{"id":6723,"date":"2015-05-30T08:43:31","date_gmt":"2015-05-30T01:43:31","guid":{"rendered":"http:\/\/antoansinhhoc.vn\/?p=1395"},"modified":"2015-05-30T08:43:31","modified_gmt":"2015-05-30T01:43:31","slug":"vi-rut-bien-doi-gen-chua-khoi-ung-thu-da","status":"publish","type":"post","link":"https:\/\/nbca.gov.vn\/vi-rut-bien-doi-gen-chua-khoi-ung-thu-da\/","title":{"rendered":"Vi r\u00fat bi\u1ebfn \u0111\u1ed5i gen ch\u1eefa kh\u1ecfi ung th\u01b0 da"},"content":{"rendered":"
M\u1ed9t vi r\u00fat bi\u1ebfn \u0111\u1ed5i gen \u0111\u00e3 ch\u1eefa kh\u1ecfi cho b\u1ec7nh nh\u00e2n ung th\u01b0 da. \u0110\u00e2y \u0111\u01b0\u1ee3c coi l\u00e0 b\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 \u0111\u1ea7u ti\u00ean tr\u00ean th\u1ebf gi\u1edbi, l\u00e0m t\u0103ng m\u1ed1i hy v\u1ecdng v\u1ec1 s\u1ef1 c\u00e1o chung c\u1ee7a h\u00f3a tr\u1ecb li\u1ec7u.<\/b><\/span><\/div>\n
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Li\u1ec7u ph\u00e1p m\u1edbi c\u00f3 \u00edt t\u00e1c d\u1ee5ng ph\u1ee5 h\u01a1n nhi\u1ec1u v\u00ec n\u00f3 huy \u0111\u1ed9ng h\u1ec7 mi\u1ec5n d\u1ecbch c\u1ee7a ch\u00ednh c\u01a1 th\u1ec3.<\/div>\n
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Trong nghi\u00ean c\u1ee9u tr\u00ean to\u00e0n th\u1ebf gi\u1edbi, do Vi\u1ec7n Nghi\u00ean c\u1ee9u ung th\u01b0 Anh ti\u1ebfn h\u00e0nh, c\u00e1c nh\u00e0 khoa h\u1ecdc th\u1ea5y r\u1eb1ng c\u00e1ch \u0111i\u1ec1u tr\u1ecb m\u1edbi n\u00e0y cho ph\u00e9p m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n ung th\u01b0 da s\u1ed1ng th\u00eam \u0111\u01b0\u1ee3c h\u01a1n 3 n\u0103m – m\u1ed9t m\u1ed1c m\u00e0 nhi\u1ec1u chuy\u00ean gia v\u1ec1 b\u1ec7nh ung th\u01b0 s\u1eed d\u1ee5ng \u0111\u1ec3 \u0111\u1ecbnh ngh\u0129a v\u1ec1 kh\u1ecfi b\u1ec7nh.<\/div>\n
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Li\u1ec7u ph\u00e1p c\u00f3 t\u00ean l\u00e0 T-VEC, g\u00e2y nhi\u1ec5m v\u00e0 ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0, \u0111\u1ed3ng th\u1eddi c\u0169ng th\u00fac \u0111\u1ea9y h\u1ec7 mi\u1ec5n d\u1ecbch t\u1ea5n c\u00f4ng kh\u1ed1i u.<\/div>\n
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Hi\u1ec7n nay h\u1ea7u h\u1ebft c\u00e1c tr\u01b0\u1eddng h\u1ee3p ung th\u01b0 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng h\u00f3a tr\u1ecb, x\u1ea1 tr\u1ecb v\u00e0 ph\u1eabu thu\u1eadt, t\u1ea5t c\u1ea3 nh\u1eefng bi\u1ec7n ph\u00e1p n\u00e0y \u0111\u1ec1u c\u00f3 nguy c\u01a1 g\u00e2y h\u1ea1i.<\/div>\n
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Li\u1ec7u ph\u00e1p m\u1edbi c\u00f3 \u00edt t\u00e1c d\u1ee5ng ph\u1ee5 h\u01a1n nhi\u1ec1u v\u00e0 kh\u00f4ng g\u00e2y t\u1ed5n th\u01b0\u01a1ng cho t\u1ebf b\u00e0o ho\u1eb7c m\u00f4 b\u00ecnh th\u01b0\u1eddng.<\/div>\n
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C\u00e1c th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng \u0111\u00e3 \u0111\u01b0\u1ee3c ti\u1ebfn h\u00e0nh trong h\u01a1n 3 n\u0103m \u1edf 64 c\u01a1 s\u1edf t\u1ea1i Anh, M\u1ef9, Canada v\u00e0 Nam Phi.<\/div>\n
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K\u1ebft qu\u1ea3 cho th\u1ea5y 163 b\u1ec7nh nh\u00e2n b\u1ecb u h\u1eafc t\u1ed1 gi\u1ea3i \u0111o\u1ea1n 3 v\u00e0 \u0111\u1ea7u giai \u0111o\u1ea1n 4 \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb b\u1eb1ng T-VEC \u0111\u00e3 s\u1ed1ng th\u00eam \u0111\u01b0\u1ee3c trung b\u00ecnh 41 th\u00e1ng, so v\u1edbi th\u1eddi gian s\u1ed1ng th\u00eam trung b\u00ecnh ch\u1ec9 21,5 th\u00e1ng \u1edf 66 b\u1ec7nh nh\u00e2n \u0111\u01b0\u1ee3c d\u00f9ng c\u00e1c thu\u1ed1c h\u00f3a tr\u1ecb t\u1ed1t nh\u1ea5t hi\u1ec7n nay.<\/div>\n
