{"id":6761,"date":"2016-07-28T06:55:01","date_gmt":"2016-07-27T23:55:01","guid":{"rendered":"http:\/\/antoansinhhoc.vn\/?p=885"},"modified":"2016-07-28T06:55:01","modified_gmt":"2016-07-27T23:55:01","slug":"dung-hop-cac-gen-lien-quan-den-mien-dich-trong-thuc-vat","status":"publish","type":"post","link":"https:\/\/nbca.gov.vn\/dung-hop-cac-gen-lien-quan-den-mien-dich-trong-thuc-vat\/","title":{"rendered":"Dung h\u1ee3p c\u00e1c gen li\u00ean quan \u0111\u1ebfn mi\u1ec5n d\u1ecbch trong th\u1ef1c v\u1eadt"},"content":{"rendered":"
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Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1edfi c\u00e1c nh\u00e0 khoa h\u1ecdc c\u1ee7a TGAC (The Genome Analysis Centre) v\u00e0 TSL (The Sainsbury Laboratory) nh\u1eb1m t\u00ecm ki\u1ebfm c\u00e1c gen li\u00ean quan \u0111\u1ebfn mi\u1ec5n d\u1ecbch trong th\u1ef1c v\u1eadt hi\u1ec3n hoa \u0111\u1ec3 x\u00e2y d\u1ef1ng c\u00e1c b\u1ea9y ph\u00e2n t\u1eed (molecular \u2018traps’) m\u00e0 th\u1ef1c v\u1eadt s\u1eed d\u1ee5ng nh\u1eb1m ph\u00e1t hi\u1ec7n nh\u1eefng pathogens g\u00e2y h\u1ea1i ch\u00fang.<\/p>\n

\"TV<\/a><\/p>\n<\/div>\n

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M\u1ed9t t\u1eadp h\u1ecdp c\u00e1c ph\u00e2n t\u1eed receptor trong h\u1ec7 mi\u1ec5n d\u1ecbch th\u1ef1c v\u1eadt \u0111\u00e3 \u0111\u01b0\u1ee3c ng\u01b0\u1eddi ta ph\u00e2n l\u1eadp c\u00f3 t\u00ednh ch\u1ea5t th\u00f4ng tin r\u1ea5t cao v\u1ec1 t\u00ednh kh\u00e1ng b\u1ec7nh c\u1ee7a c\u00e2y tr\u1ed3ng. Ph\u00e2n t\u1eed receptor NLR (Nucleotide-binding Leucine-Rich Repeat) c\u00f3 nh\u1eefng domains c\u00f3 t\u00ednh ch\u1ea5t h\u1ee3p nh\u1ea5t m\u1ed9t c\u00e1ch t\u0103ng c\u01b0\u1eddng th\u00eam. Nh\u1eefng domains \u1ea5y ho\u1ea1t \u0111\u1ed9ng nh\u01b0 m\u1ed9t b\u1ea9y sinh h\u1ecdc (baits) \u0111\u1ed1i v\u1edbi pathogen. Ch\u00fang \u0111\u01b0\u1ee3c t\u00ecm th\u1ea5y trong c\u00e2y l\u00faa v\u00e0 c\u00e2y Arabidopsis. Ch\u00fang bi\u1ec3u hi\u1ec7n trong th\u00ed nghi\u1ec7m nh\u01b0 nh\u1eefng gen kh\u00e1ng b\u1ec7nh. Dr. Ksenia Krasileva thu\u1ed9c TGAC v\u00e0 \u0111\u1ed3ng nghi\u1ec7p c\u1ee7a c\u00f4 t\u1ea1i TSL l\u00e0 Gi\u00e1o S\u01b0 Jonathan Jones, Dr. Panagiotis Sarris \u0111\u00e3 t\u00ecm th\u1ea5y nh\u1eefng gen n\u00e0y th\u00f4ng qua nhi\u1ec1u lo\u00e0i th\u1ef1c v\u1eadt, c\u00f3 trong danh m\u1ee5c c\u00e1c c\u00e2y tr\u1ed3ng ch\u00ednh c\u1ee7a Anh Qu\u1ed1c \u0111\u00f3 l\u00e0: lu\u00faa m\u00ec, khoai t\u00e2y v\u00e0 c\u1ea3i m\u00f9 t\u1ea1t. Nh\u00f3m nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 scan 40 tr\u00ecnh t\u1ef1 b\u00f4 genome c\u1ee7a c\u00e2y tr\u1ed3ng, bao g\u1ed3m 19 lo\u00e0i th\u1ef1c v\u1eadt v\u1edbi \u0111\u1ea7y \u0111\u1ee7 n\u1ed9i dung c\u1ee7a ph\u1ed5 ph\u00e2n t\u1eed (full spectrum) NLRs \u0111\u01b0\u1ee3c h\u1ee3p nh\u1ea5t th\u00e0nh nh\u1eefng protein kh\u00e1c c\u1ee7a c\u00e2y.<\/p>\n

