{"id":7708,"date":"2021-07-02T14:11:07","date_gmt":"2021-07-02T07:11:07","guid":{"rendered":"https:\/\/vinatom.gov.vn\/?p=7708"},"modified":"2021-07-02T14:11:07","modified_gmt":"2021-07-02T07:11:07","slug":"dieu-tri-dich-ung-thu-dau-co-bang-khang-the-don-dong-gan-dong-vi-phong-xa-cong-nghe-san-xuat-tai-vien-nghien-cuu-hat-nhan","status":"publish","type":"post","link":"https:\/\/vinatom.gov.vn\/dieu-tri-dich-ung-thu-dau-co-bang-khang-the-don-dong-gan-dong-vi-phong-xa-cong-nghe-san-xuat-tai-vien-nghien-cuu-hat-nhan\/","title":{"rendered":"\u0110i\u1ec1u tr\u1ecb \u0111\u00edch ung th\u01b0 \u0111\u1ea7u c\u1ed5 b\u1eb1ng kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng g\u1eafn \u0111\u1ed3ng v\u1ecb ph\u00f3ng x\u1ea1 – c\u00f4ng ngh\u1ec7 s\u1ea3n xu\u1ea5t t\u1ea1i Vi\u1ec7n Nghi\u00ean c\u1ee9u h\u1ea1t nh\u00e2n"},"content":{"rendered":"

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\u0110i\u1ec1u tr\u1ecb b\u1ec7nh b\u1eb1ng kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng l\u00e0 kh\u00e1i ni\u1ec7m c\u00f2n nhi\u1ec1u xa l\u1ea1 \u0111\u1ed1i v\u1edbi ch\u00fang ta v\u00e0 kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng g\u1eafn \u0111\u1ed3ng v\u1ecb ph\u00f3ng x\u1ea1 nghe c\u00f2n xa l\u1ea1 h\u01a1n n\u1eefa. Tuy nhi\u00ean, m\u1edbi \u0111\u00e2y, ng\u00e0y 05\/5\/2021, C\u1ee5c qu\u1ea3n l\u00fd Th\u1ef1c ph\u1ea9m v\u00e0 D\u01b0\u1ee3c ph\u1ea9m Hoa K\u1ef3 (FDA) \u0111\u00e3 ph\u00ea duy\u1ec7t kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng th\u1ee9 100 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng \u0111i\u1ec1u tr\u1ecb l\u00e2m s\u00e0ng. Ngo\u00e0i ra, c\u00f2n c\u00f3 h\u00e0ng tr\u0103m lo\u1ea1i kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng kh\u00e1c \u0111ang trong giai \u0111o\u1ea1n \u0111\u00e1nh gi\u00e1 ti\u1ec1n l\u00e2m s\u00e0ng. B\u00ean c\u1ea1nh \u0111\u00f3, thu\u1ed1c ph\u00f3ng x\u1ea1 kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng c\u0169ng ng\u00e0y c\u00e0ng ph\u00e1t tri\u1ec3n nh\u1edd c\u00f3 nhi\u1ec1u \u01b0u \u0111i\u1ec3m v\u00e0 hi\u1ec7u qu\u1ea3 mang l\u1ea1i.<\/p>\n

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Trong nhi\u1ec1u n\u0103m qua, t\u1ea1i Vi\u1ec7n Nghi\u00ean c\u1ee9u h\u1ea1t nh\u00e2n, ngo\u00e0i nh\u1eefng thu\u1ed1c ph\u00f3ng x\u1ea1 th\u00f4ng th\u01b0\u1eddng \u0111\u00e3 cung c\u1ea5p v\u00e0 s\u1eed d\u1ee5ng th\u01b0\u1eddng xuy\u00ean tr\u00ean l\u00e2m s\u00e0ng nh\u01b0 ^{131<\/sup>I, ^{32<\/sup>P, ^{99m<\/sup>Tc, m\u1ed9t s\u1ed1 thu\u1ed1c ph\u00f3ng x\u1ea1 kh\u00e1ng th\u1ec3 th\u1ebf h\u1ec7 m\u1edbi c\u0169ng \u0111\u00e3 \u0111\u01b0\u1ee3c nghi\u00ean c\u1ee9u v\u00e0 ph\u00e1t tri\u1ec3n. V\u00ed d\u1ee5 nh\u01b0 ^{131<\/sup>I-rituximab \u0111i\u1ec1u tr\u1ecb ung th\u01b0 lympho b\u00e0o B kh\u00f4ng Hodgkin, ^{131<\/sup>I-kh\u00e1ng th\u1ec3 kh\u00e1ng nh\u00e2n \u0111i\u1ec1u tr\u1ecb c\u00e1c ung th\u01b0 d\u1ea1ng r\u1eafn (solid tumor) v\u00e0 ^{131<\/sup>I-hR3 v\u00e0 ^{90<\/sup>Y-hR3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o v\u1ea3y \u0111\u1ea7u c\u1ed5.<\/p>\n}}}}}}}

