{"id":71821,"date":"2022-12-15T14:00:20","date_gmt":"2022-12-15T07:00:20","guid":{"rendered":"https:\/\/tcvn.gov.vn\/?p=71821"},"modified":"2022-12-15T14:00:22","modified_gmt":"2022-12-15T07:00:22","slug":"kiem-soat-luong-thuoc-hap-thu-trong-co-the-nho-mieng-cam-bien-sinh-hoc","status":"publish","type":"post","link":"https:\/\/tcvn.gov.vn\/kiem-soat-luong-thuoc-hap-thu-trong-co-the-nho-mieng-cam-bien-sinh-hoc\/15\/12\/2022\/","title":{"rendered":"Ki\u1ec3m so\u00e1t l\u01b0\u1ee3ng thu\u1ed1c h\u1ea5p th\u1ee5 trong c\u01a1 th\u1ec3 nh\u1edd mi\u1ebfng c\u1ea3m bi\u1ebfn sinh h\u1ecdc"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 10pt;\">C\u00e1c b\u00e1c s\u0129 c\u00f3 th\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c l\u01b0\u1ee3ng thu\u1ed1c h\u1ea5p th\u1ee5 trong c\u01a1 th\u1ec3 nh\u1edd mi\u1ebfng d\u00e1n c\u1ea3m bi\u1ebfn sinh h\u1ecdc, \u0111\u1eb7c bi\u1ec7t l\u00e0 c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u1ec7nh n\u1eb7ng.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 10pt;\">V\u1edbi nhi\u1ec1u lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m tr\u00f9ng v\u00e0 ung th\u01b0, gi\u1eefa li\u1ec1u thu\u1ed1c ch\u1eefa b\u1ec7nh v\u00e0 li\u1ec1u g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 nguy hi\u1ec3m ch\u1ec9 c\u00e1ch nhau m\u1ed9t ranh gi\u1edbi mong manh. Tuy nhi\u00ean, \u0111\u1ec3 d\u1ef1 \u0111o\u00e1n ranh gi\u1edbi n\u00e0y l\u1ea1i l\u00e0 m\u1ed9t th\u00e1ch th\u1ee9c. B\u1edfi nh\u1eefng ng\u01b0\u1eddi kh\u00e1c nhau ph\u1ea3n \u1ee9ng kh\u00e1c nhau v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c, ngay c\u1ea3 v\u1edbi c\u00f9ng m\u1ed9t li\u1ec1u l\u01b0\u1ee3ng. Do \u0111\u00f3, c\u00e1c nh\u00e0 khoa h\u1ecdc cho r\u1eb1ng c\u1ea7n t\u00ecm m\u1ed9t ph\u01b0\u01a1ng ph\u00e1p n\u00e0o \u0111\u00f3 \u0111\u1ec3 d\u1ef1 \u0111o\u00e1n ch\u00ednh x\u00e1c li\u1ec1u l\u01b0\u1ee3ng thu\u1ed1c \u0111\u01b0a v\u00e0o c\u01a1 th\u1ec3.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 10pt;\">Hi\u1ec7n t\u1ea1i, c\u00e1c b\u00e1c s\u0129 c\u00f3 th\u1ec3 hi\u1ec7u ch\u1ec9nh l\u01b0\u1ee3ng thu\u1ed1c b\u1eb1ng c\u00e1ch l\u1ea5y m\u00e1u \u0111\u1ec3 ki\u1ec3m tra l\u01b0\u1ee3ng thu\u1ed1c trong c\u01a1 th\u1ec3 b\u1ec7nh nh\u00e2n. Nh\u01b0ng nh\u1eefng x\u00e9t nghi\u1ec7m \u0111\u00f3 th\u01b0\u1eddng m\u1ea5t th\u1eddi gian \u00edt nh\u1ea5t m\u1ed9t ng\u00e0y \u0111\u1ec3 c\u00f3 k\u1ebft qu\u1ea3 v\u00e0 ch\u1ec9 \u0111o li\u1ec1u l\u01b0\u1ee3ng thu\u1ed1c t\u1ea1i m\u1ed9t ho\u1eb7c hai th\u1eddi \u0111i\u1ec3m. V\u00ec v\u1eady, k\u1ebft qu\u1ea3 x\u00e9t nghi\u1ec7m m\u00e1u kh\u00f4ng gi\u00fap \u00edch nhi\u1ec1u khi x\u00e1c \u0111\u1ecbnh c\u00e1ch \u0111i\u1ec1u ch\u1ec9nh l\u01b0\u1ee3ng li\u1ec1u l\u01b0\u1ee3ng thu\u1ed1c trong th\u1ef1c t\u1ebf.