{"id":6747,"date":"2015-12-01T07:22:28","date_gmt":"2015-12-01T00:22:28","guid":{"rendered":"http:\/\/antoansinhhoc.vn\/?p=1025"},"modified":"2015-12-01T07:22:28","modified_gmt":"2015-12-01T00:22:28","slug":"tao-bien-doi-gen-diet-toi-hon-90-te-bao-ung-thu-khong-lam-hai-te-bao-khac","status":"publish","type":"post","link":"https:\/\/nbca.gov.vn\/tao-bien-doi-gen-diet-toi-hon-90-te-bao-ung-thu-khong-lam-hai-te-bao-khac\/","title":{"rendered":"T\u1ea3o bi\u1ebfn \u0111\u1ed5i gen di\u1ec7t t\u1edbi h\u01a1n 90% t\u1ebf b\u00e0o ung th\u01b0, kh\u00f4ng l\u00e0m h\u1ea1i t\u1ebf b\u00e0o kh\u00e1c"},"content":{"rendered":"

Vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh hi\u1ec7u qu\u1ea3 \u0111\u1ed1i v\u1edbi c\u00e1c kh\u1ed1i u \u1edf chu\u1ed9t m\u00e0 kh\u00f4ng l\u00e0m \u1ea3nh h\u01b0\u1edfng t\u1edbi c\u00e1c ph\u1ea7n kh\u00e1c c\u1ee7a c\u01a1 th\u1ec3.<\/p>\n

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Trong v\u00e0i th\u00e1ng tr\u1edf l\u1ea1i \u0111\u00e2y, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 li\u00ean t\u1ee5c \u0111\u01b0a ra nh\u1eefng “v\u0169 kh\u00ed ” m\u1edbi h\u1ed7 tr\u1ee3 con ng\u01b0\u1eddi trong cu\u1ed9c chi\u1ebfn ch\u1ed1ng l\u1ea1i c\u0103n b\u1ec7nh ung th\u01b0 qu\u00e1i \u00e1c. C\u00e1ch \u0111\u00e2y kh\u00f4ng l\u00e2u, c\u00e1c chuy\u00ean gia sinh h\u1ecdc t\u1ea1i \u0111\u1ea1i h\u1ecdc Nam Australia \u0111\u00e3 ph\u1ed1i h\u1ee3p v\u1edbi m\u1ed9t s\u1ed1 nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i \u0110\u1ee9c \u0111\u00e3 t\u1ea1o th\u00e0nh c\u00f4ng m\u1ed9t lo\u1ea1i t\u1ea3o t\u00ed hon bi\u1ebfn \u0111\u1ed5i gen c\u00f3 th\u1ec3 ti\u00eau di\u1ec7t 90% t\u1ebf b\u00e0o ung th\u01b0 m\u00e0 kh\u00f4ng l\u00e0m t\u1ed5n h\u1ea1i \u0111\u1ebfn c\u00e1c t\u1ebf b\u00e0o kh\u1ecfe m\u1ea1nh kh\u00e1c.<\/p>\n<\/div>\n

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Vi\u1ec7c ph\u00e1t tri\u1ec3n c\u00e1c lo\u1ea1i thu\u1ed1c c\u00f3 th\u1ec3 t\u1ea5n c\u00f4ng tr\u1ef1c ti\u1ebfp c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 trong c\u01a1 th\u1ec3 m\u00e0 kh\u00f4ng l\u00e0m \u1ea3nh h\u01b0\u1edfng t\u1edbi c\u00e1c ph\u1ea7n kh\u00e1c c\u1ee7a c\u01a1 th\u1ec3 l\u00e0 m\u1ed9t th\u00e1ch th\u1ee9c l\u1edbn \u0111\u1ed1i v\u1edbi vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ung th\u01b0. Ch\u1eb3ng h\u1ea1n nh\u01b0 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p h\u00f3a tr\u1ecb c\u00f3 th\u1ec3 g\u00e2y ra nh\u1eefng t\u00e1c d\u1ee5ng ph\u1ee5 \u0111\u1ed1i v\u1edbi t\u00f3c, m\u00f3c tay th\u1eadm ch\u00ed x\u01b0\u01a1ng t\u1ee7y b\u1ec7nh nh\u00e2n. M\u1eb7c d\u00f9 v\u1eady, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 t\u00ecm ra m\u1ed9t xu h\u01b0\u1edbng m\u1edbi l\u00e0 t\u1ea1o ra c\u00e1c lo\u1ea1i thu\u1ed1c d\u1ef1a tr\u00ean c\u00e1c h\u1ea1t nano, \u0111\u01b0a v\u00e0o c\u01a1 th\u1ec3 \u0111\u1ec3 t\u1ea5n c\u00f4ng c\u00e1c t\u1ebf b\u00e0o ung th\u01b0. Vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh hi\u1ec7u qu\u1ea3 \u0111\u1ed1i v\u1edbi c\u00e1c kh\u1ed1i u \u1edf chu\u1ed9t m\u00e0 kh\u00f4ng l\u00e0m \u1ea3nh h\u01b0\u1edfng t\u1edbi c\u00e1c ph\u1ea7n kh\u00e1c c\u1ee7a c\u01a1 th\u1ec3.<\/p>\n<\/div>\n