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V\u00e0 \u0111\u00e1p \u1ee9ng c\u0169ng r\u00f5 nh\u1ea5t \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n b\u1ecb ung th\u01b0 giai \u0111o\u1ea1n s\u1edbm h\u01a1n, cho th\u1ea5y l\u1ee3i \u00edch c\u1ee7a ph\u01b0\u01a1ng ph\u00e1p n\u00e0y nh\u01b0 m\u1ed9t tr\u1ecb li\u1ec7u \u0111\u1ea7u b\u1ea3ng cho nh\u1eefng tr\u01b0\u1eddng h\u1ee3p ung th di c\u0103n kh\u00f4ng th\u1ec3 ph\u1eabu thu\u1eadt \u0111\u01b0\u1ee3c.<\/div>\n
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T-VEC l\u00e0 d\u1ea1ng vi r\u00fat herpes bi\u1ebfn \u0111\u1ed5i nh\u00e2n l\u00ean trong t\u1ebf b\u00e0o ung th\u01b0 v\u00e0 ph\u00e1 h\u1ee7y t\u1ebf b\u00e0o ung th\u01b0 t\u1eeb trong ra. Vi r\u00fat n\u00e0y \u0111\u00e3 \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i gen \u0111\u1ec3 sinh ra m\u1ed9t ph\u00e2n t\u1eed l\u00e0 GM-CSF, k\u00edch th\u00edch h\u1ec7 mi\u1ec5n d\u1ecbch t\u1ea5n c\u00f4ng v\u00e0 ph\u00e1 h\u1ee7y kh\u1ed5i u.<\/div>\n
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Vi r\u00fat c\u0169ng \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i \u0111\u1ec3 lo\u1ea1i \u0111i 2 gen ch\u00ednh khi\u1ebfn n\u00f3 kh\u00f4ng th\u1ec3 nh\u00e2n l\u00ean trong t\u1ebf b\u00e0o kh\u1ecfe m\u1ea1nh. T\u1ebf b\u00e0o b\u00ecnh th\u01b0\u1eddng s\u1ebd ph\u00e1t hi\u1ec7n v\u00e0 ph\u00e1 h\u1ee7y T-VEC tr\u01b0\u1edbc khi n\u00f3 c\u00f3 th\u1ec3 g\u00e2y h\u1ea1i, nh\u01b0ng vi r\u00fat s\u1ebd d\u1ec5 d\u00e0ng nh\u00e2n l\u00ean trong t\u1ebf b\u00e0o ung th\u01b0 v\u00ec h\u1ec7 th\u1ed1ng ph\u00f2ng ng\u1ef1 c\u1ee7a nh\u1eefng t\u1ebf b\u00e0o n\u00e0y b\u1ecb gi\u1ea3m s\u00fat do nh\u1eefng sai s\u00f3t v\u1ec1 di truy\u1ec1n.<\/div>\n
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\u0110\u00e2y l\u00e0 m\u1ed9t trong nh\u1eefng thu\u1ed1c m\u1edbi t\u1eeb vi r\u00fat cho th\u1ea5y l\u1ee3i \u00edch trong c\u00e1c th\u1eed nghi\u1ec7m v\u1ec1 ung th\u01b0, l\u00e0 hi\u1ec7n l\u00e0 thu\u1ed1c \u0111\u1ea7u ti\u00ean ch\u1ee9ng minh hi\u1ec7u qu\u1ea3 trong th\u1eed nghi\u1ec7m l\u1edbn giai \u0111o\u1ea1n III.<\/div>\n
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U h\u1eafc t\u1ed1 \u00e1c t\u00ednh, hay ung th\u01b0 da, l\u00e0 m\u1ed9t trong n\u0103m ung th\u01b0 hay g\u1eb7p nh\u1ea5t \u1edf Anh, v\u1edbi 13.000 tr\u01b0\u1eddng h\u1ee3p \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n v\u00e0 h\u01a1n 2000 ng\u01b0\u1eddi ch\u1ebft m\u1ed7i n\u0103m<\/div>\n
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Th\u1eed nghi\u1ec7m \u0111\u01b0\u1ee3c t\u00e0i tr\u1ee3 b\u1edfi nh\u00e0 s\u1ea3n xu\u1ea5t T-VEC l\u00e0 c\u00f4ng ty Amgen, v\u00e0 \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed Journal of Clinical Oncology.<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

M\u1ed9t vi r\u00fat bi\u1ebfn \u0111\u1ed5i gen \u0111\u00e3 ch\u1eefa kh\u1ecfi cho b\u1ec7nh nh\u00e2n ung th\u01b0 da. \u0110\u00e2y \u0111\u01b0\u1ee3c coi l\u00e0 b\u01b0\u1edbc \u0111\u1ed9t ph\u00e1 \u0111\u1ea7u ti\u00ean tr\u00ean th\u1ebf gi\u1edbi, l\u00e0m t\u0103ng m\u1ed1i hy v\u1ecdng v\u1ec1 s\u1ef1 c\u00e1o chung c\u1ee7a h\u00f3a tr\u1ecb li\u1ec7u. Li\u1ec7u ph\u00e1p m\u1edbi c\u00f3 \u00edt t\u00e1c d\u1ee5ng ph\u1ee5 h\u01a1n nhi\u1ec1u v\u00ec n\u00f3 huy \u0111\u1ed9ng h\u1ec7 […]\n","protected":false},"author":1,"featured_media":1415,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[87],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6723"}],"collection":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/comments?post=6723"}],"version-history":[{"count":0,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6723\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media\/1415"}],"wp:attachment":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media?parent=6723"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/categories?post=6723"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/tags?post=6723"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}