{"id":6754,"date":"2015-10-15T08:05:48","date_gmt":"2015-10-15T01:05:48","guid":{"rendered":"http:\/\/antoansinhhoc.vn\/?p=1208"},"modified":"2015-10-15T08:05:48","modified_gmt":"2015-10-15T01:05:48","slug":"giai-trinh-tu-bo-gen-con-bach-tuot","status":"publish","type":"post","link":"https:\/\/nbca.gov.vn\/giai-trinh-tu-bo-gen-con-bach-tuot\/","title":{"rendered":"Gi\u1ea3i tr\u00ecnh t\u1ef1 b\u1ed9 gen con b\u1ea1ch tu\u1ed9t"},"content":{"rendered":"
M\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 khoa h\u1ecdc qu\u1ed1c t\u1ebf v\u1eeba th\u1ef1c hi\u1ec7n th\u00e0nh c\u00f4ng gi\u1ea3i tr\u00ecnh t\u1ef1 b\u00f4 gen con b\u1ea1ch tu\u1ed9t thu\u1ed9c lo\u00e0i \u201ccommon California two-spot octopus: t\u00ean khoa h\u1ecdc l\u00e0 Octopus bimaculoides\u201d, \u0111\u00e2y l\u00e0 lo\u00e0i sinh v\u1eadt \u201ccephalopod\u201d \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c gi\u1ea3i tr\u00ecnh t\u1ef1 DNA \u0111\u1ea7y \u0111\u1ee7.<\/span><\/div>\n
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D\u1ef1 \u00e1n gi\u1ea3i tr\u00ecnh t\u1ef1 b\u1ed9 genome b\u1ea1ch tu\u1ed9t do c\u00e1c nh\u00e0 khoa h\u1ecdc c\u1ee7a \u0110H Chicago, \u0110H California, Berkeley, v\u00e0 Vi\u1ec7n Khoa h\u1ecdc v\u00e0 C\u00f4ng ngh\u1ec7 Okinawa th\u1ef1c hi\u1ec7n.\u00a0H\u1ecd kh\u00e1m ph\u00e1 \u0111\u01b0\u1ee3c nh\u1eefng kh\u00e1c bi\u1ec7t h\u1ebft s\u1ee9c \u1ea5n t\u01b0\u1ee3ng v\u1ec1 nh\u1eefng genomes c\u1ee7a b\u1ea1ch tu\u1ed9t v\u00e0 lo\u00e0i \u0111\u1ed9ng v\u1eadt kh\u00f4ng x\u01b0\u01a1ng s\u1ed1ng (invertebrates).<\/p>\n

H\u00e0ng tr\u0103m gen c\u00f3 t\u00ednh ch\u1ea5t chuy\u00ean bi\u1ec7t c\u1ee7a ri\u00eang con b\u1ea1ch tu\u1ed9t \u0111\u00e3 \u0111\u01b0\u1ee3c x\u00e1c \u0111\u1ecbnh, nhi\u1ec1u gen th\u1ec3 hi\u1ec7n c\u1ea5u tr\u00fac nh\u01b0 n\u00e3o b\u1ed9, da v\u00e0 gi\u00e1c tu. H\u1ecd d\u1ef1 \u0111o\u00e1n r\u1eb1ng b\u1ed9 genome c\u1ee7a O. bimaculoides c\u00f3 kho\u1ea3ng 2,7 tri\u1ec7u c\u1eb7p base v\u1ec1 m\u1eb7t k\u00edch th\u01b0\u1edbc genome, v\u1edbi nhi\u1ec1u \u0111o\u1ea1n ph\u00e2n t\u1eed d\u00e0i thu\u1ed9c chu\u1ed7i tr\u00ecnh t\u1ef1 l\u1eadp l\u1ea1i.<\/p>\n