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Tuy nhi\u00ean, vi\u1ec7c s\u1ea3n xu\u1ea5t c\u00e1c lo\u1ea1i h\u1ea1t nano – \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 biosilica – n\u00e0y c\u00f3 chi ph\u00ed r\u1ea5t cao v\u00e0 y\u00eau c\u1ea7u c\u00e1c h\u00f3a ch\u1ea5t c\u00f4ng nghi\u1ec7p, ch\u1eb3ng h\u1ea1n nh\u01b0 axit flohydric. Gi\u00e1o s\u01b0 Nico Voelcker, m\u1ed9t ng\u01b0\u1eddi c\u00f3 kinh nghi\u1ec7m trong ng\u00e0nh k\u1ef9 thu\u1eadt sinh h\u1ecdc v\u00e0 khoa h\u1ecdc nano c\u1ee7a \u0111\u1ea1i h\u1ecdc Nam Australia, cho bi\u1ebft: “C\u00e1c d\u1eef li\u1ec7u ch\u1ec9 ra t\u1ea3o \u0111\u0129a (biosilica frustules) c\u00f3 th\u1ec3 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng nh\u01b0 m\u1ed9t ph\u01b0\u01a1ng ti\u1ec7n linh ho\u1ea1t nh\u1eb1m \u0111\u01b0a thu\u1ed1c ch\u1ed1ng ung th\u01b0 kh\u00f3 h\u00f2a tan trong n\u01b0\u1edbc \u0111\u1ebfn khu v\u1ef1c kh\u1ed1i u. D\u00f9 v\u1eabn c\u00f2n \u1edf giai \u0111o\u1ea1n ph\u00e1t tri\u1ec3n ban \u0111\u1ea7u, h\u1ec7 th\u1ed1ng v\u1eadn chuy\u1ec3n thu\u1ed1c m\u1edbi d\u1ef1a tr\u00ean v\u1eadt li\u1ec7u d\u1ec5 t\u00e1i t\u1ea1o v\u00e0 \u0111i\u1ec1u ch\u1ec9nh b\u1eb1ng c\u00f4ng ngh\u1ec7 sinh h\u1ecdc, c\u00f3 th\u1ec3 l\u00e0 ch\u00eca kh\u00f3a \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb u c\u1ee9ng, bao g\u1ed3m nh\u1eefng kh\u1ed1i u n\u00e3o hi\u1ec7n ch\u01b0a c\u00f3 c\u00e1ch ch\u1eefa tr\u1ecb”.<\/p>\n<\/div>\n

