{"id":48426,"date":"2020-03-17T10:12:07","date_gmt":"2020-03-17T03:12:07","guid":{"rendered":"http:\/\/tcvn.gov.vn\/?p=48426"},"modified":"2020-03-17T10:12:07","modified_gmt":"2020-03-17T03:12:07","slug":"canh-bao-nguy-hiem-thuoc-giam-dau-ibuprofen-co-the-gay-hai-nghiem-trong-toi-gan","status":"publish","type":"post","link":"https:\/\/tcvn.gov.vn\/canh-bao-nguy-hiem-thuoc-giam-dau-ibuprofen-co-the-gay-hai-nghiem-trong-toi-gan\/17\/03\/2020\/","title":{"rendered":"C\u1ea3nh b\u00e1o nguy hi\u1ec3m: Thu\u1ed1c gi\u1ea3m \u0111au ibuprofen c\u00f3 th\u1ec3 g\u00e2y h\u1ea1i nghi\u00eam tr\u1ecdng t\u1edbi gan"},"content":{"rendered":"

Theo nghi\u00ean c\u1ee9u m\u1edbi \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 b\u1edfi c\u00e1c nh\u00e0 khoa h\u1ecdc M\u1ef9, thu\u1ed1c gi\u1ea3m \u0111au ibuprofen c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5 g\u00e2y \u1ea3nh h\u01b0\u1edfng nghi\u00eam tr\u1ecdng \u0111\u1ebfn gan.<\/strong><\/span><\/p>\n

Theo th\u00f4ng tin tr\u00ean t\u1edd\u00a0UCDAVIS<\/em>, ibuprofen l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c gi\u1ea3m \u0111au r\u1ebb ti\u1ec1n ph\u1ed5 bi\u1ebfn \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 gi\u1ea3m \u0111au, s\u1ed1t v\u00e0 c\u00e1c t\u00ecnh tr\u1ea1ng kh\u00f3 ch\u1ecbu kh\u00e1c. M\u1edbi \u0111\u00e2y, c\u00e1c nh\u00e0\u00a0khoa h\u1ecdc\u00a0<\/a>M\u1ef9 \u0111\u00e3 ph\u00e1t hi\u1ec7n ra r\u1eb1ng t\u00e1c d\u1ee5ng ph\u1ee5 c\u1ee7a thu\u1ed1c \u0111\u1ed1i v\u1edbi gan nghi\u00eam tr\u1ecdng h\u01a1n nhi\u1ec1u so v\u1edbi tr\u01b0\u1edbc \u0111\u00e2y. \u0110\u1ed3ng th\u1eddi,\u00a0k\u00eau g\u1ecdi kh\u00f4ng s\u1eed d\u1ee5ng ibuprofen khi kh\u00f4ng th\u1eadt s\u1ef1 c\u1ea7n thi\u1ebft.<\/span><\/p>\n

Gi\u00e1o s\u01b0 Aldrin Gomez, t\u00e1c gi\u1ea3 c\u1ee7a c\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u cho bi\u1ebft, thu\u1ed1c gi\u1ea3m \u0111au\u00a0ibuprofen\u00a0c\u00f3 th\u1ec3 g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 nghi\u00eam tr\u1ecdng, do \u0111\u00f3 trong c\u00e1c t\u1edd h\u01b0\u1edbng d\u1eabn s\u1eed d\u1ee5ng lo\u1ea1i thu\u1ed1c n\u00e0y, c\u00e1c nh\u00e0 ph\u00e2n ph\u1ed1i th\u01b0\u1eddng ghi th\u00eam th\u00f4ng tin thu\u1ed1c \u0111\u01b0\u1ee3c d\u00f9ng trong m\u1ed9t s\u1ed1 tr\u01b0\u1eddng h\u1ee3p nh\u1ea5t \u0111\u1ecbnh.\u00a0\u00d4ng Aldrin Gomez cho bi\u1ebft th\u00eam, nh\u00f3m c\u1ee7a \u00f4ng \u0111\u00e3 ti\u1ebfn h\u00e0nh th\u00ed nghi\u1ec7m tr\u00ean c\u00e1c m\u00f4 h\u00ecnh chu\u1ed9t v\u00e0 h\u00e0ng ng\u00e0y \u0111\u00e3 cho ch\u00fang m\u1ed9t li\u1ec1u thu\u1ed1c (kho\u1ea3ng 400 mg m\u1ed7i ng\u00e0y). Sau \u0111\u00f3, h\u1ecd \u0111\u00e3 s\u1eed d\u1ee5ng ph\u00e9p quang ph\u1ed5 kh\u1ed1i \u0111\u1ec3 ph\u00e2n t\u00edch t\u1ea5t c\u1ea3 c\u00e1c con \u0111\u01b0\u1eddng trao \u0111\u1ed5i ch\u1ea5t trong c\u00e1c t\u1ebf b\u00e0o gan.<\/span><\/p>\n