C\u00e1c nh\u00e0 khoa h\u1ecdc x\u00e1c \u0111\u1ecbnh c\u00f3 h\u01a1n 33.000 gen m\u00e3 h\u00f3a protein, v\u00e0 x\u1ebfp h\u1ea1ng genome b\u1ea1ch tu\u1ed9t sau genome ng\u01b0\u1eddi v\u1ec1 \u0111\u1ed9 l\u1edbn, nh\u01b0ng l\u1ea1i ch\u1ee9a nhi\u1ec1u gen h\u01a1n. H\u1ecd cho r\u1eb1ng h\u1ea7u h\u1ebft s\u1ef1 ph\u00e1t tri\u1ec3n gen qu\u00fd trong b\u1ea1ch tu\u1ed9t c\u00f3 t\u00ednh ch\u1ea5t c\u1ee7a protocadherins, m\u1ed9t h\u1ecd gen \u0111i\u1ec1u h\u00f2a s\u1ef1 ph\u00e1t tri\u1ec3n n\u01a1 r\u00f4n v\u00e0 nh\u1eefng t\u01b0\u01a1ng t\u00e1c c\u00f3 t\u00ednh ch\u1ea5t kho\u1ea3ng h\u1eb9p gi\u1eef nh\u1eefng n\u01a1 r\u00f4n. B\u1ed9 genome c\u1ee7a b\u1ea1ch tu\u1ed9t c\u00f3 168 gen thu\u1ed9c protocadherin, g\u1ea5p 10 l\u1ea7n h\u01a1n c\u00e1c lo\u00e0i \u0111\u1ed9ng v\u1eadt kh\u00f4ng x\u01b0\u01a1ng s\u1ed1ng kh\u00e1c, v\u00e0 g\u1ea5p \u0111\u00f4i \u0111\u1ed9ng v\u1eadt c\u00f3 v\u00fa.<\/p>\n

Nh\u00f3m nghi\u00ean c\u1ee9u c\u00f2n ghi nh\u1eadn b\u1ed9 genome con b\u1ea1ch tu\u1ed9t c\u00f3 r\u1ea5t nhi\u1ec1u transposons, hay c\u00f2n g\u1ecdi l\u00e0 gen nh\u1ea3y (jumping genes). Trong khi vai tr\u00f2 c\u1ee7a b\u1ea1ch tu\u1ed9t ch\u01b0a \u0111\u01b0\u1ee3c bi\u1ebft r\u00f5 r\u00e0ng, nh\u01b0ng nh\u00f3m nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 t\u00ecm th\u1ea5y s\u1ef1 th\u1ec3 hi\u1ec7n transposon t\u0103ng \u0111\u00e1ng k\u1ec3 trong c\u00e1c m\u00f4 n\u01a1 r\u00f4n th\u1ea7n kinh.<\/p>\n<\/div>\n

<\/div>\n
Xem University of California Berkeley website v\u00e0 University of Chicago website.<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

M\u1ed9t nh\u00f3m c\u00e1c nh\u00e0 khoa h\u1ecdc qu\u1ed1c t\u1ebf v\u1eeba th\u1ef1c hi\u1ec7n th\u00e0nh c\u00f4ng gi\u1ea3i tr\u00ecnh t\u1ef1 b\u00f4 gen con b\u1ea1ch tu\u1ed9t thu\u1ed9c lo\u00e0i \u201ccommon California two-spot octopus: t\u00ean khoa h\u1ecdc l\u00e0 Octopus bimaculoides\u201d, \u0111\u00e2y l\u00e0 lo\u00e0i sinh v\u1eadt \u201ccephalopod\u201d \u0111\u1ea7u ti\u00ean \u0111\u01b0\u1ee3c gi\u1ea3i tr\u00ecnh t\u1ef1 DNA \u0111\u1ea7y \u0111\u1ee7. D\u1ef1 \u00e1n gi\u1ea3i tr\u00ecnh t\u1ef1 b\u1ed9 genome […]\n","protected":false},"author":1,"featured_media":6311,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[87],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6754"}],"collection":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/comments?post=6754"}],"version-history":[{"count":0,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6754\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media\/6311"}],"wp:attachment":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media?parent=6754"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/categories?post=6754"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/tags?post=6754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}