{"id":59086,"date":"2021-07-21T14:58:42","date_gmt":"2021-07-21T07:58:42","guid":{"rendered":"http:\/\/tcvn.gov.vn\/?p=59086"},"modified":"2021-07-21T14:58:42","modified_gmt":"2021-07-21T07:58:42","slug":"canh-bao-thuoc-khang-sinh-azithromycin-khong-hieu-qua-voi-benh-nhan-covid-19","status":"publish","type":"post","link":"https:\/\/tcvn.gov.vn\/canh-bao-thuoc-khang-sinh-azithromycin-khong-hieu-qua-voi-benh-nhan-covid-19\/21\/07\/2021\/","title":{"rendered":"C\u1ea3nh b\u00e1o – thu\u1ed1c kh\u00e1ng sinh azithromycin kh\u00f4ng hi\u1ec7u qu\u1ea3 v\u1edbi b\u1ec7nh nh\u00e2n COVID-19"},"content":{"rendered":"

Nghi\u00ean c\u1ee9u m\u1edbi t\u1ea1i M\u1ef9 cho th\u1ea5y, thu\u1ed1c kh\u00e1ng sinh azithromycin kh\u00f4ng hi\u1ec7u qu\u1ea3 h\u01a1n gi\u1ea3 d\u01b0\u1ee3c trong vi\u1ec7c ng\u0103n ng\u1eeba c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a COVID-19.<\/strong><\/span><\/p>\n

Thu\u1ed1c kh\u00e1ng sinh azithromycin- m\u1ed9t lo\u1ea1i kh\u00e1ng sinh ph\u1ed5 r\u1ed9ng, \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n nh\u01b0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb COVID-19 cho b\u1ec7nh nh\u00e2n ngo\u1ea1i tr\u00fa \u1edf M\u1ef9. Tuy nhi\u00ean nghi\u00ean c\u1ee9u m\u1edbi cho th\u1ea5y, thu\u1ed1c kh\u00f4ng mang l\u1ea1i hi\u1ec7u qu\u1ea3.<\/span><\/p>\n

Nghi\u00ean c\u1ee9u m\u1edbi \u0111\u00e2y c\u1ee7a UC San Francisco \u0111\u00e3 ch\u1ec9 ra r\u1eb1ng kh\u00e1ng sinh azithromycin kh\u00f4ng hi\u1ec7u qu\u1ea3 h\u01a1n gi\u1ea3 d\u01b0\u1ee3c trong vi\u1ec7c ng\u0103n ng\u1eeba c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a COVID-19 \u1edf nh\u1eefng b\u1ec7nh nh\u00e2n \u0111i\u1ec1u tr\u1ecb ngo\u1ea1i tr\u00fa, th\u1eadm ch\u00ed c\u00f3 th\u1ec3 l\u00e0m t\u0103ng nguy c\u01a1 nh\u1eadp vi\u1ec7n.<\/span><\/p>\n

T\u00e1c gi\u1ea3 ch\u00ednh TS. Catherine E. Oldenburg cho bi\u1ebft: \u201cPh\u00e1t hi\u1ec7n n\u00e0y kh\u00f4ng \u1ee7ng h\u1ed9 vi\u1ec7c s\u1eed d\u1ee5ng azithromycin th\u01b0\u1eddng quy cho b\u1ec7nh nh\u00e2n ngo\u1ea1i tr\u00fa nhi\u1ec5m SARS-CoV-2.\u201d<\/span><\/p>\n

\"\"<\/span><\/p>\n

\n
\n

Thu\u1ed1c kh\u00e1ng sinh azithromycin kh\u00f4ng mang l\u1ea1i hi\u1ec7u qu\u1ea3 trong \u0111i\u1ec1u tr\u1ecb Covid-19. \u1ea2nh:\u00a0Sciencedaily<\/strong><\/span><\/p>\n