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Ung th\u01b0 \u0111\u1ea7u c\u1ed5 l\u00e0 nh\u1eefng ung th\u01b0\u00a0ph\u00e1t tri\u1ec3n t\u1eeb nh\u1eefng v\u1ecb tr\u00ed kh\u00e1c nhau \u1edf v\u00f9ng \u0111\u1ea7u v\u00e0 c\u1ed5, bao g\u1ed3m ung th\u01b0 khoang mi\u1ec7ng, v\u00f2m h\u1ecdng, c\u00e1c xoang m\u1eb7t, s\u00e0n mi\u1ec7ng, h\u1ea7u, h\u1ea1 h\u1ecdng, h\u1ed1c m\u0169i, thanh qu\u1ea3n, tuy\u1ebfn n\u01b0\u1edbc b\u1ecdt, l\u01b0\u1ee1i, tuy\u1ebfn gi\u00e1p. Nh\u01b0 t\u00ean g\u1ecdi, v\u1ecb tr\u00ed c\u1ee7a ung th\u01b0 kh\u00f3 x\u00e1c \u0111\u1ecbnh v\u00e0 theo d\u00f5i b\u1eb1ng c\u00e1c ph\u01b0\u01a1ng ph\u00e1p th\u00f4ng th\u01b0\u1eddng, \u0111i\u1ec1u tr\u1ecb \u0111\u00edch b\u1eb1ng ^{131<\/sup>I-hR3 v\u00e0 ^{90<\/sup>Y-hR3 s\u1ebd mang l\u1ea1i nhi\u1ec1u l\u1ee3i \u00edch cho b\u1ec7nh nh\u00e2n v\u00e0 c\u00f3 th\u1ec3 \u0111\u00e1nh gi\u00e1 \u0111\u01b0\u1ee3c b\u1eb1ng c\u00e1c k\u1ef9 thu\u1eadt y h\u1ecdc h\u1ea1t nh\u00e2n hi\u1ec7n \u0111\u1ea1i, trong \u0111\u00f3 c\u00f3 PET-CT. Theo Globcan n\u0103m 2020, trong s\u1ed1 19,3 tri\u1ec7u ca ung th\u01b0 m\u1eafc m\u1edbi th\u00ec c\u00f3 t\u1edbi 4,3 tri\u1ec7u ca ung th\u01b0 \u0111\u1ea7u c\u1ed5 (chi\u1ebfm 22,2 %) v\u00e0 t\u1ef7 l\u1ec7 ch\u1ebft l\u00ean t\u1edbi h\u01a1n 2,1 tri\u1ec7u ca.<\/p>\n}}

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$\"\"$ Kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng hR3 \u0111\u00e1nh d\u1ea5u v\u1edbi \u0111\u1ed3ng v\u1ecb ph\u00f3ng x\u1ea1 ^{131<\/sup>I<\/em>\/<\/em>^{90<\/sup><\/em>Y v\u00e0 \u1ee9ng d\u1ee5ng c\u1ee7a\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 \u00a0^{131<\/sup>I-<\/em>hR3<\/em> v\u00e0 ^{90<\/sup>Y<\/em>–<\/em>hR3 <\/em>\u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u1ea7u c\u1ed5<\/em><\/p>\n}}}}