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T\u1ea3o \u0111\u0129a l\u00e0 m\u1ed9t lo\u1ea1i t\u1ea3o r\u1ea5t nh\u1ecf d\u1ea1ng \u0111\u01a1n b\u00e0o v\u00e0 t\u1ed3n t\u1ea1i b\u1eb1ng quang h\u1ee3p. N\u00f3 c\u00f3 \u0111\u01b0\u1eddng k\u00ednh 4 – 6 micromet v\u00e0 \u0111\u01b0\u1ee3c bao quanh b\u1edfi m\u1ed9t b\u1ed9 khung r\u1ed7 l\u00e0m t\u1eeb silica. Do h\u00f3a ch\u1ea5t tr\u1ecb li\u1ec7u r\u1ea5t \u0111\u1ed9c v\u1edbi m\u00f4 kh\u1ecfe m\u1ea1nh, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u c\u00f3 th\u1ec3 c\u1ea5t thu\u1ed1c b\u00ean trong t\u1ea3o. Nh\u00f3m nghi\u00ean c\u1ee9u s\u1eed d\u1ee5ng c\u00f4ng ngh\u1ec7 bi\u1ebfn \u0111\u1ed5i gene tr\u00ean t\u1ea3o \u0111\u0129a \u0111\u1ec3 s\u1ea3n sinh m\u1ed9t lo\u1ea1i protein li\u00ean k\u1ebft v\u1edbi kh\u00e1ng th\u1ec3 tr\u00ean b\u1ec1 m\u1eb7t l\u1edbp v\u1ecf c\u1ee7a ch\u00fang. Lo\u1ea1i protein n\u00e0y ch\u1ec9 li\u00ean k\u1ebft v\u1edbi nh\u1eefng ph\u00e2n t\u1eed tr\u00ean t\u1ebf b\u00e0o ung th\u01b0 v\u00e0 c\u00f3 th\u1ec3 \u0111\u01b0a thu\u1ed1c \u0111\u1ebfn nh\u1eefng t\u1ebf b\u00e0o \u0111\u00edch.<\/p>\n<\/div>\n

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\u0110\u1ec3 ki\u1ec3m tra t\u00ednh kh\u1ea3 thi c\u1ee7a \u00fd t\u01b0\u1edfng n\u00e0y, Nico v\u00e0 \u0111\u1ed3ng nghi\u1ec7p \u0111\u00e3 l\u1ef1a ch\u1ecdn m\u1ee5c ti\u00eau th\u1eed nghi\u1ec7m l\u00e0 u nguy\u00ean b\u00e0o th\u1ea7n kinh (neuroblastoma) tr\u00ean nh\u1eefng con chu\u1ed9t th\u00ed nghi\u1ec7m. \u0110\u00e2y l\u00e0 m\u1ed9t lo\u1ea1i u ph\u00f4i c\u1ee7a h\u1ec7 th\u1ea7n kinh t\u1ef1 \u0111\u1ed9ng, \u1edf \u0111\u00f3 t\u1ebf b\u00e0o kh\u1edfi \u0111\u1ea7u l\u00e0 t\u1ebf b\u00e0o ti\u1ec1n th\u00e2n \u0111ang ph\u00e1t tri\u1ec3n v\u00e0 ch\u01b0a bi\u1ec7t h\u00f3a xu\u1ea5t ph\u00e1t t\u1eeb m\u00f4 m\u00e0o th\u1ea7n kinh. Ch\u00ednh v\u00ec th\u1ebf, neuroblastoma th\u01b0\u1eddng x\u1ea3y ra v\u1edbi c\u00e1c tr\u1ebb em r\u1ea5t nh\u1ecf, \u0111\u1ed9 tu\u1ed5i trung b\u00ecnh cho ch\u1ea9n \u0111o\u00e1n l\u00e0 kho\u1ea3ng 17 th\u00e1ng; \u0111\u00e2y ch\u00ednh l\u00e0 lo\u1ea1i ung th\u01b0 ph\u1ed5 bi\u1ebfn nh\u1ea5t \u0111\u01b0\u1ee3c ch\u1ea9n \u0111o\u00e1n trong n\u0103m \u0111\u1ea7u ti\u00ean c\u1ee7a cu\u1ed9c \u0111\u1eddi. T\u1ef7 l\u1ec7 m\u1eafc m\u1edbi c\u1ee7a neuroblastoma l\u00e0 10,2\/1.000.000 tr\u1ebb d\u01b0\u1edbi 15 tu\u1ed5i.<\/p>\n<\/div>\n