Azithromycin, m\u1ed9t lo\u1ea1i kh\u00e1ng sinh ph\u1ed5 r\u1ed9ng, \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n r\u1ed9ng r\u00e3i nh\u01b0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb COVID-19 \u1edf M\u1ef9. Thu\u1ed1c c\u00f3 \u0111\u1eb7c t\u00ednh ch\u1ed1ng vi\u00eam v\u00e0 \u0111\u01b0\u1ee3c \u0111\u1ec1 xu\u1ea5t \u0111\u1ec3 ng\u0103n ch\u1eb7n s\u1ef1 ti\u1ebfn tri\u1ec3n c\u1ee7a b\u1ec7nh n\u1ebfu \u0111\u01b0\u1ee3c \u0111i\u1ec1u tr\u1ecb s\u1edbm.<\/span><\/p>\n

Nghi\u00ean c\u1ee9u bao g\u1ed3m 263 ng\u01b0\u1eddi tham gia, t\u1ea5t c\u1ea3 \u0111\u1ec1u c\u00f3 k\u1ebft qu\u1ea3 d\u01b0\u01a1ng t\u00ednh v\u1edbi SARS-CoV-2 trong v\u00f2ng 7 ng\u00e0y tr\u01b0\u1edbc khi tham gia nghi\u00ean c\u1ee9u, nh\u01b0ng kh\u00f4ng ph\u1ea3i nh\u1eadp vi\u1ec7n \u0111i\u1ec1u tr\u1ecb. Trong m\u1ed9t qu\u00e1 tr\u00ecnh l\u1ef1a ch\u1ecdn ng\u1eabu nhi\u00ean, 171 ng\u01b0\u1eddi tham gia nh\u1eadn \u0111\u01b0\u1ee3c m\u1ed9t li\u1ec1u azithromycin u\u1ed1ng 1,2 gam v\u00e0 92 ng\u01b0\u1eddi nh\u1eadn \u0111\u01b0\u1ee3c m\u1ed9t lo\u1ea1i gi\u1ea3 d\u01b0\u1ee3c gi\u1ed1ng h\u1ec7t nhau.<\/span><\/p>\n

V\u00e0o ng\u00e0y th\u1ee9 14 c\u1ee7a nghi\u00ean c\u1ee9u, 50% s\u1ed1 ng\u01b0\u1eddi tham gia v\u1eabn kh\u00f4ng c\u00f3 tri\u1ec7u ch\u1ee9ng \u1edf c\u1ea3 hai nh\u00f3m. \u0110\u1ebfn ng\u00e0y 21, n\u0103m trong s\u1ed1 nh\u1eefng ng\u01b0\u1eddi tham gia nh\u1eadn azithromycin \u0111\u00e3 ph\u1ea3i nh\u1eadp vi\u1ec7n v\u1edbi c\u00e1c tri\u1ec7u ch\u1ee9ng nghi\u00eam tr\u1ecdng c\u1ee7a COVID-19 v\u00e0 kh\u00f4ng ai trong nh\u00f3m d\u00f9ng gi\u1ea3 d\u01b0\u1ee3c ph\u1ea3i nh\u1eadp vi\u1ec7n.<\/span><\/p>\n

C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u k\u1ebft lu\u1eadn r\u1eb1ng \u0111i\u1ec1u tr\u1ecb b\u1eb1ng m\u1ed9t li\u1ec1u azithromycin duy nh\u1ea5t so v\u1edbi gi\u1ea3 d\u01b0\u1ee3c kh\u00f4ng mang l\u1ea1i hi\u1ec7u qu\u1ea3 cao h\u01a1n.<\/span><\/p>\n