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\u0110\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u1ea7u c\u1ed5, ngo\u00e0i c\u00e1c ph\u01b0\u01a1ng ph\u00e1p nh\u01b0 ph\u1eabu thu\u1eadt, h\u00f3a tr\u1ecb v\u00e0 x\u1ea1 tr\u1ecb c\u00f2n c\u00f3 c\u00e1c ph\u01b0\u01a1ng ph\u00e1p m\u1edbi nh\u01b0 k\u1ef9 thu\u1eadt \u0111i\u1ec1u tr\u1ecb b\u1eb1ng s\u00f3ng cao t\u1ea7n, \u0111i\u1ec1u tr\u1ecb b\u1eb1ng gen, \u0111i\u1ec1u tr\u1ecb b\u1eb1ng b\u1ee9c x\u1ea1 proton, \u0111i\u1ec1u tr\u1ecb b\u1eb1ng tia laser v\u00e0 \u0111i\u1ec1u tr\u1ecb mi\u1ec5n d\u1ecbch ph\u00f3ng x\u1ea1.<\/p>\n

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Thu\u1ed1c ph\u00f3ng x\u1ea1 ^{131<\/sup>I-hR3 v\u00e0 ^{90<\/sup>Y-hR3, l\u00e0 nh\u1eefng d\u01b0\u1ee3c ch\u1ea5t ph\u00f3ng x\u1ea1 m\u1edbi, l\u1ea7n \u0111\u1ea7u ti\u00ean nghi\u00ean c\u1ee9u s\u1ea3n xu\u1ea5t t\u1ea1i Vi\u1ec7t Nam, c\u00f3 t\u00ednh \u0111\u1eb7c hi\u1ec7u cao v\u1edbi c\u00e1c ung th\u01b0 bi\u1ec3u m\u00f4 t\u1ebf b\u00e0o v\u1ea3y v\u1edbi s\u1ef1 bi\u1ec3u hi\u1ec7n cao c\u00e1c y\u1ebfu t\u1ed1 t\u0103ng tr\u01b0\u1edfng bi\u1ec3u b\u00ec EGFR (epidermal growth factor receptor). Thu\u1ed1c bao g\u1ed3m kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng hR3 v\u00e0 \u0111\u1ed3ng v\u1ecb ph\u00f3ng x\u1ea1 ^{131<\/sup>I\/^{90<\/sup>Y. hR3 l\u00e0 kh\u00e1ng th\u1ec3 thu\u1ed9c lo\u1ea1i IgG1, b\u1ea3n ch\u1ea5t l\u00e0 kh\u00e1ng th\u1ec3 \u0111\u01b0\u1ee3c l\u00e0m t\u01b0\u01a1ng th\u00edch v\u1edbi ng\u01b0\u1eddi. S\u1ea3n ph\u1ea9m c\u00f3 \u0111\u1ed9 tinh khi\u1ebft h\u00f3a ph\u00f3ng x\u1ea1 \u0111\u1ea1t h\u01a1n 98 % v\u00e0 \u0111\u1ed9 tinh khi\u1ebft h\u1ea1t nh\u00e2n \u0111\u1ea1t h\u01a1n 99,99 %, \u0111\u1ea1t c\u00e1c ch\u1ec9 ti\u00eau ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a thu\u1ed1c ph\u00f3ng x\u1ea1 d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb nh\u01b0 l\u00e0 ho\u1ea1t t\u00ednh \u0111\u1eb7c hi\u1ec7u 187-191 MBq\/mg, ho\u1ea1t t\u00ednh mi\u1ec5n d\u1ecbch l\u1edbn h\u01a1n 80 % tr\u00ean t\u1ebf b\u00e0o ung th\u01b0 c\u00f3 bi\u1ec3u hi\u1ec7n EGFR cao, v\u00f4 khu\u1ea9n, kh\u00f4ng ch\u1ee9a n\u1ed9i \u0111\u1ed9c t\u1ed1 vi khu\u1ea9n. Thu\u1ed1c \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u00e1nh gi\u00e1 ch\u1ee5p x\u1ea1 h\u00ecnh v\u00e0 \u0111i\u1ec1u tr\u1ecb tr\u00ean chu\u1ed9t nude mang kh\u1ed1i ung th\u01b0 ng\u01b0\u1eddi v\u1edbi hi\u1ec7u qu\u1ea3 cao, v\u00ed d\u1ee5 nh\u01b0 \u0111i\u1ec1u tr\u1ecb \u0111\u01a1n li\u1ec1u 5,55 MBq m\u1ed7i lo\u1ea1i, t\u1ef7 l\u1ec7 \u1ee9c ch\u1ebf kh\u1ed1i u c\u1ee7a ^{131<\/sup>I-hR3 l\u00e0 16,1 % so v\u1edbi nh\u00f3m ti\u00eam kh\u00e1ng th\u1ec3 hR3 v\u00e0 46,5 % so v\u1edbi nh\u00f3m ti\u00eam n\u01b0\u1edbc mu\u1ed1i sinh l\u00fd (p<0,01), t\u1ef7 l\u1ec7 \u1ee9c ch\u1ebf kh\u1ed1i u c\u1ee7a ^{90<\/sup>Y-hR3 l\u00e0 34,3 % so v\u1edbi nh\u00f3m ti\u00eam kh\u00e1ng th\u1ec3 hR3 v\u00e0 58,1 % so v\u1edbi nh\u00f3m ti\u00eam n\u01b0\u1edbc mu\u1ed1i sinh l\u00fd (p<0,001). Ph\u00e2n t\u00edch Kaplan-Meier cho th\u1ea5y t\u1ef7 l\u1ec7 s\u1ed1ng c\u00f2n nh\u00f3m \u0111i\u1ec1u tr\u1ecb h\u01a1n 1,8 l\u1ea7n nh\u00f3m kh\u00f4ng \u0111i\u1ec1u tr\u1ecb.<\/p>\n}}}}}}