K\u1ebft qu\u1ea3 cho th\u1ea5y, thu\u1ed1c gi\u1ea3m \u0111au Ibuprofen g\u00e2y ra nhi\u1ec1u thay \u0111\u1ed5i h\u01a1n trong bi\u1ec3u hi\u1ec7n protein \u1edf gan so v\u1edbi d\u1ef1 ki\u1ebfn. T\u00e1c \u0111\u1ed9ng c\u1ee7a ibuprofen d\u1eabn \u0111\u1ebfn nh\u1eefng thay \u0111\u1ed5i trong ho\u1ea1t \u0111\u1ed9ng c\u1ee7a h\u01a1n 300 protein. \u00cdt nh\u1ea5t 34 con \u0111\u01b0\u1eddng trao \u0111\u1ed5i ch\u1ea5t \u1edf chu\u1ed9t \u0111\u1ef1c b\u1ecb suy y\u1ebfu. Trong s\u1ed1 \u0111\u00f3 c\u00f3 nh\u1eefng con \u0111\u01b0\u1eddng li\u00ean quan \u0111\u1ebfn qu\u00e1 tr\u00ecnh chuy\u1ec3n h\u00f3a axit amin, vitamin, hormone.<\/span><\/p>\n

C\u0169ng theo nh\u1eadn \u0111\u1ecbnh c\u1ee7a c\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u, \u1edf nam v\u00e0 n\u1eef th\u00ec t\u00e1c d\u1ee5ng c\u1ee7a thu\u1ed1c tr\u00ean c\u00f3 m\u1ee9c \u0111\u1ed9 \u1ea3nh h\u01b0\u1edfng kh\u00e1c nhau. V\u00ed d\u1ee5, \u1edf n\u1eef gi\u1edbi, thu\u1ed1c l\u00e0m t\u0103ng ho\u1ea1t \u0111\u1ed9ng c\u1ee7a cytochrom P450 (h\u1ec7 th\u1ed1ng enzym ch\u1ecbu tr\u00e1ch nhi\u1ec7m cho s\u1ef1 ph\u00e2n h\u1ee7y c\u1ee7a thu\u1ed1c trong c\u01a1 th\u1ec3). \u1ede nam gi\u1edbi, ho\u1ea1t t\u00ednh \u0111\u00f3 s\u1ebd b\u1ecb gi\u1ea3m \u0111i. \u0110i\u1ec1u n\u00e0y c\u00f3 ngh\u0129a l\u00e0 c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c d\u00f9ng v\u1edbi ibuprofen c\u00f3 th\u1ec3 t\u1ed3n t\u1ea1i l\u00e2u h\u01a1n trong c\u01a1 th\u1ec3 c\u1ee7a nam gi\u1edbi.<\/span><\/p>\n

\"\"<\/span><\/p>\n

\u00a0Thu\u1ed1c gi\u1ea3m \u0111au\u00a0Ibuprofen c\u00f3 th\u1ec3 g\u00e2y \u1ea3nh h\u01b0\u1edfng nghi\u00eam tr\u1ecdng \u0111\u1ebfn gan<\/span><\/strong><\/p>\n<\/div>\n

Tr\u01b0\u1edbc \u0111\u00f3, li\u00ean quan \u0111\u1ebfn nh\u1eefng \u1ea3nh h\u01b0\u1edfng ti\u00eau c\u1ef1c c\u1ee7a\u00a0ibuprofen \u0111\u1ebfn c\u00e1c c\u01a1 quan trong c\u01a1 th\u1ec3 ng\u01b0\u1eddi, c\u00e1c chuy\u00ean gia thu\u1ed9c tr\u01b0\u1eddng \u0110\u1ea1i h\u1ecdc Copenhagen (\u0110an M\u1ea1ch) cho bi\u1ebft, ibuprofen c\u0169ng nh\u01b0 c\u00e1c lo\u1ea1i thu\u1ed1c gi\u1ea3m \u0111au ch\u1ed1ng vi\u00eam kh\u00f4ng ch\u1ee9a steroid (NSAID) kh\u00e1c c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 b\u1ecb ng\u01b0ng tim.\u00a0Ng\u1eebng tim c\u00f2n g\u1ecdi l\u00e0 ng\u01b0ng tim ph\u1ed5i ho\u1eb7c ng\u1eebng tu\u1ea7n ho\u00e0n l\u00e0 ch\u1ea5m d\u1ee9t s\u1ef1 l\u01b0u th\u00f4ng b\u00ecnh th\u01b0\u1eddng c\u1ee7a m\u00e1u do tim ng\u1eebng \u0111\u1eadp. Hi\u1ec7n t\u01b0\u1ee3ng c\u01a1 tim ng\u1eebng co b\u00f3p k\u00e9o d\u00e0i \u00edt nh\u1ea5t 60 gi\u00e2y l\u00e0m cho tu\u1ea7n ho\u00e0n b\u1ecb t\u00ea li\u1ec7t. Ng\u1eebng h\u00f4 h\u1ea5p b\u1eaft \u0111\u1ea7u kho\u1ea3ng 20 \u2013 60 gi\u00e2y sau ng\u1eebng tim.<\/span><\/p>\n