Theo TS Oldenburg, h\u1ea7u h\u1ebft c\u00e1c th\u1eed nghi\u1ec7m \u0111\u01b0\u1ee3c th\u1ef1c hi\u1ec7n cho \u0111\u1ebfn nay v\u1edbi azithromycin \u0111\u1ec1u t\u1eadp trung v\u00e0o nh\u1eefng b\u1ec7nh nh\u00e2n nh\u1eadp vi\u1ec7n m\u1eafc b\u1ec7nh kh\u00e1 n\u1eb7ng. Nghi\u00ean c\u1ee9u c\u1ee7a ch\u00fang t\u00f4i l\u00e0 m\u1ed9t trong nh\u1eefng nghi\u00ean c\u1ee9u \u0111\u1ea7u ti\u00ean c\u00f3 \u0111\u1ed1i ch\u1ee9ng v\u1edbi gi\u1ea3 d\u01b0\u1ee3c cho th\u1ea5y azithromycin kh\u00f4ng c\u00f3 vai tr\u00f2 g\u00ec \u0111\u1ed1i v\u1edbi b\u1ec7nh nh\u00e2n ngo\u1ea1i tr\u00fa”.<\/span><\/p>\n

Li\u00ean quan t\u1edbi thu\u1ed1c \u0111i\u1ec1u tr\u1ecb COVID-19, m\u1edbi \u0111\u00e2y Ch\u00ednh ph\u1ee7 M\u1ef9 \u0111\u00e3 \u0111\u1ea7u t\u01b0 h\u00e0ng t\u1ef7 USD v\u00e0o thu\u1ed1c u\u1ed1ng ch\u1eefa Covid-19 \u0111\u1ec3 ng\u0103n ch\u1eb7n virus v\u1ec1 l\u00e2u d\u00e0i, c\u1ee9u s\u1ed1ng th\u00eam nhi\u1ec1u ng\u01b0\u1eddi trong t\u01b0\u01a1ng lai.<\/span><\/p>\n

Tr\u01b0\u1edbc \u0111\u00f3 M\u1ef9 chi h\u01a1n 18 t\u1ef7 USD t\u00e0i tr\u1ee3 c\u00e1c c\u00f4ng ty nghi\u00ean c\u1ee9u vaccine\u00a0COVID-19, thu l\u1ea1i 5 lo\u1ea1i vaccine hi\u1ec7u qu\u1ea3 cao trong th\u1eddi gian k\u1ef7 l\u1ee5c. Hi\u1ec7n Ch\u00ednh ph\u1ee7 n\u01b0\u1edbc n\u00e0y \u0111\u00e3 r\u00f3t h\u01a1n 3 t\u1ef7 USD cho m\u1ed9t l\u0129nh v\u1ef1c b\u1ecb b\u1ecf qu\u00ean: Ph\u00e1t tri\u1ec3n thu\u1ed1c u\u1ed1ng \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb b\u1ec7nh nh\u00e2n trong giai \u0111o\u1ea1n \u0111\u1ea7u.<\/span><\/p>\n

Ch\u01b0\u01a1ng tr\u00ecnh m\u1edbi c\u00f3 t\u00ean g\u1ecdi Chi\u1ebfn l\u01b0\u1ee3c Ph\u00e1t tri\u1ec3n ch\u1ed1ng\u00a0COVID-19, \u0111\u01b0\u1ee3c B\u1ed9 Y t\u1ebf v\u00e0 D\u1ecbch v\u1ee5 Nh\u00e2n sinh c\u00f4ng b\u1ed1 h\u1ed3i th\u00e1ng 6. M\u1ee5c ti\u00eau l\u00e0 \u0111\u1ea9y nhanh qu\u00e1 tr\u00ecnh th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng c\u1ee7a m\u1ed9t s\u1ed1 lo\u1ea1i thu\u1ed1c tri\u1ec3n v\u1ecdng. N\u1ebfu m\u1ecdi vi\u1ec7c su\u00f4n s\u1ebb, lo\u1ea1i thu\u1ed1c \u0111\u1ea7u ti\u00ean s\u1ebd ra m\u1eaft cu\u1ed1i n\u0103m nay.<\/span><\/p>\n

