1i nh\u1eefng hi\u1ec3u bi\u1ebft m\u1edbi v\u1ec1 giai \u0111o\u1ea1n ph\u00e1t tri\u1ec3n quan tr\u1ecdng c\u1ee7a h\u1ea1t v\u00e0 qu\u00e1 tr\u00ecnh t\u00edch l\u0169y d\u1ea7u, c\u00f9ng v\u1edbi nh\u1eefng gen quan tr\u1ecdng ti\u1ec1m \u1ea9n kh\u1ea3 n\u0103ng s\u1ea3n xu\u1ea5t h\u1ee3p ch\u1ea5t sesamin.<\/span>\u0110\u0103ng ng\u00e0y 18-03-2014<\/span> trong chuy\u00ean m\u1ee5c Tin th\u1ebf gi\u1edbi<\/a><\/p>\n<\/div>\n

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C\u00e1c n\u1ed7 l\u1ef1c chung \u0111\u00e3 khi\u1ebfn cho c\u00e2y v\u1eebng tr\u1edf th\u00e0nh Lamiales (b\u1ed9 Hoa m\u00f4i) th\u1ee9 hai \u0111\u01b0\u1ee3c gi\u1ea3i m\u00e3 gien c\u00f9ng v\u1edbi c\u00e1c b\u1ed9 gien c\u1ee7a lo\u00e0i th\u1ef1c v\u1eadt Nh\u1ec9 c\u00e1n t\u00fai Utricularia gibba \u0111\u00e3 t\u1eebng \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1. Nghi\u00ean c\u1ee9u m\u1edbi nh\u1ea5t \u0111\u01b0\u1ee3c \u0111\u0103ng t\u1ea3i tr\u1ef1c tuy\u1ebfn tr\u00ean t\u1edd Genome Biology.<\/p>\n

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V\u1eebng (danh ph\u00e1p hai ph\u1ea7n l\u00e0 Sesamum indicum L.) \u0111\u01b0\u1ee3c coi l\u00e0 n\u1eef ho\u00e0ng c\u1ee7a c\u00e2y h\u1ea1t d\u1ea7u v\u1edbi h\u00e0m l\u01b0\u1ee3ng d\u1ea7u cao v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng. C\u00e2y tr\u1ed3ng n\u00e0y \u0111\u01b0\u1ee3c tr\u1ed3ng r\u1ed9ng r\u00e3i \u1edf c\u00e1c v\u00f9ng nhi\u1ec7t \u0111\u1edbi v\u00e0 c\u1eadn nhi\u1ec7t \u0111\u1edbi d\u01b0\u1edbi h\u00ecnh th\u1ee9c l\u00e0 m\u1ed9t ngu\u1ed3n cung c\u1ea5p d\u1ea7u v\u00e0 pr\u00f4t\u00eain quan tr\u1ecdng. So v\u1edbi c\u00e1c c\u00e2y tr\u1ed3ng c\u00f3 d\u1ea7u \u0103n \u0111\u01b0\u1ee3c kh\u00e1c nh\u01b0: \u0111\u1eadu t\u01b0\u01a1ng, c\u1ea3i d\u1ea7u, \u0111\u1eadu ph\u1ed9ng v\u00e0 \u00f4 liu, v\u1eebng c\u00f3 \u01b0u th\u1ebf v\u1ec1 h\u00e0m l\u01b0\u1ee3ng d\u1ea7u cao (~ 55% h\u1ea1t kh\u00f4), v\u00e0 do \u0111\u00f3 c\u00e2y v\u1eebng l\u00e0 m\u1ed9t m\u00f4 h\u00ecnh h\u1ea5p d\u1eabn cho nghi\u00ean c\u1ee9u t\u1ed5ng h\u1ee3p lipid. Tuy nhi\u00ean, nh\u1eefng nghi\u00ean c\u1ee9u hi\u1ec7n nay ch\u1ec9 gi\u1edbi h\u1ea1n v\u1ec1 d\u1eef li\u1ec7u gien c\u1ee7a c\u00e2y v\u1eebng.<\/div>\n
Trong nghi\u00ean c\u1ee9u n\u00e0y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 tr\u00ecnh b\u00e0y m\u1ed9t ph\u00e1c th\u1ea3o b\u1ed9 gien c\u1ee7a gi\u1ed1ng v\u1eebng c\u00f3 ch\u1ea5t l\u01b0\u1ee3ng cao l\u00e0 \u201cZhongzhi s\u1ed1 13\u201d – m\u1ed9t gi\u1ed1ng \u01b0u vi\u1ec7t \u1edf Trung Qu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c tr\u1ed3ng trong m\u01b0\u1eddi n\u0103m qua. Sau khi d\u1eef li\u1ec7u \u0111\u01b0\u1ee3c x\u1eed l\u00fd, k\u00edch th\u01b0\u1edbc c\u1ee7a b\u1ed9 gien v\u1eebng \u0111\u00e3 \u0111\u01b0\u1ee3c r\u00e1p l\u1ea1i l\u00e0 kho\u1ea3ng 337 Mb, v\u1edbi t\u1ed5ng s\u1ed1 27.148 gien. K\u1ebft qu\u1ea3 n\u00e0y \u0111\u00e3 l\u00e0m n\u1ed5i b\u1eadt s\u1ef1 v\u1eafng m\u1eb7t c\u1ee7a mi\u1ec1n th\u1ee5 th\u1ec3 Toll\/interleukin-1 trong c\u00e1c gien kh\u00e1ng, v\u00e0 cho r\u1eb1ng \u0111\u00f3 c\u00f3 th\u1ec3 l\u00e0 m\u1ed9t m\u00f4 h\u00ecnh m\u1edbi trong vi\u1ec7c l\u00e0m s\u00e1ng t\u1ecf s\u1ef1 t\u01b0\u01a1ng t\u00e1c c\u1ee7a c\u00e1c gien kh\u00e1ng b\u1ec7nh.<\/div>\n