<\/span><\/p>\n<div class=\"photo_detail\" style=\"text-align: justify;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 10pt;\"><img loading=\"lazy\" class=\"aligncenter\" title=\"\" src=\"http:\/\/media.vietq.vn\/files\/ngoyenhoa\/2022\/12\/12\/38.jpg\" alt=\"\" width=\"576\" height=\"383\" \/><\/span><\/p>\n<h2 class=\"caption_image\" style=\"text-align: center;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 10pt;\">Mi\u1ebfng c\u1ea3m bi\u1ebfn sinh h\u1ecdc c\u00f3 th\u1ec3 x\u00e1c \u0111\u1ecbnh l\u01b0\u1ee3ng thu\u1ed1c trong c\u01a1 th\u1ec3 ng\u01b0\u1eddi b\u1ec7nh\u00a0<\/span><\/h2>\n<\/div>\n<p style=\"text-align: justify;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 10pt;\">M\u1edbi \u0111\u00e2y, nh\u00f3m nghi\u00ean c\u1ee9u t\u1ea1i \u0110\u1ea1i h\u1ecdc California (Los Angeles, Hoa K\u1ef3) \u0111\u00e3 ph\u00e1t tri\u1ec3n m\u1ed9t mi\u1ebfng d\u00e1n \u0111eo, s\u1eed d\u1ee5ng kim si\u00eau nh\u1ecf c\u00f3 th\u1ec3 ph\u00e2n t\u00edch ch\u1ea5t l\u1ecfng gi\u1eefa c\u00e1c t\u1ebf b\u00e0o d\u01b0\u1edbi da, t\u1eeb \u0111\u00f3 gi\u00fap qu\u1ea3n l\u00fd li\u1ec1u l\u01b0\u1ee3ng thu\u1ed1c ch\u00ednh x\u00e1c.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 10pt;\">Mi\u1ebfng d\u00e1n c\u1ea3m bi\u1ebfn c\u00f3 \u0111\u01b0\u1eddng k\u00ednh kho\u1ea3ng 1\/4 inch (6,35 mm), \u0111o l\u01b0\u1ee3ng thu\u1ed1c, s\u1eed d\u1ee5ng c\u00e1c chu\u1ed7i DNA \u0111\u01b0\u1ee3c thi\u1ebft k\u1ebf s\u1eb5n c\u00f3 t\u00ean l\u00e0 aptamer. Khi aptamer ti\u1ebfp x\u00fac v\u1edbi m\u1ed9t ph\u00e2n t\u1eed thu\u1ed1c c\u1ee5 th\u1ec3, n\u00f3 s\u1ebd thay \u0111\u1ed5i h\u00ecnh d\u1ea1ng. M\u1ed9t \u0111\u1ea7u c\u1ee7a aptamer \u0111\u01b0\u1ee3c neo v\u00e0o c\u00e1c h\u1ea1t nano v\u00e0ng l\u1eafng \u0111\u1ecdng tr\u00ean kim si\u00eau nh\u1ecf (d\u00e0i kho\u1ea3ng n\u1eeda mm). \u0110\u1ea7u kia c\u1ee7a aptamer \u0111\u01b0\u1ee3c g\u1eafn v\u1edbi c\u00e1c ph\u00e2n t\u1eed \u0111\u1eb7c bi\u1ec7t t\u1ea1o ra c\u00e1c t\u00edn hi\u1ec7u c\u00f3 th\u1ec3 \u0111o \u0111\u01b0\u1ee3c khi aptamer thay \u0111\u1ed5i h\u00ecnh d\u1ea1ng. C\u00e1c b\u00e1c s\u0129 s\u1ebd bi\u1ebft \u0111\u01b0\u1ee3c l\u01b0\u1ee3ng thu\u1ed1c trong c\u01a1 th\u1ec3 nh\u1edd c\u00e1c t\u00edn hi\u1ec7u \u0111\u00f3.