Theo ti\u1ebfn s\u0129 David Kessler, Gi\u00e1m \u0111\u1ed1c khoa h\u1ecdc \u0111\u1ed9i \u0111\u1eb7c nhi\u1ec7m\u00a0COVID-19\u00a0c\u1ee7a T\u1ed5ng th\u1ed1ng Joe Biden, Ch\u00ednh ph\u1ee7 c\u00f3 th\u1ec3 \u0111\u01b0a ra th\u1ecfa thu\u1eadn t\u01b0\u01a1ng t\u1ef1 v\u1edbi c\u00e1c thu\u1ed1c kh\u00e1ng virus kh\u00e1c \u0111ang trong th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng. Hi\u1ec7n t\u1ea1i, lo\u1ea1i thu\u1ed1c kh\u00e1ng virus c\u00f3 t\u00ean Molnupinavir c\u1ee7a M\u1ef9 \u0111ang l\u00e0 \u1ee9ng vi\u00ean ti\u1ec1m n\u0103ng nh\u1ea5t.<\/span><\/p>\n

Thu\u1ed1c Molnupinavir \u0111\u01b0\u1ee3c ph\u00e1t tri\u1ec3n b\u1edfi s\u1ef1 h\u1ee3p t\u00e1c gi\u1eefa 2 c\u00f4ng ty Rigibel (\u0110\u1ee9c) v\u00e0 Merk (M\u1ef9). Th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n 1 v\u00e0 giai \u0111o\u1ea1n 2 \u0111\u00e3 ho\u00e0n t\u1ea5t v\u1edbi hi\u1ec7u qu\u1ea3 100% tr\u00ean c\u00e1c b\u1ec7nh nh\u00e2n Covid-19. Sau 5 ng\u00e0y, t\u1ea3i l\u01b0\u1ee3ng virus c\u1ee7a b\u1ec7nh nh\u00e2n xu\u1ed1ng th\u1ea5p \u0111\u1ebfn ng\u01b0\u1ee1ng kh\u00f4ng l\u00e2y lan.<\/span><\/p>\n

Nghi\u00ean c\u1ee9u th\u1eed nghi\u1ec7m l\u00e2m s\u00e0ng giai \u0111o\u1ea1n 3 c\u0169ng g\u1ea7n \u0111i \u0111\u1ebfn ch\u1eb7ng cu\u1ed1i v\u1edbi hi\u1ec7u qu\u1ea3 r\u1ea5t t\u1ed1t, d\u1ef1 ki\u1ebfn s\u1ebd c\u00f3 k\u1ebft qu\u1ea3 ngay trong m\u00f9a thu n\u0103m nay. N\u1ebfu qu\u00e1 tr\u00ecnh nghi\u00ean c\u1ee9u su\u00f4n s\u1ebb, thu\u1ed1c Molnupinavir s\u1ebd \u0111\u01b0\u1ee3c \u0111\u01b0a ra th\u1ecb tr\u01b0\u1eddng trong 4-5 th\u00e1ng t\u1edbi.<\/span><\/p>\n

Lo\u1ea1i thu\u1ed1c n\u00e0y \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u d\u1ef1a tr\u00ean thu\u1ed1c g\u1ed1c ch\u1ed1ng l\u1ea1i virus c\u00fam, c\u00f3 t\u00e1c d\u1ee5ng \u1ee9c ch\u1ebf s\u1ef1 sao ch\u00e9p c\u1ee7a c\u00e1c virus RNA trong \u0111\u00f3 c\u00f3 SARS-CoV-2 khi\u1ebfn virus kh\u00f4ng nh\u00e2n l\u00ean v\u00e0 b\u1ecb \u0111\u00e0o th\u1ea3i r\u1ea5t nhanh, gi\u00fap b\u1ec7nh nh\u00e2n kh\u1ecfi b\u1ec7nh. \u0110\u1eb7c bi\u1ec7t, thu\u1ed1c c\u00f3 r\u1ea5t \u00edt t\u00e1c d\u1ee5ng ph\u1ee5, ph\u1ed5 bi\u1ebfn l\u00e0 nh\u1ee9c \u0111\u1ea7u, m\u1ea5t ng\u1ee7.<\/span><\/p>\n