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V\u1ec1 c\u01a1 ch\u1ebf t\u00e1c d\u1ee5ng, ^{131<\/sup>I-hR3 v\u00e0 ^{90<\/sup>Y-hR3 b\u00ean c\u1ea1nh ch\u1ee9c n\u0103ng ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0 theo c\u00e1c c\u01a1 ch\u1ebf sinh h\u1ecdc nh\u01b0 ch\u1ed1ng t\u0103ng sinh m\u1ea1ch, k\u00ecm h\u00e3m t\u0103ng sinh t\u1ebf b\u00e0o, c\u1ea3m \u1ee9ng t\u1ebf b\u00e0o ch\u1ebft theo ch\u01b0\u01a1ng tr\u00ecnh, gi\u1ea3m chuy\u1ec3n h\u00f3a v\u00e0 ch\u1ebft t\u1ebf b\u00e0o b\u1ec7nh c\u00f2n ti\u00eau di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0 theo c\u01a1 ch\u1ebf b\u1ee9c x\u1ea1 ion h\u00f3a nh\u1edd n\u0103ng l\u01b0\u1ee3ng b\u1ee9c x\u1ea1 tia beta c\u1ee7a ^{131<\/sup>I\/^{90<\/sup>Y (606 KeV\/2.280 KeV).<\/p>\n}}}}