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 10pt;\">C\u00e1c nh\u00e0 nghi\u00ean c\u1ee9u \u0111\u00e3 s\u1eed d\u1ee5ng ba li\u1ec1u l\u01b0\u1ee3ng kh\u00e1c nhau c\u1ee7a thu\u1ed1c kh\u00e1ng sinh tobramycin tr\u00ean chu\u1ed9t. K\u1ebft qu\u1ea3 cho th\u1ea5y, c\u00e1c k\u1ebft qu\u1ea3 \u0111o n\u1ed3ng \u0111\u1ed9 thu\u1ed1c c\u1ee7a mi\u1ebfng d\u00e1n t\u01b0\u01a1ng \u0111\u01b0\u01a1ng v\u1edbi c\u00e1c k\u1ebft qu\u1ea3 t\u1eeb c\u00e1c x\u00e9t nghi\u1ec7m m\u00e1u th\u00f4ng th\u01b0\u1eddng. C\u00f4ng ngh\u1ec7 vi kim c\u1ea3m \u1ee9ng sinh h\u1ecdc n\u00e0y cho ph\u00e9p c\u1ea3i thi\u1ec7n ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb b\u1eb1ng c\u00e1ch t\u1ed1i \u01b0u h\u00f3a li\u1ec1u l\u01b0\u1ee3ng thu\u1ed1c cho t\u1eebng c\u00e1 nh\u00e2n v\u00e0 kh\u00f4ng t\u1ed1n k\u00e9m.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 10pt;\">Vi\u1ec7c ph\u00e1t tri\u1ec3n mi\u1ebfng d\u00e1n c\u1ea3m bi\u1ebfn n\u00e0y cho ph\u00e9p c\u00e1c b\u00e1c s\u0129 qu\u1ea3n l\u00fd li\u1ec1u l\u01b0\u1ee3ng c\u00e1c lo\u1ea1i thu\u1ed1c c\u00f3 kho\u1ea3ng c\u00e1ch h\u1eb9p gi\u1eefa li\u1ec1u \u0111i\u1ec1u tr\u1ecb v\u00e0 li\u1ec1u \u0111\u1ed9c m\u1ed9t c\u00e1ch an to\u00e0n h\u01a1n, \u0111\u1ed3ng th\u1eddi gi\u00fap gi\u1ea3m thi\u1ec3u kh\u1ea3 n\u0103ng c\u00e1c vi khu\u1ea9n nguy hi\u1ec3m kh\u00e1ng thu\u1ed1c kh\u00e1ng sinh.<\/span><\/p>\n<p style=\"text-align: right;\"><span style=\"font-family: arial, helvetica, sans-serif; font-size: 10pt;\"><em>Theo VietQ<\/em><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>C\u00e1c b\u00e1c s\u0129 c\u00f3 th\u1ec3 ki\u1ec3m so\u00e1t \u0111\u01b0\u1ee3c l\u01b0\u1ee3ng thu\u1ed1c h\u1ea5p th\u1ee5 trong c\u01a1 th\u1ec3 nh\u1edd mi\u1ebfng d\u00e1n c\u1ea3m bi\u1ebfn sinh h\u1ecdc, \u0111\u1eb7c bi\u1ec7t l\u00e0 c\u00e1c thu\u1ed1c \u0111i\u1ec1u tr\u1ecb b\u1ec7nh n\u1eb7ng. V\u1edbi nhi\u1ec1u lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb nhi\u1ec5m tr\u00f9ng v\u00e0 ung th\u01b0, gi\u1eefa li\u1ec1u thu\u1ed1c ch\u1eefa b\u1ec7nh v\u00e0 li\u1ec1u g\u00e2y ra t\u00e1c d\u1ee5ng ph\u1ee5 nguy [&hellip;]<\/p>\n","protected":false},"author":10,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[22],"tags":[],"acf":{"linh-vuc":"C\u00e1c l\u0129nh v\u1ef1c kh\u00e1c"},"_links":{"self":[{"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/posts\/71821"}],"collection":[{"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/comments?post=71821"}],"version-history":[{"count":0,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/posts\/71821\/revisions"}],"wp:attachment":[{"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/media?parent=71821"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/categories?post=71821"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tcvn.gov.vn\/wp-json\/wp\/v2\/tags?post=71821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}