Molnupinavir s\u1eed d\u1ee5ng d\u1ec5 d\u00e0ng qua \u0111\u01b0\u1eddng u\u1ed1ng, \u0111i\u1ec1u tr\u1ecb c\u00e1c b\u1ec7nh nh\u00e2n nhi\u1ec5m SARS-CoV-2 giai \u0111o\u1ea1n \u0111\u1ea7u. Theo \u0111\u00f3, m\u1ed7i b\u1ec7nh nh\u00e2n s\u1ebd u\u1ed1ng 2 li\u1ec1u m\u1ed7i ng\u00e0y v\u00e0 duy tr\u00ec trong 5 ng\u00e0y ngay t\u1ea1i nh\u00e0.\u00a0N\u1ebfu nghi\u00ean c\u1ee9u pha 3 th\u00e0nh c\u00f4ng, trong t\u01b0\u01a1ng lai vi\u1ec7c \u0111i\u1ec1u tr\u1ecb SARS-CoV-2 s\u1ebd gi\u1ed1ng nh\u01b0 \u0111i\u1ec1u tr\u1ecb c\u00e1c lo\u1ea1i c\u00fam kh\u00e1c.<\/span><\/p>\n

Hi\u1ec7n t\u1ea1i, Ch\u00ednh ph\u1ee7 M\u1ef9 \u0111\u00e3 chi kho\u1ea3ng 1,2 t\u1ef7 USD \u0111\u1ec3 mua 1,7 tri\u1ec7u li\u1ec7u tr\u00ecnh thu\u1ed1c Molnupiravir s\u1eed d\u1ee5ng cho c\u00e1c b\u1ec7nh nh\u00e2n Covid-19. N\u1ebfu k\u1ebft qu\u1ea3 th\u00e0nh c\u00f4ng, FDA c\u1ee7a M\u1ef9 s\u1ebd c\u1ea5p ph\u00e9p cho lo\u1ea1i thu\u1ed1c n\u00e0y.<\/span><\/p>\n

An D\u01b0\u01a1ng<\/strong>\u00a0(T\/h)<\/span><\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Nghi\u00ean c\u1ee9u m\u1edbi t\u1ea1i M\u1ef9 cho th\u1ea5y, thu\u1ed1c kh\u00e1ng sinh azithromycin kh\u00f4ng hi\u1ec7u qu\u1ea3 h\u01a1n gi\u1ea3 d\u01b0\u1ee3c trong vi\u1ec7c ng\u0103n ng\u1eeba c\u00e1c tri\u1ec7u ch\u1ee9ng c\u1ee7a COVID-19. Thu\u1ed1c kh\u00e1ng sinh azithromycin- m\u1ed9t lo\u1ea1i kh\u00e1ng sinh ph\u1ed5 r\u1ed9ng, \u0111\u01b0\u1ee3c k\u00ea \u0111\u01a1n nh\u01b0 m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb COVID-19 cho b\u1ec7nh nh\u00e2n ngo\u1ea1i tr\u00fa \u1edf M\u1ef9. Tuy nhi\u00ean […]<\/p>\n","protected":false},"author":5,"featured_media":59088,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[66],"tags":[],"acf":{"linh-vuc":"C\u00e1c l\u0129nh v\u1ef1c kh\u00e1c"},"_links":{"self":[{"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/posts\/59086"}],"collection":[{"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/comments?post=59086"}],"version-history":[{"count":0,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/posts\/59086\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/media\/59088"}],"wp:attachment":[{"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/media?parent=59086"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/categories?post=59086"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/tags?post=59086"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}