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V\u1ec1 c\u00f4ng ngh\u1ec7 s\u1ea3n xu\u1ea5t, \u0111\u1ec3 \u0111i\u1ec1u ch\u1ebf ^{131<\/sup>I-hR3, d\u00f9ng ph\u01b0\u01a1ng ph\u00e1p chloramin T, ^{131<\/sup>I b\u1ecb oxy h\u00f3a trong s\u1ef1 c\u00f3 m\u1eb7t c\u1ee7a kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng. ^{131<\/sup>I ph\u00f3ng x\u1ea1 g\u1eafn v\u00e0o tyrosine tr\u00ean ph\u00e2n t\u1eed kh\u00e1ng th\u1ec3 v\u1edbi hi\u1ec7u su\u1ea5t cao, h\u1ee3p ch\u1ea5t \u0111\u00e1nh d\u1ea5u ^{131<\/sup>I-hR3 \u0111\u01b0\u1ee3c tinh s\u1ea1ch b\u1eb1ng k\u1ef9 thu\u1eadt l\u1ecdc gel sephadex. L\u01b0\u1ee3ng ch\u1ea5t oxy h\u00f3a v\u00e0 ch\u1ea5t kh\u1eed s\u1eed d\u1ee5ng v\u1edbi n\u1ed3ng \u0111\u1ed9 t\u1ed1i thi\u1ec3u nh\u1eb1m h\u1ea1n ch\u1ebf s\u1ef1 m\u1ea5t ho\u1ea1t t\u00ednh c\u1ee7a kh\u00e1ng th\u1ec3. Th\u1eddi gian ph\u1ea3n \u1ee9ng x\u1ea3y ra nhanh. S\u1ea3n ph\u1ea9m thu \u0111\u01b0\u1ee3c c\u00f3 hi\u1ec7u su\u1ea5t cao v\u00e0 ho\u1ea1t t\u00ednh ri\u00eang cao, ph\u00f9 h\u1ee3p v\u1edbi c\u00e1c c\u00f4ng b\u1ed1 qu\u1ed1c t\u1ebf. \u0110\u1ec3 \u0111i\u1ec1u ch\u1ebf ^{90<\/sup>Y-hR3, ph\u1ea3i tr\u1ea3i qua nhi\u1ec1u c\u00f4ng \u0111o\u1ea1n. \u0110\u1ea7u ti\u00ean, kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng hR3 \u0111\u01b0\u1ee3c g\u1eafn v\u1edbi p-SCN-benzyl-DOTA b\u1eb1ng k\u1ef9 thu\u1eadt t\u1ea1o ph\u1ee9c gi\u1eefa m\u1ed9t ch\u1ea5t l\u00e0 ph\u00e2n t\u1eed sinh h\u1ecdc v\u1edbi m\u1ed9t ch\u1ea5t l\u00e0 ch\u1ea5t t\u1ea1o ph\u1ee9c c\u00e0ng cua t\u1ea1o n\u00ean DOTA-hR3 v\u00e0 tinh s\u1ea1ch b\u1eb1ng c\u00e1c k\u1ef9 thu\u1eadt l\u1ecdc gel, th\u1ea9m t\u00edch, c\u0169ng nh\u01b0 ki\u1ec3m tra ch\u1ea5t l\u01b0\u1ee3ng ph\u1ee9c h\u1ee3p. Sau \u0111\u00f3, \u0111\u00e1nh d\u1ea5u v\u1edbi \u0111\u1ed3ng v\u1ecb ph\u00f3ng x\u1ea1 ^{90<\/sup>Y b\u1eb1ng c\u00e1ch \u1ee7 p-SNC-benzyl-DOTA-hR3 v\u1edbi ch\u1ea5t ph\u00f3ng x\u1ea1 trong \u0111\u1ec7m acetate, nhi\u1ec7t \u0111\u1ed9 42^{0<\/sup>C, th\u1eddi gian ph\u1ea3n \u1ee9ng l\u00e0 60 ph\u00fat. Ph\u1ee9c mi\u1ec5n d\u1ecbch ph\u00f3ng x\u1ea1 ^{90<\/sup>Y-benzyl-DOTA-hR3 t\u1ea1o th\u00e0nh \u0111\u01b0\u1ee3c tinh s\u1ea1ch b\u1eb1ng k\u1ef9 thu\u1eadt l\u1ecdc gel sephadex. S\u1ea3n ph\u1ea9m \u0111\u01b0\u1ee3c ki\u1ec3m tra ch\u1ea5t l\u01b0\u1ee3ng v\u00e0 ch\u1ee9ng minh b\u1ec1n invitro<\/em> v\u00e0 invivo<\/em> h\u01a1n l\u00e0 s\u1eed d\u1ee5ng c\u00e1c d\u1eabn xu\u1ea5t kh\u00e1c nh\u01b0 DTPA, p<\/em>-NH2-Bn-DOTA ho\u1eb7c DOTA-tris. K\u1ebft qu\u1ea3 v\u00e0 ch\u1ea5t l\u01b0\u1ee3ng s\u1ea3n ph\u1ea9m \u0111\u1ea1t c\u00e1c ti\u00eau ch\u00ed nh\u01b0 D\u01b0\u1ee3c \u0111i\u1ec3n v\u00e0 ph\u00f9 h\u1ee3p v\u1edbi c\u00e1c nghi\u00ean c\u1ee9u \u0111\u00e3 c\u00f4ng b\u1ed1 tr\u00ean th\u1ebf gi\u1edbi.<\/p>\n}}}}}}}}

