{"id":6750,"date":"2015-12-01T07:30:46","date_gmt":"2015-12-01T00:30:46","guid":{"rendered":"http:\/\/antoansinhhoc.vn\/?p=1075"},"modified":"2015-12-01T07:30:46","modified_gmt":"2015-12-01T00:30:46","slug":"ky-thuat-bien-doi-gene-co-the-tieu-diet-benh-sot-ret","status":"publish","type":"post","link":"https:\/\/nbca.gov.vn\/ky-thuat-bien-doi-gene-co-the-tieu-diet-benh-sot-ret\/","title":{"rendered":"K\u1ef9 thu\u1eadt bi\u1ebfn \u0111\u1ed5i gene c\u00f3 th\u1ec3 ti\u00eau di\u1ec7t b\u1ec7nh s\u1ed1t r\u00e9t"},"content":{"rendered":"

M\u1ed9t c\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u c\u1ee7a c\u00e1c nh\u00e0 khoa h\u1ecdc M\u1ef9 s\u1ebd gi\u00fap cho gene ch\u1ed1ng s\u1ed1t r\u00e9t \u0111\u01b0\u1ee3c di truy\u1ec1n r\u1ed9ng kh\u1eafp trong qu\u1ea7n th\u1ec3 mu\u1ed7i, khi\u1ebfn cho lo\u00e0i c\u00f4n tr\u00f9ng n\u00e0y m\u1ea5t kh\u1ea3 n\u0103ng l\u00e2y truy\u1ec1n c\u0103n b\u1ec7nh ch\u1ebft ng\u01b0\u1eddi tr\u00ean cho con ng\u01b0\u1eddi.<\/p>\n