Sau khi ti\u00eam c\u00e1c h\u1ea1t biosilica v\u00e0o c\u01a1 th\u1ec3 chu\u1ed9t nhi\u1ec5m b\u1ec7nh, \u0111\u1ed9i ng\u0169 nghi\u00ean c\u1ee9u \u0111\u00e3 r\u1ea5t vui m\u1eebng khi k\u1ebft qu\u1ea3 cho th\u1ea5y ch\u1ec9 1 l\u1ea7n ti\u00eam \u0111\u00e3 ti\u00eau di\u1ec7t \u0111\u1ebfn 90% s\u1ed1 l\u01b0\u1ee3ng c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 c\u00f3 trong c\u01a1 th\u1ec3 c\u1ee7a \u0111\u1ed1i t\u01b0\u1ee3ng th\u1eed nghi\u1ec7m. Do t\u1ea3o ch\u1ee7 y\u1ebfu ph\u00e1t tri\u1ec3n d\u1ef1a v\u00e0o n\u01b0\u1edbc v\u00e0 \u00e1nh s\u00e1ng, nh\u00f3m nghi\u00ean c\u1ee9u tin r\u1eb1ng k\u1ef9 thu\u1eadt n\u00e0y s\u1ebd gi\u00fap gi\u1ea3m chi ph\u00ed c\u0169ng nh\u01b0 ch\u1ea5t th\u1ea3i t\u1eeb qu\u00e1 tr\u00ecnh s\u1ea3n xu\u1ea5t ph\u00e2n t\u1eed nano v\u00e0 c\u00f3 ti\u1ec1m n\u0103ng l\u1edbn \u0111\u1ed1i v\u1edbi ch\u1eefa tr\u1ecb ung th\u01b0 trong t\u01b0\u01a1ng lai. Ngo\u00e0i ra, Nico Voeclcker c\u0169ng cho bi\u1ebft r\u1eb1ng \u00f4ng c\u00f3 d\u1ef1 \u0111\u1ecbnh nh\u1ed3i nhi\u1ec1u lo\u1ea1i thu\u1ed1c ch\u1ed1ng ung th\u01b0 v\u00e0o m\u1ed9t h\u1ea1t biosilica \u0111\u1ec3 c\u00f3 th\u1ec3 s\u1eed d\u1ee5ng n\u00f3 nh\u01b0 m\u1ed9t “qu\u1ea3 t\u00ean l\u1eeda \u0111a n\u0103ng” ti\u00eau di\u1ec7t nh\u1eefng kh\u1ed1i u \u00e1c t\u00ednh trong c\u01a1 th\u1ec3 ng\u01b0\u1eddi.<\/div>\n
\"tao-bien-doi-gen-diet-toi-hon-90-te-bao-ung-thu-khong-lam-hai-te-bao-khac\"<\/a><\/div>\n
H\u00ecnh \u1ea3nh m\u00f4 t\u1ea3 qu\u00e1 tr\u00ecnh c\u00e1c h\u1ea1t biosilica ti\u1ebfp c\u1eadn v\u00e0 t\u1ea5n c\u00f4ng c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 b\u1eb1ng c\u00e1ch “th\u1ea3 bom” c\u00e1c lo\u1ea1i thu\u1ed1c ch\u1ed1ng ung th\u01b0.<\/em><\/div>\n","protected":false},"excerpt":{"rendered":"

Vi\u1ec7c \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u00e3 \u0111\u01b0\u1ee3c ch\u1ee9ng minh hi\u1ec7u qu\u1ea3 \u0111\u1ed1i v\u1edbi c\u00e1c kh\u1ed1i u \u1edf chu\u1ed9t m\u00e0 kh\u00f4ng l\u00e0m \u1ea3nh h\u01b0\u1edfng t\u1edbi c\u00e1c ph\u1ea7n kh\u00e1c c\u1ee7a c\u01a1 th\u1ec3. Trong v\u00e0i th\u00e1ng tr\u1edf l\u1ea1i \u0111\u00e2y, c\u00e1c nh\u00e0 khoa h\u1ecdc \u0111\u00e3 li\u00ean t\u1ee5c \u0111\u01b0a ra nh\u1eefng “v\u0169 kh\u00ed ” m\u1edbi h\u1ed7 tr\u1ee3 con ng\u01b0\u1eddi trong […]\n","protected":false},"author":1,"featured_media":6292,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[87],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6747"}],"collection":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/comments?post=6747"}],"version-history":[{"count":0,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6747\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media\/6292"}],"wp:attachment":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media?parent=6747"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/categories?post=6747"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/tags?post=6747"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}