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\u0110\u00e2y l\u00e0 l\u1ea7n \u0111\u1ea7u ti\u00ean k\u1ef9 thu\u1eadt nghi\u00ean c\u1ee9u \u0111i\u1ec1u ch\u1ebf thu\u1ed1c ph\u00f3ng x\u1ea1 ^{131<\/sup>I-hR3 v\u00e0 ^{90<\/sup>Y-hR3 d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb \u0111\u00edch ung th\u01b0 \u0111\u1ea7u c\u1ed5 \u0111\u01b0\u1ee3c \u0111\u01b0a v\u00e0o nghi\u00ean c\u1ee9u \u0111i\u1ec1u ch\u1ebf t\u1ea1i Vi\u1ec7t Nam. Ch\u00fang ta l\u00e0m ch\u1ee7 \u0111\u01b0\u1ee3c c\u00f4ng ngh\u1ec7. Vi\u1ec7c \u0111i\u1ec1u ch\u1ebf thu\u1ed1c ph\u00f3ng x\u1ea1 trong n\u01b0\u1edbc c\u00f3 \u00fd ngh\u0129a khoa h\u1ecdc v\u00e0 th\u1ef1c ti\u1ec5n, b\u1edfi nhu c\u1ea7u s\u1eed d\u1ee5ng l\u00e0 r\u1ea5t l\u1edbn, tr\u01b0\u1edbc m\u1eaft t\u1ea1o ra s\u1ea3n ph\u1ea9m thu\u1ed1c ph\u00f3ng x\u1ea1 nh\u1eafm \u0111\u00edch d\u00f9ng trong \u0111i\u1ec1u tr\u1ecb ung th\u01b0 \u0111\u1ea7u c\u1ed5 b\u1eb1ng k\u1ef9 thu\u1eadt mi\u1ec5n d\u1ecbch ph\u00f3ng x\u1ea1, m\u1edf ra h\u01b0\u1edbng ch\u1ea9n \u0111o\u00e1n v\u00e0 \u0111i\u1ec1u tr\u1ecb m\u1edbi. B\u1ec7nh nh\u00e2n ung th\u01b0 \u0111\u01b0\u1ee3c s\u1eed d\u1ee5ng v\u00e0 \u0111\u01b0\u1ee3c \u0111\u00e1p \u1ee9ng k\u1ecbp th\u1eddi theo nhu c\u1ea7u. Ngu\u1ed3n nguy\u00ean v\u1eadt li\u1ec7u c\u0169ng c\u00f3 th\u1ec3 ch\u1ee7 \u0111\u1ed9ng \u0111\u01b0\u1ee3c.<\/p>\n}}

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B\u00ean c\u1ea1nh \u0111\u00f3, s\u1ea3n xu\u1ea5t trong n\u01b0\u1edbc gi\u00e1 th\u00e0nh s\u1ebd r\u1ebb h\u01a1n nhi\u1ec1u so v\u1edbi nh\u1eadp ngo\u1ea1i. Gi\u1ea3m chi ph\u00ed \u0111\u00e1ng k\u1ec3 cho b\u1ec7nh nh\u00e2n n\u1ebfu nh\u01b0 \u0111i n\u01b0\u1edbc ngo\u00e0i \u0111i\u1ec1u tr\u1ecb. Gi\u00e1 th\u00e0nh b\u00e1n trong n\u01b0\u1edbc l\u00e0 20-40 tri\u1ec7u \u0111\u1ed3ng\/li\u1ec1u \u0111i\u1ec1u tr\u1ecb, trong khi \u0111\u00f3 nh\u1eadp ngo\u1ea1i l\u00e0 200-400 tri\u1ec7u \u0111\u1ed3ng\/li\u1ec1u \u0111i\u1ec1u tr\u1ecb. Tri\u1ec3n khai s\u1ea3n ph\u1ea9m ti\u1ebft ki\u1ec7m cho b\u1ec7nh nh\u00e2n, ti\u1ebft ki\u1ec7m cho x\u00e3 h\u1ed9i. Ngo\u00e0i ra, n\u1ebfu \u0111\u01b0\u1ee3c tri\u1ec3n khai \u1ee9ng d\u1ee5ng tr\u00ean di\u1ec7n r\u1ed9ng, s\u1ebd n\u00e2ng cao \u0111\u00e1ng k\u1ec3 n\u0103ng l\u1ef1c s\u1ea3n xu\u1ea5t thu\u1ed1c trong n\u01b0\u1edbc v\u00e0 \u0111\u00e0o t\u1ea1o \u0111\u01b0\u1ee3c \u0111\u1ed9i ng\u0169 chuy\u00ean m\u00f4n cho ng\u00e0nh g\u00f3p ph\u1ea7n v\u00e0o c\u00f4ng cu\u1ed9c x\u00e2y d\u1ef1ng v\u00e0 ph\u00e1t tri\u1ec3n \u0111\u1ea5t n\u01b0\u1edbc.<\/p>\n