C\u1ee5 th\u1ec3, theo nghi\u00ean c\u1ee9u c\u1ee7a c\u00e1c nh\u00e0 khoa h\u1ecdc, ibuprofen l\u00e0m t\u0103ng nguy c\u01a1 b\u1ecb \u0111au tim l\u00ean 31%. Ibuprofen l\u00e0 thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid, d\u1eabn xu\u1ea5t t\u1eeb acid propionic. Gi\u1ed1ng nh\u01b0 c\u00e1c thu\u1ed1c ch\u1ed1ng vi\u00eam kh\u00f4ng steroid kh\u00e1c, ibuprofen c\u00f3 t\u00e1c d\u1ee5ng gi\u1ea3m \u0111au, h\u1ea1 s\u1ed1t v\u00e0 ch\u1ed1ng vi\u00eam.<\/span><\/p>\n

Ibuprofen \u0111\u01b0\u1ee3c d\u00f9ng \u0111\u1ec3 h\u1ea1 s\u1ed1t v\u00e0 \u0111i\u1ec1u tr\u1ecb \u0111au g\u00e2y ra b\u1edfi c\u00e1c b\u1ec7nh nh\u01b0 \u0111au \u0111\u1ea7u, \u0111au r\u0103ng, \u0111au l\u01b0ng, vi\u00eam kh\u1edbp, \u0111au b\u1ee5ng kinh ho\u1eb7c \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb vi\u00eam nhi\u1ec5m. Gunnar Gislason, t\u00e1c gi\u1ea3 c\u1ee7a nghi\u00ean c\u1ee9u cho bi\u1ebft: \u201cC\u00e1c lo\u1ea1i thu\u1ed1c gi\u1ea3m \u0111au ch\u1ed1ng vi\u00eam kh\u00f4ng ch\u1ee9a steroid (NSAID) kh\u00f4ng ph\u1ea3i l\u00e0 v\u00f4 h\u1ea1i. M\u1ecdi ng\u01b0\u1eddi n\u00ean s\u1eed d\u1ee5ng thu\u1ed1c gi\u1ea3m \u0111au theo k\u00ea \u0111\u01a1n c\u1ee7a b\u00e1c s\u0129 v\u1edbi li\u1ec1u l\u01b0\u1ee3ng h\u1ee3p l\u00ed \u0111\u1ec3 tr\u00e1nh c\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5 c\u00f3 th\u1ec3 x\u1ea3y ra.\u201d<\/span><\/p>\n

B\u1ea3o L\u00e2m<\/strong>\u00a0(Theo UCDAVIS)<\/em><\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Theo nghi\u00ean c\u1ee9u m\u1edbi \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1 b\u1edfi c\u00e1c nh\u00e0 khoa h\u1ecdc M\u1ef9, thu\u1ed1c gi\u1ea3m \u0111au ibuprofen c\u00f3 t\u00e1c d\u1ee5ng ph\u1ee5 g\u00e2y \u1ea3nh h\u01b0\u1edfng nghi\u00eam tr\u1ecdng \u0111\u1ebfn gan. Theo th\u00f4ng tin tr\u00ean t\u1edd\u00a0UCDAVIS, ibuprofen l\u00e0 m\u1ed9t lo\u1ea1i thu\u1ed1c gi\u1ea3m \u0111au r\u1ebb ti\u1ec1n ph\u1ed5 bi\u1ebfn \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111\u1ec3 gi\u1ea3m \u0111au, s\u1ed1t v\u00e0 c\u00e1c t\u00ecnh tr\u1ea1ng […]<\/p>\n","protected":false},"author":5,"featured_media":48427,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[66],"tags":[],"acf":{"linh-vuc":"C\u00e1c l\u0129nh v\u1ef1c kh\u00e1c"},"_links":{"self":[{"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/posts\/48426"}],"collection":[{"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/comments?post=48426"}],"version-history":[{"count":0,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/posts\/48426\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/media\/48427"}],"wp:attachment":[{"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/media?parent=48426"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/categories?post=48426"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/tags?post=48426"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}