Nh\u00f3m nghi\u00ean c\u1ee9u \u0111\u00e3 \u0111\u00e1nh gi\u00e1 t\u00ednh ch\u1ea5t \u0111a d\u1ea1ng c\u1ee7a nh\u1eefng h\u00ecnh th\u1ee9c h\u1ee3p nh\u1ea5t \u1ea5y \u0111\u1ed1i v\u1edbi c\u00e1c domain (potential sensor domains) trong ng\u00e0nh th\u1ef1c v\u1eadt hi\u1ec3n hoa, v\u00e0 ph\u00e2n t\u00edch b\u1ed5 sung b\u1eb1ng ph\u01b0\u01a1ng ph\u00e1p th\u1ee7 c\u00f4ng tr\u00ean c\u00e2y l\u00faa m\u00ec v\u00e0 c\u00e2y c\u1ea3i (brassicas) minh ch\u1ee9ng r\u1eb1ng c\u00f3 m\u1ed9t subset c\u1ee7a nh\u1eefng m\u00f4 h\u00ecnh h\u1ee3p nh\u1ea5t (fusions) hi\u1ec3n th\u1ecb trong lo\u00e0i hoang d\u1ea1i v\u00e0 gi\u1ed1ng c\u00e2y tr\u1ed3ng.<\/p>\n<\/div>\n

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“Kh\u00e1m ph\u00e1 khoa h\u1ecdc mang t\u00ednh ch\u1ea5t \u0111\u1ed9t ph\u00e1 \u1ea5y trong cu\u1ed9c chi\u1ebfn thu\u1ed9c qu\u00e1 tr\u00ecnh ti\u1ebfn h\u00f3a gi\u1eefa c\u00e2y v\u00e0 pathogen ch\u1ec9 ra r\u1eb1ng nh\u1eefng receptor li\u00ean quan \u0111\u1ebfn mi\u1ec5n d\u1ecbch th\u1ef1c v\u1eadt mang th\u00eam nh\u1eefng protein m\u1edbi \u0111\u01b0\u1ee3c h\u00ecnh th\u00e0nh, m\u00e0 nh\u1eefng protein nh\u01b0 v\u1eady cho ph\u00e9p ch\u00fang ph\u00e1t hi\u1ec7n ra c\u00e1c pathogens v\u00e0 k\u00edch ho\u1ea1t h\u1ec7 th\u1ed1ng t\u1ef1 v\u1ec7 hi\u1ec7u qu\u1ea3 h\u01a1n. Nghi\u00ean c\u1ee9u c\u00f2n kh\u1eb3ng \u0111\u1ecbnh c\u00f3 m\u1ed9t l\u01b0\u1ee3ng r\u1ea5t l\u1edbn c\u00e1c domain mang t\u00ednh ch\u1ea5t th\u1eeba th\u00e3i (extraneous).<\/p>\n

K\u1ebft qu\u1ea3 nghi\u00ean c\u1ee9u n\u00e0y c\u00f3 th\u1ec3 gi\u00fap ch\u00fang ta c\u00f3 \u0111\u01b0\u1ee3c m\u1ed9t c\u00e1ch nh\u00ecn m\u1edbi t\u1ed1t h\u01a1n v\u1ec1 chi\u1ebfn l\u01b0\u1ee3c g\u00e2y \u0111\u1ed9c t\u00ednh c\u1ee7a nh\u1eefng vi khu\u1ea9n c\u00f3 h\u1ea1i, ch\u00fang \u0111\u00e3 s\u1eed d\u1ee5ng chi\u1ebfn l\u01b0\u1ee3c \u1ea5y g\u00e2y tr\u1ea7m tr\u1ecdng th\u00eam s\u1ef1 nhi\u1ec5m b\u1ec7nh, Dr. Sarris, t\u00e1c gi\u1ea3 ch\u00ednh c\u1ee7a nghi\u00ean c\u1ee9u n\u00e0y \u0111\u00e3 n\u00f3i .<\/p>\n<\/div>\n

<\/div>\n
Xem th\u00eam chi ti\u1ebft t\u1ea1i TGAC website.<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Nghi\u00ean c\u1ee9u \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n b\u1edfi c\u00e1c nh\u00e0 khoa h\u1ecdc c\u1ee7a TGAC (The Genome Analysis Centre) v\u00e0 TSL (The Sainsbury Laboratory) nh\u1eb1m t\u00ecm ki\u1ebfm c\u00e1c gen li\u00ean quan \u0111\u1ebfn mi\u1ec5n d\u1ecbch trong th\u1ef1c v\u1eadt hi\u1ec3n hoa \u0111\u1ec3 x\u00e2y d\u1ef1ng c\u00e1c b\u1ea9y ph\u00e2n t\u1eed (molecular \u2018traps’) m\u00e0 th\u1ef1c v\u1eadt s\u1eed d\u1ee5ng nh\u1eb1m ph\u00e1t hi\u1ec7n nh\u1eefng pathogens […]\n","protected":false},"author":1,"featured_media":5954,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[87],"tags":[],"acf":[],"_links":{"self":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6761"}],"collection":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/comments?post=6761"}],"version-history":[{"count":0,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/posts\/6761\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media\/5954"}],"wp:attachment":[{"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/media?parent=6761"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/categories?post=6761"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nbca.gov.vn\/wp-json\/wp\/v2\/tags?post=6761"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}