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Nh\u00ecn l\u1ea1i ch\u1eb7ng \u0111\u01b0\u1eddng nghi\u00ean c\u1ee9u, h\u1ecdc t\u1eadp v\u00e0 lao \u0111\u1ed9ng s\u00e1ng t\u1ea1o, m\u1edbi ng\u00e0y n\u00e0o \u0111\u00e2y, t\u1eadp th\u1ec3 c\u00e1n b\u1ed9 l\u00e0m vi\u1ec7c trong l\u0129nh v\u1ef1c nghi\u00ean c\u1ee9u \u0111i\u1ec1u ch\u1ebf thu\u1ed1c ph\u00f3ng x\u1ea1 \u0111\u00e3 ph\u1ea5n \u0111\u1ea5u kh\u00f4ng ng\u1eebng \u0111\u1ec3 ho\u00e0n thi\u1ec7n, \u0111\u1ed5i m\u1edbi c\u00f4ng ngh\u1ec7, cu\u1ed1i c\u00f9ng l\u00e0, s\u1ea3n ph\u1ea9m m\u1edbi kh\u00e1ng th\u1ec3 \u0111\u01a1n d\u00f2ng g\u1eafn \u0111\u1ed3ng v\u1ecb ph\u00f3ng x\u1ea1 ^{131<\/sup>I-hR3 v\u00e0 ^{90<\/sup>Y-hR3 c\u0169ng \u0111\u01b0\u1ee3c ra \u0111\u1eddi v\u1edbi nhi\u1ec1u tri\u1ec3n v\u1ecdng s\u1eed d\u1ee5ng tr\u00ean l\u00e2m s\u00e0ng. C\u00f3 th\u1ec3 th\u1ea5y r\u1eb1ng, ngo\u00e0i \u0111i\u1ec1u tr\u1ecb \u0111\u00edch c\u00e1c ung th\u01b0 \u0111\u1eb7c hi\u1ec7u, ti\u1ec1m n\u0103ng m\u1edf r\u1ed9ng \u1ee9ng d\u1ee5ng tr\u00ean nh\u1eefng b\u1ec7nh \u0111\u1eb7c bi\u1ec7t kh\u00e1c l\u00e0 r\u1ea5t l\u1edbn.<\/p>\n}}

\u00a0<\/em><\/p>\n

Nguy\u1ec5n Th\u1ecb Thu, Vi\u1ec7n Nghi\u00ean c\u1ee9u h\u1ea1t nh\u00e2n <\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"

\u0110\u1ec3 tri\u1ec3n khai \u1ee9ng d\u1ee5ng nh\u1eefng k\u1ebft qu\u1ea3 \u0111\u1ea1t \u0111\u01b0\u1ee3c trong nghi\u00ean c\u1ee9u khoa h\u1ecdc v\u00e0o th\u1ef1c ti\u1ec5n, g\u00f3p ph\u1ea7n th\u1ef1c hi\u1ec7n \u201cChi\u1ebfn l\u01b0\u1ee3c \u1ee9ng d\u1ee5ng n\u0103ng l\u01b0\u1ee3ng nguy\u00ean t\u1eed v\u00ec m\u1ee5c \u0111\u00edch h\u00f2a b\u00ecnh\u201d, Vi\u1ec7n Nghi\u00ean c\u1ee9u h\u1ea1t nh\u00e2n \u0111\u00e3 ph\u00e1t tri\u1ec3n c\u00f4ng ngh\u1ec7 \u0111i\u1ec1u ch\u1ebf c\u00e1c s\u1ea3n ph\u1ea9m thu\u1ed1c ph\u00f3ng x\u1ea1 \u0111i\u1ec1u tr\u1ecb […]<\/p>\n","protected":false},"author":1,"featured_media":7709,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[26],"tags":[],"class_list":["post-7708","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-tin-tong-hop"],"_links":{"self":[{"href":"https:\/\/vinatom.gov.vn\/wp-json\/wp\/v2\/posts\/7708","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/vinatom.gov.vn\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/vinatom.gov.vn\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/vinatom.gov.vn\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/vinatom.gov.vn\/wp-json\/wp\/v2\/comments?post=7708"}],"version-history":[{"count":0,"href":"https:\/\/vinatom.gov.vn\/wp-json\/wp\/v2\/posts\/7708\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/vinatom.gov.vn\/wp-json\/"}],"wp:attachment":[{"href":"https:\/\/vinatom.gov.vn\/wp-json\/wp\/v2\/media?parent=7708"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/vinatom.gov.vn\/wp-json\/wp\/v2\/categories?post=7708"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/vinatom.gov.vn\/wp-json\/wp\/v2\/tags?post=7708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}