Theo Engadget, m\u1ed9t nghi\u00ean c\u1ee9u m\u1edbi \u0111\u01b0\u1ee3c h\u1ee3p t\u00e1c gi\u1eefa c\u00e1c tr\u01b0\u1eddng \u0110H California, Irvine v\u00e0 San Diego (UCI), v\u1eeba \u0111\u01b0a ra c\u00f3 th\u1ec3 gi\u00fap \u0111\u1ea9y l\u00f9i hi\u1ec3m h\u1ecda s\u1ed1t r\u00e9t v\u00e0o qu\u00e1 kh\u1ee9. Nghi\u00ean c\u1ee9u n\u00e0y, \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 tr\u00ean t\u1ea1p ch\u00ed PNAS h\u1ed3i \u0111\u1ea7u tu\u1ea7n, s\u1ebd s\u1eed d\u1ee5ng m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p bi\u1ebfn \u0111\u1ed5i gene khi\u1ebfn cho lo\u00e0i mu\u1ed7i kh\u00f4ng th\u1ec3 mang theo m\u1ea7m b\u1ec7nh s\u1ed1t r\u00e9t.<\/div>\n
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Lo\u00e0i mu\u1ed7i c\u00f3 kh\u1ea3 n\u0103ng truy\u1ec1n b\u1ec7nh s\u1ed1t r\u00e9t khi ch\u00fang b\u1ecb nhi\u1ec5m lo\u00e0i k\u00fd sinh Plasmodium. C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 bi\u1ebfn \u0111\u1ed5i gene th\u00e0nh c\u00f4ng cho lo\u00e0i mu\u1ed7i tr\u00ean \u0111\u1ec3 gi\u00fap ch\u00fang tr\u00e1nh \u0111\u01b0\u1ee3c lo\u00e0i k\u00fd sinh n\u00e0y. Nh\u01b0ng \u0111\u00e2y ch\u1ec9 m\u1edbi l\u00e0 m\u1ed9t ph\u1ea7n c\u1ee7a v\u1ea5n \u0111\u1ec1 – l\u00e0m sao \u0111\u1ec3 h\u1ea7u h\u1ebft m\u1ecdi con mu\u1ed7i \u0111\u1ec1u \u0111\u01b0\u1ee3c nh\u01b0 v\u1eady?<\/div>\n
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C\u00e2u tr\u1ea3 l\u1eddi l\u00e0 \u0111\u1ec3 khi\u1ebfn cho to\u00e0n b\u1ed9 m\u1ed9t qu\u1ea7n th\u1ec3 mu\u1ed7i c\u00f3 kh\u1ea3 n\u0103ng kh\u00e1ng Plasmodium, ch\u00fang ta s\u1ebd ph\u1ea3i t\u00ecm \u0111\u01b0\u1ee3c c\u00e1ch khi\u1ebfn cho c\u00e1c gene y\u1ebfu c\u1ee7a mu\u1ed7i b\u1ecb tuy\u1ec7t ch\u1ee7ng. \u0110i\u1ec1u n\u00e0y l\u00e0 r\u1ea5t kh\u00f3 kh\u0103n b\u1edfi t\u1ef7 l\u1ec7 di truy\u1ec1n th\u01b0\u1eddng ch\u1ec9 r\u01a1i v\u00e0o m\u1ee9c 50%.<\/div>\n
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\u0110\u00e2y ch\u00ednh l\u00e0 \u0111i\u1ec3m \u0111\u1ed9t ph\u00e1 c\u1ee7a UCI – c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i tr\u01b0\u1eddng \u0111\u1ea1i h\u1ecdc n\u00e0y \u0111\u00e3 t\u00ecm ra bi\u1ec7n ph\u00e1p \u0111\u1ec3 khi\u1ebfn cho gene ch\u1ed1ng Plasmodium \u0111\u01b0\u1ee3c di truy\u1ec1n sang g\u1ea7n nh\u01b0 l\u00e0 to\u00e0n b\u1ed9 c\u00e1c th\u1ebf h\u1ec7 sau c\u1ee7a gi\u1ed1ng mu\u1ed7i \u0111\u00e3 \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i gene. H\u1ecd s\u1eed d\u1ee5ng k\u1ef9 thu\u1eadt bi\u1ebfn \u0111\u1ed5i gene g\u00e2y tranh c\u00e3i CRISPR-9 \u0111\u1ec3 th\u00eam v\u00e0o 2 gene c\u00f3 kh\u1ea3 n\u0103ng ch\u1ed1ng nguy\u00ean b\u00e0o g\u00e2y s\u1ed1t r\u00e9t l\u00ean nhi\u1ec5m s\u1eafc th\u1ec3 c\u1ee7a mu\u1ed7i. B\u1eb1ng c\u00e1ch lai gi\u1ed1ng 2 con mu\u1ed7i (th\u1ebf h\u1ec7 P) \u0111\u00e3 \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i gene, gene \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i s\u1ebd c\u00f3 t\u1ef7 l\u1ec7 di truy\u1ec1n t\u1edbi 99% l\u00ean c\u00e1c th\u1ebf h\u1ec7 con c\u1ee7a ch\u00fang, gi\u00fap cho mu\u1ed7i th\u1ebf h\u1ec7 F1 c\u00f3 kh\u1ea3 n\u0103ng ch\u1ed1ng s\u1ed1t r\u00e9t.<\/div>\n
Sau khi \u0111\u01b0a lo\u00e0i mu\u1ed7i n\u00e0y v\u00e0o m\u1ed9t qu\u1ea7n th\u1ec3 mu\u1ed7i, gene \u0111\u01b0\u1ee3c bi\u1ebfn \u0111\u1ed5i s\u1ebd nhanh ch\u00f3ng di truy\u1ec1n, thay th\u1ebf to\u00e0n b\u1ed9 c\u00e1c gene y\u1ebfu kh\u00f4ng th\u1ec3 kh\u00e1ng s\u1ed1t r\u00e9t. Nghi\u00ean c\u1ee9u c\u1ee7a UCI cho bi\u1ebft h\u1ecd c\u00f3 th\u1ec3 t\u1ea1o ra m\u1ed9t qu\u1ea7n th\u1ec3 \u0111\u1ee7 l\u1edbn \u0111\u1ec3 mang v\u00e0o th\u1eed nghi\u1ec7m th\u1ef1c t\u1ebf trong v\u00f2ng d\u01b0\u1edbi 1 n\u0103m.<\/div>\n
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Tuy v\u1eady, c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u v\u1eabn c\u00f2n ph\u1ea3i v\u01b0\u1ee3t qua nhi\u1ec1u r\u00e0o c\u1ea3n v\u1ec1 \u0111\u1ea1o \u0111\u1ee9c, lu\u1eadt l\u1ec7 v\u00e0 k\u1ef9 thu\u1eadt. GS. Anothony James, b\u1ed9 m\u00f4n sinh h\u1ecdc nguy\u00ean t\u1eed c\u1ee7a UCI kh\u1eb3ng \u0111\u1ecbnh: “C\u00f4ng ngh\u1ec7 n\u00e0y s\u1ebd ch\u01b0a \u0111i \u0111\u1ebfn \u0111\u00e2u cho t\u1edbi khi khoa h\u1ecdc x\u00e3 h\u1ed9i ph\u00e1t tri\u1ec3n \u0111\u1ee7 m\u1ee9c \u0111\u1ec3 ch\u00fang t\u00f4i c\u00f3 th\u1ec3 kh\u1ed1ng ch\u1ebf n\u00f3. Ch\u00fang t\u00f4i s\u1ebd kh\u00f4ng l\u00e0m \u0111i\u1ec1u g\u00ec ngu ng\u1ed1c c\u1ea3”.<\/div>\n

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M\u1ed9t c\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u c\u1ee7a c\u00e1c nh\u00e0 khoa h\u1ecdc M\u1ef9 s\u1ebd gi\u00fap cho gene ch\u1ed1ng s\u1ed1t r\u00e9t \u0111\u01b0\u1ee3c di truy\u1ec1n r\u1ed9ng kh\u1eafp trong qu\u1ea7n th\u1ec3 mu\u1ed7i, khi\u1ebfn cho lo\u00e0i c\u00f4n tr\u00f9ng n\u00e0y m\u1ea5t kh\u1ea3 n\u0103ng l\u00e2y truy\u1ec1n c\u0103n b\u1ec7nh ch\u1ebft ng\u01b0\u1eddi tr\u00ean cho con ng\u01b0\u1eddi. Theo Engadget, m\u1ed9t nghi\u00ean c\u1ee9u m\u1edbi \u0111\u01b0\u1ee3c h\u1ee3p t\u00e1c […]\n","protected":false},"author":1,"featured_media":6298,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[87],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6750"}],"collection":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/comments?post=6750"}],"version-history":[{"count":0,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6750\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media\/6298"}],"wp:attachment":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media?parent=6750"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/categories?post=6750"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/tags?post=6750"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}