\u0110\u1ec3 kh\u00e1m ph\u00e1 c\u01a1 ch\u1ebf ph\u00e2n t\u1eed c\u1ee7a sinh t\u1ed5ng h\u1ee3p lipid, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ti\u1ebfn h\u00e0nh c\u00e1c ph\u00e2n t\u00edch gien v\u00e0 transcriptomic (nghi\u00ean c\u1ee9u \u1edf m\u1ee9c \u0111\u1ed9 phi\u00ean m\u00e3 gen) so s\u00e1nh \u0111\u1ed3ng th\u1eddi ph\u00e1t hi\u1ec7n th\u1ea5y m\u1ed9t s\u1ef1 m\u1edf r\u1ed9ng \u1edf gien chuy\u1ec3n lipid lo\u1ea1i 1 b\u1edfi s\u1ef1 tr\u00f9ng l\u1eb7p tr\u01b0\u1edbc sau, s\u1ef1 co l\u1ea1i \u1edf gien suy gi\u1ea3m lipid, v\u00e0 c\u00e1c bi\u1ec3u hi\u1ec7n kh\u00e1c bi\u1ec7t c\u1ee7a c\u00e1c gien c\u1ea7n thi\u1ebft trong con \u0111\u01b0\u1eddng sinh t\u1ed5ng h\u1ee3p triacylglycerol, \u0111\u1eb7c bi\u1ec7t l\u00e0 trong giai \u0111o\u1ea1n \u0111\u1ea7u ph\u00e1t tri\u1ec3n c\u1ee7a h\u1ea1t. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ti\u1ebfp t\u1ee5c gi\u1ea3i m\u00e3 l\u1ea1i 29 gi\u1ed1ng v\u1eebng b\u1ed5 sung t\u1eeb 12 qu\u1ed1c gia \u0111\u1ec3 nghi\u00ean c\u1ee9u \u0111a d\u1ea1ng di truy\u1ec1n c\u1ee7a gien li\u00ean quan \u0111\u1ebfn lipid.<\/div>\n
Sesamin l\u00e0 m\u1ed9t h\u1ee3p ch\u1ea5t furofuran lignan tan trong d\u1ea7u th\u01b0\u1eddng c\u00f3 trong h\u1ea1t v\u1eebng. Nhi\u1ec1u nghi\u00ean c\u1ee9u ti\u1ebfn h\u00e0nh tr\u00ean chu\u1ed9t \u0111\u00e3 cho th\u1ea5y l\u1ee3i \u00edch s\u1ee9c kh\u1ecfe kh\u00e1c nhau c\u1ee7a sesamin. H\u1ee3p ch\u1ea5t n\u00e0y \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u1ebfn v\u1edbi kh\u1ea3 n\u0103ng \u0111\u01b0a huy\u1ebft \u00e1p v\u1ec1 m\u1ee9c b\u00ecnh th\u01b0\u1eddng, gi\u1ea3m cholesterol, b\u1ea3o v\u1ec7 gan, v\u00e0 g\u00f3p ph\u1ea7n l\u00e0m gi\u1ea3m c\u00e2n. Sinh t\u1ed5ng h\u1ee3p sesamin li\u00ean quan \u0111\u1ebfn hai gien quan tr\u1ecdng m\u00e3 h\u00f3a pr\u00f4t\u00eain dirigent (DIR) v\u00e0 piperitol\/sesamin synthase (PSS), t\u01b0\u01a1ng \u1ee9ng. Trong nghi\u00ean c\u1ee9u n\u00e0y, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u ph\u00e1t hi\u1ec7n ra r\u1eb1ng, ch\u1ea5t \u0111\u1ed3ng \u0111\u1eb3ng DIR \u0111\u00e3 hi\u1ec7n di\u1ec7n \u1edf v\u1eebng v\u00e0 c\u00e0 chua, nh\u01b0ng PSSs ch\u1ec9 ph\u00e1t hi\u1ec7n th\u1ea5y \u1edf v\u1eebng, bi\u1ec3u th\u1ecb c\u01a1 s\u1edf di truy\u1ec1n cho c\u00e1c s\u1ea3n ph\u1ea9m c\u1ee5 th\u1ec3 c\u1ee7a v\u1eebng.<\/div>\n
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C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1eeb Vi\u1ec7n Nghi\u00ean c\u1ee9u c\u00e2y c\u00f3 d\u1ea7u c\u1ee7a Vi\u1ec7n H\u00e0n l\u00e2m Khoa h\u1ecdc N\u00f4ng nghi\u1ec7p Trung Qu\u1ed1c (BGI), \u0110\u1ea1i h\u1ecdc Copenhagen v\u00e0 c\u00e1c vi\u1ec7n nghi\u00ean c\u1ee9u kh\u00e1c \u0111\u00e3 th\u00e0nh c\u00f4ng trong b\u1ebb m\u00e3 b\u1ed9 gen c\u1ee7a c\u00e2y v\u1eebng c\u00f3 h\u00e0m l\u01b0\u1ee3ng d\u1ea7u cao, mang l\u1ea1i nh\u1eefng hi\u1ec3u bi\u1ebft m\u1edbi v\u1ec1 giai […]\n","protected":false},"author":1,"featured_media":6375,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[87],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6660"}],"collection":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/comments?post=6660"}],"version-history":[{"count":0,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6660\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media\/6375"}],"wp:attachment":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media?parent=6660"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/categories?post=6660"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/tags?post=6660"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}